Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord

scientific article published in April 2007

Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord is …
instance of (P31):
scholarly articleQ13442814
MDMAQ69488

External links are
P356DOI10.1111/J.1365-2990.2006.00790.X
P698PubMed publication ID17359360

P50authorMiklós PalkovitsQ1228428
György BagdyQ41173404
Gabor G. KovacsQ41878022
P2093author name stringBenedek A
Adori C
Andó RD
Kirilly E
P2860cites workQuantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASBQ24678394
Ecstasy: are animal data consistent between species and can they translate to humans?Q31033315
(+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animalsQ33950568
Axonal damage: a key predictor of outcome in human CNS diseasesQ34174912
The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").Q34215236
Anatomy of the serotonergic systemQ34270063
Non-linear pharmacokinetics of MDMA ('ecstasy') in humansQ34507084
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrainQ35089051
Long-term impairment of anterograde axonal transport along fiber projections originating in the rostral raphe nuclei after treatment with fenfluramine or methylenedioxymethamphetamineQ43544200
Acute methylenedioxymethamphetamine administration: effects on local cerebral blood flow and glucose utilisation in the Dark Agouti rat.Q44777848
Effects of a single dose of 3,4-methylenedioxymethamphetamine on circadian patterns, motor activity and sleep in drug-naive rats and rats previously exposed to MDMA.Q44843771
Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapineQ44948786
Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampusQ44974818
3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic proteinQ44987921
(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membraneQ46529137
Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti ratsQ46629531
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamineQ48180215
Immunohistochemistry of tryptophan hydroxylase in the rat brainQ48196544
Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryoQ48273482
The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').Q48374881
Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat.Q48481465
Damage of serotonergic axons and immunolocalization of Hsp27, Hsp72, and Hsp90 molecular chaperones after a single dose of MDMA administration in Dark Agouti rat: temporal, spatial, and cellular patternsQ48536718
P433issue2
P304page(s)193-203
P577publication date2007-04-01
P1433published inNeuropathology and Applied NeurobiologyQ7002494
P1476titleSingle dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord
P478volume33

Reverse relations

cites work (P2860)
Q435439853,4-methylenedioxymethamphetamine induces gene expression changes in rats related to serotonergic and dopaminergic systems, but not to neurotoxicity
Q41669953Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake.
Q46763655Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days
Q47927565Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study
Q35078880Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats
Q58803214Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats
Q37629259Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications
Q48878720Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain.
Q55043421Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’): Neurodegeneration versus Neuromodulation.
Q34976260Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview.
Q59619127Recovery and aging of serotonergic fibers after single and intermittent MDMA treatment in dark agouti rat
Q37925507The Nature of 3, 4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonergic Dysfunction: Evidence for and Against the Neurodegeneration Hypothesis
Q59619133Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat
Q28550342Verbal Memory Impairment in Polydrug Ecstasy Users: A Clinical Perspective

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