Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis.

scientific article published on 13 January 2018

Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10456-018-9594-9
P932PMC publication ID5878206
P698PubMed publication ID29332242

P50authorNeil S LagaliQ46067676
Lasse D JensenQ50532645
Pierfrancesco MirabelliQ55834734
Anthony MukwayaQ58403794
Anton LennikovQ60327571
Muthukumar ThangaveluQ87506577
Mieszko LachotaQ87792754
Mira SchaupperQ89867185
Zaheer AliQ89867187
P2093author name stringZaheer Ali
Mira Schaupper
Anton Lennikov
Muthukumar Thangavelu
Mieszko Lachota
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A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptorsQ40488484
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxideQ40910373
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient miceQ40956523
Ikk2 regulates cytokinesis during vertebrate developmentQ41387328
Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea.Q41423380
Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.Q42400395
Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.Q42500751
NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expressionQ44249433
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Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injuryQ44934421
Effect of double-stranded RNA on the expression of epithelial neutrophil activating peptide-78/CXCL-5 in human endothelial cellsQ45239892
Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammationQ46320157
Ten years of anti-vascular endothelial growth factor therapyQ46407140
A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in miceQ46925948
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IκB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.Q51055452
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Use of the mouse aortic ring assay to study angiogenesisQ58313759
CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression ProfileQ61865899
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2Q64378091
Neutrophils promote inflammatory angiogenesis via release of preformed VEGF in an in vivo corneal modelQ82251889
Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cellsQ83516314
Cellular level characterization of capillary regression in inflammatory angiogenesis using an in vivo corneal modelQ84535269
An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cellsQ84997618
Early effects of dexamethasone and anti-VEGF therapy in an inflammatory corneal neovascularization modelQ88089018
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectNF-κBQ411114
P304page(s)267-285
P577publication date2018-01-13
P1433published inAngiogenesisQ15753544
P1476titleSelective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis
P478volume21

Reverse relations

cites work (P2860)
Q89124983Current and emerging therapies for corneal neovascularization
Q96348268Inhibition of miR-450b-5p ameliorates hepatic ischemia/reperfusion injury via targeting CRYAB
Q92308065Mesenchymal Stem Cell-Derived Extracellular Vesicles for Corneal Wound Repair
Q89551530Pharmacological Inhibition of Caspase-8 Suppresses Inflammation-Induced Angiogenesis in the Cornea
Q101138707Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation
Q49991844Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization.

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