Doxepin inhibits GPVI-dependent platelet Ca2+ signaling and collagen-dependent thrombus formation

scientific article published on 12 April 2017

Doxepin inhibits GPVI-dependent platelet Ca2+ signaling and collagen-dependent thrombus formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00262.2016
P8608Fatcat IDrelease_ufuzyvghffgh3npjc5zwasayu4
P698PubMed publication ID28404545

P50authorFlorian LangQ87017686
Oliver BorstQ117266809
P2093author name stringPatrick Münzer
Meinrad Gawaz
Britta Walker-Allgaier
Daniela Eißler
Malte Schaub
Roland Tegtmeyer
Sascha Geue
P2860cites workInhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral arteryQ46892256
PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In VivoQ48658561
Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosisQ48970037
Antihistaminic drug bromadryl and stimulated platelet aggregation.Q51633250
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.Q51757699
EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis.Q51799143
Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo.Q51831538
Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion.Q53516281
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.Q54342161
Orai1-induced store-operated Ca2+entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine plateletsQ57987842
A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivityQ58291548
Platelet granules: surprise packagesQ58413557
Structure of the human histamine H1 receptor complex with doxepinQ24595968
Platelet-collagen interaction: is GPVI the central receptor?Q28185377
Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarctionQ28345555
Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activationQ28512827
Thrombocytopenia Following Doxepin TreatmentQ33468553
Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study.Q33677302
Effect of serotonin on platelet function in cocaine exposed bloodQ34001485
Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanismsQ34025145
Platelet response to serotonin in patients with stable coronary heart diseaseQ34034485
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applicationsQ34117398
Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acidQ34388429
Platelets in atherothrombosisQ34986345
Platelet serotonin modulates immune functionsQ35563685
Association between haemorrhages and treatment with selective and non-selective serotonergic antidepressants: Possible implications of quantitative signal detectionQ35712744
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoQ36370457
Platelet aggregation and histamine release by immunological stimuliQ36676227
Novel therapeutic usage of low-dose doxepin hydrochlorideQ36904871
Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function.Q37148767
A serotonin-induced N-glycan switch regulates platelet aggregationQ37205659
Calcium signaling in plateletsQ37473529
Low-dose doxepin: in the treatment of insomniaQ37775613
Effect of Antidepressant Doxepin on Ca²⁺ Homeostasis and Viability in PC3 Human Prostate Cancer CellsQ38870612
Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-κB pathway in bronchial epithelial cellsQ39578642
Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humansQ40006101
Ca2+ as messenger of 5HT2-receptor stimulation in human blood plateletsQ42456978
Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.Q42574744
Doxepin plasma concentrations: is there really a therapeutic range?Q43586626
Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formationQ44037490
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregationQ44225925
Histamine potentiates human platelet aggregation induced by platelet-activating factorQ44378089
A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human plateletsQ45609263
The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivoQ46778214
P433issue6
P304page(s)C765-C774
P577publication date2017-04-12
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleDoxepin inhibits GPVI-dependent platelet Ca2+ signaling and collagen-dependent thrombus formation
P478volume312

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Q64122036Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targetingcites workP2860