Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer

scientific article published on 27 March 2017

Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JSO.24624
P932PMC publication ID5509448
P698PubMed publication ID28346693

P50authorDavid E. GerberQ56107235
Muhammad S BegQ92024135
P2093author name stringDavid A Boothman
Ralph J Deberardinis
Xian-Jin Xie
Matthew E Merritt
Daniel Laheru
Richard Leff
Xiumei Huang
Venetia Sarode
Molly A Silvers
Farjana Fattah
Joyce Bolluyt
P2860cites workModulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapyQ27346846
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Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapyQ33753357
Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers.Q33775762
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinomaQ34642090
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachoneQ35880201
DT-diaphorase and cytochrome B5 reductase in human lung and breast tumoursQ36431207
Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC.Q36471467
New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitorsQ36547381
Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpointsQ36673922
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosisQ36695591
Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations.Q36697159
Dose escalation methods in phase I cancer clinical trialsQ37198192
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancersQ37254021
Synergistic effect of ionizing radiation and beta-Lapachone against RKO human colon adenocarcinoma cellsQ37446989
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.Q38726394
Cancer Statistics, 2017.Q39038674
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachoneQ40105438
NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicityQ40899393
Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 HyperactivationQ42409402
Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.Q43240729
Calcium is a key signaling molecule in beta-lapachone-mediated cell deathQ43560312
μ-Calpain Activation in β-Lapachone-Mediated ApoptosisQ44443361
Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.Q45232206
NQO1 expression in pancreatic cancer and its potential use as a biomarkerQ46842656
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreasQ46987425
Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancerQ57272650
Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosisQ57461599
Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected nonsmall cell lung cancer: impact on recurrence and SurvivalQ77376768
BAX and p16INK4A are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancerQ77635783
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repairQ80141901
P433issue1
P921main subjectchemotherapyQ974135
P304page(s)83-88
P577publication date2017-03-27
P1433published inJournal of Surgical OncologyQ1919535
P1476titleUsing a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer
P478volume116

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cites work (P2860)
Q54989340A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology
Q47574066Accelerating progress in the fight against pancreatic cancer Proceedings of the 2017 Leo and Anne Albert Symposium for Pancreatic Cancer Research.
Q90494760Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia
Q89484746Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
Q94561568Napabucasin (BBI 608), a potent chemoradiosensitizer in rectal cancer
Q88646457Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications
Q89340953Treating pancreatic cancer: more antioxidants more problems?
Q50200648Trypanosoma cruzi: death phenotypes induced by ortho-naphthoquinone substrates of the aldo-keto reductase (TcAKR). Role of this enzyme in the mechanism of action of β-lapachone

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