Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis

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Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00401-017-1669-Y
P698PubMed publication ID28130638

P50authorYili WuQ56391082
Weihong SongQ42153702
P2093author name stringLi Chen
Jie Chen
Zhe Wang
Qian Chen
Tingyu Li
Zhen Fan
Lan Ren
Hongpeng Jiang
Jiaying Zeng
P2860cites workVitamin A: biomarkers of nutrition for developmentQ24629945
Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsQ24633400
Maternal and child undernutrition: consequences for adult health and human capitalQ24642106
Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retractionQ28181660
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivoQ43051937
Increased expression of the amyloid precursor beta-secretase in Alzheimer's diseaseQ44060098
Marginal vitamin A deficiency affects lung maturation in rats from prenatal to adult stageQ44440079
Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.Q44555815
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's diseaseQ44722202
Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brainQ45014651
Vitamin A deficiency impairs postnatal cognitive function via inhibition of neuronal calcium excitability in hippocampusQ45603529
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic MiceQ46143430
Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived ratsQ46986299
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acidQ48054926
Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen speciesQ48390009
Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's diseaseQ48437807
Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.Q48560260
The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 miceQ50746796
Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesisQ50902089
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.Q52608158
Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin.Q53358084
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor proteinQ28260479
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathyQ28288090
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspectiveQ29614702
Maternal and child undernutrition and overweight in low-income and middle-income countriesQ29617926
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypesQ30530899
Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's diseaseQ30719950
Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats.Q33378488
Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticityQ33944863
Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signallingQ34267967
Global malnutritionQ34270019
Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysisQ34379154
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosisQ34554154
Vitamin A supplementation in early life enhances the intestinal immune response of rats with gestational vitamin A deficiency by increasing the number of immune cellsQ34681947
Evidence for defective retinoid transport and function in late onset Alzheimer's diseaseQ34809021
Fetal and placental size and risk of hypertension in adult lifeQ35170031
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionQ35214758
Relationship between eating disturbance and dementia severity in patients with Alzheimer's diseaseQ35743549
All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signalingQ36049939
Long-term effects of nutritional programming of the embryo and fetus: mechanisms and critical windowsQ36772052
The role of microglia in amyloid clearance from the AD brainQ36841789
Retinoic acid in the development, regeneration and maintenance of the nervous systemQ36946560
Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor proteinQ37025855
Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavageQ37239146
Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.Q37352348
Evidence for impaired amyloid β clearance in Alzheimer's diseaseQ37690374
The neurobehavioral teratology of retinoids: A 50‐year historyQ37791998
Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.Q39661608
Regulation of secretases by all-trans-retinoic acidQ39846093
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretinQ39895248
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsQ39924456
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndromeQ40260424
Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcriptionQ40322589
Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cellsQ40376035
Distinct transcriptional regulation and function of the human BACE2 and BACE1 genesQ40429845
Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.Q40581861
Regulation of β-amyloid precursor protein and inositol 1,4,5-trisphosphate receptor gene expression during differentiation of a human neuronal cell lineQ40656071
Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonistQ40755303
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Leaky scanning and reinitiation regulate BACE1 gene expressionQ42091639
P433issue6
P921main subjectAlzheimer's diseaseQ11081
vitamin A deficiencyQ2655893
P304page(s)967-982
P577publication date2017-01-27
P1433published inActa NeuropathologicaQ343168
P1476titleMarginal vitamin A deficiency facilitates Alzheimer's pathogenesis
P478volume133

Reverse relations

cites work (P2860)
Q60595360A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling
Q89960798Association of Circulating Retinol and α-TOH Levels with Cognitive Function in Aging Subject with Type 2 Diabetes Mellitus
Q60595359BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis
Q89683589Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention
Q42148788Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study.
Q47965428Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes
Q89879977Lipids and Alzheimer's Disease
Q41665323Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease
Q64860569Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation
Q92082162Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease
Q91762131Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease
Q92510457The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients
Q48095241The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism
Q47992068Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer's Disease in a Murine Model
Q64966903Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease.
Q58725822Vitamin A Deficiency and the Lung
Q90738238Vitamin A deficiency increases the risk of gastrointestinal comorbidity and exacerbates core symptoms in children with autism spectrum disorder

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