Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system

scientific article published in January 2007

Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/10717540600559510
P698PubMed publication ID17107928

P2093author name stringSuzanne Hermeling
Prashant J Chikhale
Dennis M Killian
P2860cites workIdentification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acidsQ22010207
Selective expression of the large neutral amino acid transporter at the blood-brain barrierQ24672407
Junctions between intimately apposed cell membranes in the vertebrate brainQ24682725
Carrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the L-system amino acid transporter at the blood-brain barrierQ28378235
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)Q28570781
A bioreversible prodrug approach designed to shift mechanism of brain uptake for amino-acid-containing anticancer agentsQ31961736
Modulating blood-brain barrier interactions of amino acid-based anticancer agentsQ33909624
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrierQ34004944
StainingPO2 measurement sites in the rat brain cortex and quantitative morphometry of the surrounding capillariesQ36589392
New approaches to drug delivery through the blood-brain barrierQ40534942
Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary cultureQ41419038
Drug entry into the brainQ41729326
Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculatureQ43638378
Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivityQ47951227
Kinetics of neutral amino acid transport across the blood-brain barrierQ48186517
High levels of P-glycoprotein detected in isolated brain capillariesQ48233025
Diet and uptake of aldomet by the brain: competition with natural large neutral amino acidsQ48265693
Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrierQ48328037
Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier.Q49270919
Drug metabolizing enzymes in the brain and cerebral microvesselsQ57997191
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdrug deliveryQ1392806
P304page(s)25-31
P577publication date2007-01-01
P1433published inDrug DeliveryQ5308838
P1476titleTargeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system
P478volume14

Reverse relations

cites work (P2860)
Q57677287Drug transport across the blood-brain barrier
Q35134086Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity
Q30394357Focused ultrasound-mediated drug delivery through the blood-brain barrier
Q37330041Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
Q52563214Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Q94598829L-Type amino acid transporter 1 as a target for drug delivery
Q36923089LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs
Q42221833LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates
Q37995554Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery
Q38612543Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System
Q37855817Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier
Q37636171Possible therapy for ALS based on the cyanobacteria/BMAA hypothesis
Q37150860Prodrug approaches for CNS delivery
Q48554104Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).
Q90494434Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)
Q36747640Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
Q99711228Toward a Systematic Structural and Functional Annotation of Solute Carriers Transporters-Example of the SLC6 and SLC7 Families

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