Oroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells.

scientific article published on 19 September 2017

Oroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCP.26198
P698PubMed publication ID28926106

P50authorQinglong GuoQ87633337
P2093author name stringZhiyu Li
Kai Zhao
Xiaorui Li
Na Lu
Yuxin Zhou
Dawei Yang
Binyan Lin
P2860cites workAutophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalizationQ22009127
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsQ24291278
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartmentsQ24299236
Angiogenesis in cancer and other diseasesQ27861015
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Mechanisms of angiogenesisQ29547485
Molecular regulation of angiogenesis and lymphangiogenesisQ29616150
Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.Q30636655
Looking for a good endothelial addressQ31089288
Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis GeorgiQ33880655
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell linesQ33904514
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisQ34022315
VEGFR2 signalling contributes to increased endothelial susceptibility to TNF-α under chronic non-uniform shear stressQ34054468
Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis.Q34191596
R-Ras protein inhibits autophosphorylation of vascular endothelial growth factor receptor 2 in endothelial cells and suppresses receptor activation in tumor vasculatureQ35221530
Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational ModelQ35661415
Small GTPase R-Ras regulates integrity and functionality of tumor blood vesselsQ36174151
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinomaQ36809567
The addition of bevacizumab to standard chemotherapy in breast cancer: which patient benefits the most?Q36865945
VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysisQ37631630
Coordination of VEGF receptor trafficking and signaling by coreceptors.Q38090234
Tumor vessel normalization by chloroquine independent of autophagy.Q38966643
Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylationQ39779218
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesisQ40713163
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesisQ43072819
R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesisQ46803107
Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages.Q53503581
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.Q54285640
Endocytosis regulates VEGF signalling during angiogenesis.Q54446981
VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartmentQ58035861
Use of the mouse aortic ring assay to study angiogenesisQ58313759
Epithelial Damage and Angiogenesis in the Airways of Children with AsthmaQ58877196
P433issue4
P304page(s)3454-3464
P577publication date2017-10-27
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleOroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells
P478volume233

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cites work (P2860)
Q90526628Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells
Q64934363Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.
Q92535694Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro

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