Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine.

scientific article published on 9 November 2017

Efficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CAS.13438
P932PMC publication ID5765304
P698PubMed publication ID29121415

P50authorMasafumi IkedaQ88949904
Junji FuruseQ89869443
Akiyoshi KasugaQ48621687
P2093author name stringHideaki Takahashi
Takuji Okusaka
Tatsuya Ioka
Daniel J Felitsky
Chigusa Morizane
Fanghong Zhang
Caretha L Creasy
Akiko Todaka
Akira Fukutomi
Mikiro Kobayashi
Shelby Gorman
P2860cites workFeasibility and benefits of second-line chemotherapy in advanced biliary tract cancer: A large retrospective studyQ57422108
Phase II study of second line gemcitabine single chemotherapy for biliary tract cancer patients with 5-fluorouracil refractorinessQ83969569
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependenceQ27852894
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Biliary tract cancers: epidemiology, molecular pathogenesis and genetic risk associations.Q30241563
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular ProfilesQ32173000
Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer.Q33390549
Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in JapanQ33390747
The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinomaQ33441341
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomasQ33581027
Genes and viruses in hepatobiliary neoplasiaQ34110995
Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibitionQ34221658
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancerQ34618537
Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancersQ35023456
Biliary tract cancers: SEOM clinical guidelinesQ36400234
A multicenter phase II study of S-1 for gemcitabine-refractory biliary tract cancerQ36795363
Targeted therapy for biliary tract cancerQ37132750
Systemic therapy for biliary tract cancersQ37151623
Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma.Q37588461
Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 lossQ37623870
Second-line therapy in advanced biliary tract cancer: what should be the standard?Q38115859
Second-line chemotherapy in advanced biliary cancer: a systematic reviewQ38207456
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint BlockadeQ38788877
GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibitionQ39606314
KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patientsQ39820471
Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: A large multicenter study by the Association des Gastro-Entérologues Oncologues.Q40860251
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinomaQ43005729
Randomized phase II study of gemcitabine plus S-1 versus S-1 in advanced biliary tract cancer: a Japan Clinical Oncology Group trial (JCOG 0805).Q44488107
Capecitabine and celecoxib as second-line treatment of advanced pancreatic and biliary tract cancersQ46107145
S-1 monotherapy as first-line treatment in patients with advanced biliary tract cancer: a multicenter phase II studyQ46795508
Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.Q47280618
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.Q52764639
Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine.Q53268257
Genomic spectra of biliary tract cancer.Q53390123
Mutational landscape of intrahepatic cholangiocarcinoma.Q54300991
P433issue1
P304page(s)215-224
P577publication date2017-12-09
P1433published inCancer ScienceQ326125
P1476titleEfficacy and safety of trametinib in Japanese patients with advanced biliary tract cancers refractory to gemcitabine
P478volume109

Reverse relations

cites work (P2860)
Q51763013Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs.
Q60927301Biliary tract cancer: current challenges and future prospects
Q98159763Genetic analysis in the clinical management of biliary tract cancer
Q100490609Overview of current targeted therapy in gallbladder cancer