Activation of the renin-angiotensin system within podocytes in diabetes

scientific article published on 14 March 2007

Activation of the renin-angiotensin system within podocytes in diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.KI.5002195
P8608Fatcat IDrelease_c5xdosvdajg2nbbci47zzh5skq
P698PubMed publication ID17361112
P5875ResearchGate publication ID6446347

P50authorJong Eun LeeQ38323530
Dong-Ryeol RyuQ43973018
P2093author name stringKim HJ
Kim JJ
Han SH
Kim JS
Han DS
Kang SW
Choi HY
Jung DS
Kwak SJ
Li JJ
Yoo TH
P2860cites workProteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibitionQ28215181
Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruliQ28565628
High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cellsQ28568580
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyQ29615215
AT(1) and AT(2) receptors in the kidney: role in disease and treatment.Q30306077
ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse developmentQ30434317
Update on the role of the AT2 receptorQ30435327
Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic ratsQ31063566
Activation of a local tissue angiotensin system in podocytes by mechanical strainQ33195945
Role of angiotensin II in diabetic nephropathy.Q34039750
Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucoseQ34573082
Podocyte biology and the emerging understanding of podocyte diseasesQ35198433
Podocyte loss and progressive glomerular injury in type II diabetesQ37362675
Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective interventionQ38623177
A quantitative immunofluorescence study of glomerular cell adhesion proteins in proteinuric statesQ39458149
Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II.Q39645421
The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathyQ40205911
Characterization of angiotensin II-receptor subtypes in podocytesQ40611479
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cellsQ41065781
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.Q41084039
The role of angiotensin II in diabetic nephropathy: emphasis on nonhemodynamic mechanismsQ41323510
Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose mediumQ41581730
Irbesartan normalises the deficiency in glomerular nephrin expression in a model of diabetes and hypertensionQ43709059
Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockadeQ43709062
Podocyte number in normotensive type 1 diabetic patients with albuminuriaQ44155574
Hypoxia and high glucose upregulate AT1 receptor expression and potentiate ANG II-induced proliferation in VSM cellsQ44217757
Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucoseQ44378900
Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathyQ44378923
ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathyQ44475434
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular diseaseQ44486184
Renoprotective effects of adding angiotensin II receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trialQ44526964
Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes.Q44669218
Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy.Q45000528
P-Cadherin is decreased in diabetic glomeruli and in glucose-stimulated podocytes in vivo and in vitro studies.Q45221667
A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruliQ45258260
Functional expression of the renin-angiotensin system in human podocytesQ46724544
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase CQ69059319
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study GroupQ70513402
Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradationQ73060915
Glomerular cell number in normal subjects and in type 1 diabetic patientsQ73942888
Urinary excretion of podocytes in patients with diabetic nephropathyQ74291207
Angiotensin II modulates cellular functions of podocytesQ77295873
The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biologyQ78461702
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1019-1027
P577publication date2007-03-14
P1433published inKidney InternationalQ6404823
P1476titleActivation of the renin-angiotensin system within podocytes in diabetes
P478volume71

Reverse relations

cites work (P2860)
Q371902441,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway
Q34455455Activation of NFAT signaling in podocytes causes glomerulosclerosis
Q46794009Activation of a local renin angiotensin system in podocytes by glucose
Q46250380Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice
Q83835489Activation of skin renin-angiotensin system in diabetic rats
Q85195034Adenosine A(2B) receptor-mediated VEGF induction promotes diabetic glomerulopathy
Q50475761Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytes.
Q33999815Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
Q37277601Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy
Q46356625Angiotensin II regulates collagen metabolism through modulating tissue inhibitor of metalloproteinase-1 in diabetic skin tissues
Q53254924Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies.
Q36374983Changes of urinary angiotensinogen concentration and its association with urinary proteins in diabetic rats
Q36924964Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase
Q43150818Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
Q46543744Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice
Q34283151Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways
Q90632374Glucose and Blood Pressure-Dependent Pathways-The Progression of Diabetic Kidney Disease
Q42873491Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters
Q35850260Intracardiac intracellular angiotensin system in diabetes
Q53435442Local kallikrein-kinin system is involved in podocyte apoptosis under diabetic conditions.
Q37337349Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist
Q41813557Mechanism of VEGF expression by high glucose in proximal tubule epithelial cells
Q42434881Mesangial cells are responsible for orchestrating the renal podocytes injury in the context of malignant hypertension
Q48659334NMDA receptors participate in the progression of diabetic kidney disease by decreasing Cdc42-GTP activation in podocytes
Q46346105Na+,K+-ATPase is modulated by angiotensin II in diabetic rat kidney--another reason for diabetic nephropathy?
Q37702782New insights into the renoprotective actions of the renin inhibitor aliskiren in experimental renal disease
Q38458152Podocyte directed therapy of nephrotic syndrome-can we bring the inside out?
Q37881701Podocyte dysfunction in aging--related glomerulosclerosis
Q42258796Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice
Q45713726Podocytes of AT2 receptor knockout mice are protected from angiotensin II-mediated RAGE induction
Q37629199ROCK/NF-κB axis-dependent augmentation of angiotensinogen by angiotensin II in primary-cultured preglomerular vascular smooth muscle cells
Q48131156Recent Insights into Pharmacologic Cardiovascular Risk Reduction in Type 2 Diabetes Mellitus
Q57825276Recent Progress in the Pathogenesis of Nephrotic Proteinuria
Q46301431Regression of glomerular injury by losartan in experimental diabetic nephropathy.
Q34203622Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria: effect of angiotensin II blockade
Q52651166Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.
Q38262105Renin-angiotensin system within the diabetic podocyte
Q92536780Role of Podocyte Injury in Glomerulosclerosis
Q35159588Role of the USF1 transcription factor in diabetic kidney disease
Q36175799Role of upstream stimulatory factor 2 in diabetic nephropathy
Q60484091Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy
Q36936570Strict angiotensin blockade prevents the augmentation of intrarenal angiotensin II and podocyte abnormalities in type 2 diabetic rats with microalbuminuria.
Q37344225The importance of the intrarenal renin-angiotensin system
Q38010459The intracrine renin-angiotensin system
Q48649007The locally activated renin-angiotensin system is involved in albumin permeability in glomerular endothelial cells under high glucose conditions.
Q83179650The renin inhibitor aliskiren attenuates high-glucose induced extracellular matrix synthesis and prevents apoptosis in cultured podocytes
Q37838893The role of metabolic and haemodynamic factors in podocyte injury in diabetes
Q53669187Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes.
Q39676702Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients
Q34416954Urinary angiotensinogen and urinary sodium are associated with blood pressure in normoalbuminuric children with diabetes
Q36236725Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes
Q37319731Vitamin D and diabetic nephropathy
Q36426113Vitamin D receptor signaling in podocytes protects against diabetic nephropathy
Q37230136Vitamin D receptor signaling in renal and cardiovascular protection

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