Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process

scientific article published in August 1988

Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0092-8674(88)80006-0
P698PubMed publication ID3136928

P2093author name stringDonahue TF
Cigan AM
Pabich EK
Valavicius BC
P2860cites workStructure of the beta subunit of translational initiation factor eIF-2Q22254876
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Detection of specific sequences among DNA fragments separated by gel electrophoresisQ25939003
57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomasQ28294528
Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotesQ28608933
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomesQ29618470
[12] One-step gene disruption in yeastQ29642800
Initiation factors in protein biosynthesisQ34056839
mRNA structures influencing translation in the yeast Saccharomyces cerevisiaeQ36786647
Genetic selection for mutations that reduce or abolish ribosomal recognition of the HIS4 translational initiator regionQ36792263
Mutational analysis of the HIS4 translational initiator region in Saccharomyces cerevisiaeQ36792286
How do eucaryotic ribosomes select initiation regions in messenger RNA?Q37870587
Sequence and structural features associated with translational initiator regions in yeast--a reviewQ39693814
Eukaryotic protein synthesisQ39826645
Vector systems for the expression, analysis and cloning of DNA sequences in S. cerevisiaeQ39845155
Potential metal-binding domains in nucleic acid binding proteinsQ43519683
The structure and history of an ancient protein / Richard E. Dickerson. - (4.1972)Q47728443
A short nucleotide sequence required for regulation of HIS4 by the general control system of yeastQ48400866
The nucleotide sequence of the HIS4 region of yeastQ48405179
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.Q54454456
Fractionation of rabbit liver methionyl-tRNA speciesQ69355236
Eukaryotic initiation factor 2 from rat liver: no apparent function for the beta-subunit in the formation of initiation complexesQ69613649
Bifunctional messenger RNAs in eukaryotesQ69660482
Eviction and transplacement of mutant genes in yeastQ70160213
21 β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeastQ70165899
DNA rearrangements associated with a transposable element in yeastQ72861678
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)621-632
P577publication date1988-08-01
P1433published inCellQ655814
P1476titleMutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process
P478volume54

Reverse relations

cites work (P2860)
Q26852951'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)
Q35815713A consideration of alternative models for the initiation of translation in eukaryotes
Q33969815A dominant mutation in the Chlamydomonas reinhardtii nuclear gene SIM30 suppresses translational defects caused by initiation codon mutations in chloroplast genes
Q27876228A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo
Q27933536A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast
Q28569233ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner
Q27936010Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases
Q37716795Aminoacyl-tRNA synthetase family from prokaryotes and eukaryotes: structural domains and their implications
Q27929946An aminoacylation-dependent nuclear tRNA export pathway in yeast
Q35585982An anticodon sequence mutant of Escherichia coli initiator tRNA: possible importance of a newly acquired base modification next to the anticodon on its activity in initiation
Q28567490Analysis of a murine male germ cell-specific transcript that encodes a putative zinc finger protein
Q50793369Binding of ATP and messenger RNA by the β-subunit of eukaryotic initiation factor 2
Q28141855Biochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchange
Q36662543Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae
Q24301835Characterization of mammalian eIF2A and identification of the yeast homolog
Q34719928Characterization of yeast translation initiation factor 1A and cloning of its essential gene
Q67700168Chloroplast translational initiation factor 3. Purification and characterization of multiple forms from Euglena gracilis
Q36796132Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs
Q24336236Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
Q27936662Complex formation by positive and negative translational regulators of GCN4.
Q34775434Components of the multifactor complex needed for internal initiation by the IRES of hepatitis C virus inSaccharomyces cerevisiae
Q35948019Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex
Q33890632Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.
Q42073086Conserved sequences in the beta subunit of archaeal and eukaryal translation initiation factor 2 (eIF2), absent from eIF5, mediate interaction with eIF2gamma
Q36300078Control of translation initiation in Saccharomyces cerevisiae
Q40443890Cytoplasmic mRNA-protein interactions in eukaryotic gene expression
Q28592368Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
Q38697728Deletion of eIF2β lysine stretches creates a dominant negative that affects the translation and proliferation in human cell line: A tool for arresting the cell growth
Q67671787Distinct epitopes in eukaryotic initiation factor 2 for binding of mRNA and for ternary complex formation with methionyl-tRNAf and GTP
Q52240106Domains of initiator tRNA and initiation codon crucial for initiator tRNA selection by Escherichia coli IF3
Q28572217Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha
Q37629201Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.
Q28297357Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes
Q36560705Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation
Q27937984Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae
Q68278069Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae
Q44755191Functional molecular mapping of archaeal translation initiation factor 2.
Q34408049Functional significance and mechanism of eIF5-promoted GTP hydrolysis in eukaryotic translation initiation
Q27934490GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae
Q27939500GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae
Q27936437GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
Q27935355GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae
Q57243224Gene overexpression reveals alternative mechanisms that induce GCN4 mRNA translation
Q40654686Gene products that promote mRNA turnover in Saccharomyces cerevisiae
Q35534771Genetic approaches to the study of mitochondrial biogenesis in yeast
Q57243225Genetic evidence for functional specificity of the yeast GCN2 kinase
Q24323068Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction
Q27937750Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5
Q33789786Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery
Q28304019Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences
Q72069131In-vitro translation of mitochondrial mRNAs by yeast mitochondrial ribosomes is hampered by the lack of start-codon recognition
Q72827445Initiation of protein synthesis in eukaryotes
Q33777524Initiation of protein synthesis in mammalian cells with codons other than AUG and amino acids other than methionine
Q33772477Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis
Q24813138Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.
Q36839129Intracellular messengers and the control of protein synthesis
Q78445932Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function
Q27935210Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit
Q61453082MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2
Q36875727Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae
Q24634693Mechanism and regulation of eukaryotic protein synthesis
Q49159867Mechanism of action of developmentally regulated sea urchin inhibitor of eIF-4.
Q40465418Methionine Deprivation Regulates the Translation of Functionally-Distinct c-Myc Proteins
Q34612559Minimum requirements for the function of eukaryotic translation initiation factor 2.
Q36555932Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes
Q34349489Molecular Mechanisms Leading to Null-Protein Product from Retinoschisin (RS1) Signal-Sequence Mutants in X-Linked Retinoschisis (XLRS) Disease
Q35534788Molecular biology of translation in yeast
Q35192105Molecular mechanism of scanning and start codon selection in eukaryotes
Q67949592Mutation analysis of the Cys-X2-Cys-X19-Cys-X2-Cys motif in the beta subunit of eukaryotic translation initiation factor 2
Q47316471Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.
Q33853114Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons
Q37697264Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.
Q27939935Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation
Q41294081Mutations in the NKXD consensus element indicate that GTP binds to the gamma-subunit of translation initiation factor eIF2.
Q34307998Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA
Q27937580Nip1p associates with 40 S ribosomes and the Prt1p subunit of eukaryotic initiation factor 3 and is required for efficient translation initiation
Q42608024Non-AUG translation initiation of mRNA encoding acidic ribosomal P2A protein in Candida albicans
Q39715332Non-canonical translation mechanisms in plants: efficient in vitro and in planta initiation at AUU codons of the tobacco mosaic virus enhancer sequence
Q36602621Phosphorylation and dephosphorylation of human myristoyltransferase type 1.
Q37635118Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis
Q27937074Posttranscriptional control of gene expression in yeast.
Q34186295Power of Yeast for Analysis of Eukaryotic Translation Initiation
Q43812394Protection of translation initiation factor eIF2 phosphorylation correlates with eIF2-associated glycoprotein p67 levels and requires the lysine-rich domain I of p67.
Q35228905Protein Phosphorylation in Translational Control
Q33770503RNA polymerase I-promoted HIS4 expression yields uncapped, polyadenylated mRNA that is unstable and inefficiently translated in Saccharomyces cerevisiae
Q24515333Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2.
Q33886566Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6.
Q27938548Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae.
Q72827465Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2
Q38782862Regulatory mechanisms in translational control
Q35340115Repeat-associated non-AUG translation and its impact in neurodegenerative disease
Q36559289Roles of yeast eIF2α and eIF2β subunits in the binding of the initiator methionyl-tRNA.
Q37586281SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2 zinc finger motif
Q48169666SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3
Q27936940STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs
Q40018796SUI1/p16 is required for the activity of eukaryotic translation initiation factor 3 in Saccharomyces cerevisiae
Q27937717Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2
Q27649026Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states
Q27643172Structure of the archaeal translation initiation factor aIF2 from Methanobacterium thermoautotrophicum: Implications for translation initiation
Q22254876Structure of the beta subunit of translational initiation factor eIF-2
Q27678199Structure of the ternary initiation complex aIF2-GDPNP-methionylated initiator tRNA
Q35420394Structure, function, evolution of transcription factor IIIA
Q42235787Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing
Q37541012The 5'-untranslated region of picornaviral genomes
Q36561380The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2.
Q40656567The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis
Q27937473The Mof2/Sui1 protein is a general monitor of translational accuracy
Q43228789The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function.
Q27936964The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif
Q27638673The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
Q37726434The molecular basis of translational control
Q46143724The phosphorylation state of the wheat translation initiation factors eIF4B, eIF4A, and eIF2 is differentially regulated during seed development and germination
Q34386878The role of eIF1 in translation initiation codon selection in Caenorhabditis elegans
Q40639075The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.
Q24679648The scanning model for translation: an update
Q24630664The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon
Q24651419The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells
Q64942886Toward a Kinetic Understanding of Eukaryotic Translation.
Q36762549Translation in Saccharomyces cerevisiae: initiation factor 4E-dependent cell-free system
Q41288768Translation in plants--rules and exceptions
Q27937611Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.
Q36949922Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.
Q36724411Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases
Q38335001Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae
Q36696456Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
Q48166624Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation
Q38867847Translational control by 5'-untranslated regions of eukaryotic mRNAs
Q41575247Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
Q21146394Unanticipated antigens: translation initiation at CUG with leucine
Q39723771Upf1 and Upf2 proteins mediate normal yeast mRNA degradation when translation initiation is limited
Q27932147Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.
Q57266784Zinc is required for structural stability of the C-terminus of archaeal translation initiation factor aIF2β
Q24621040cDNA sequences of two inducible T-cell genes
Q33959896cis- and trans-acting suppressors of a translation initiation defect at the cyc1 locus of Saccharomyces cerevisiae
Q27930296eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
Q39617540eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

Search more.