Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

scientific article published in August 1985

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042239674
P356DOI10.1038/316748A0
P698PubMed publication ID4033772

P2093author name stringOrkin SH
Ginsburg D
Collins T
Pober JS
Boss JM
P2860cites workTransforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factorQ48388236
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.Q55489964
Modulation of the sis gene transcript during endothelial cell differentiation in vitroQ69894526
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factorQ70998741
Human endothelial cells: use of heparin in cloning and long-term serial cultivationQ71084423
Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequenceQ71718586
Insulin-like growth factor II precursor gene organization in relation to insulin gene familyQ24301476
Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sisQ24601991
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityQ26778490
A simple and very efficient method for generating cDNA librariesQ27860461
57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
Efficient isolation of genes by using antibody probesQ27860543
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAsQ27860573
Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factorQ28266021
Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivoQ28272278
High-Efficiency Cloning of Full-Length cDNAQ29618285
The isolation of structural genes from libraries of eucaryotic DNAQ29618452
The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphomaQ34055662
Statistical characterization of nucleic acid sequence functional domainsQ35674102
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblastsQ37562030
Expression of the sis gene by endothelial cells in culture and in vivoQ37575847
Cultured endothelial cells produce a platelet-derived growth factor-like proteinQ37607799
Transformation of cultured human vascular endothelium by SV40 DNAQ40048008
Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursorQ40135209
Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformationQ42817641
Transformation of NIH 3T3 cells by a human c-sis cDNA cloneQ42819164
Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma VirusQ45797295
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusQ45798186
Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorQ45798365
Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localizationQ48377892
Requirement for a Signal Sequence in Biological Expression of the v- sis OncogeneQ48384899
P433issue6030
P407language of work or nameEnglishQ1860
P304page(s)748-750
P577publication date1985-08-01
P1433published inNatureQ180445
P1476titleCultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
P478volume316

Reverse relations

cites work (P2860)
Q24301879A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells
Q45252517A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains
Q22254308A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family
Q40452916Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells.
Q34194465Acute lung injury. Pathogenesis of intraalveolar fibrosis
Q41508649Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells
Q72791712Altered growth factor expression during toxic proximal tubular necrosis and regeneration
Q40225927An S1 nuclease-sensitive region in the first intron of human platelet-derived growth factor A-chain gene contains a negatively acting cell type-specific regulatory element
Q41942219Angiogenesis and vasculogenesis in treatment of cardiovascular disease.
Q39038155Anti-Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis
Q67658027Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells
Q38705158Cellular hypertrophy and hyperplasia in disorders of the pulmonary circulation
Q48348013Cellular localization of PDGF mRNAs in developing human forebrain
Q33890391Changing concepts of atherogenesis
Q42662928Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA.
Q34255631Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance
Q33719276Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis
Q67476490Connective Tissue Growth Factor
Q33236833Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
Q34564574Constitutive and inducible secretion of platelet-derived growth factor analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers
Q35855846Cultured human endothelial cells express platelet-derived growth factor A chain.
Q30501506Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas
Q35811693Derivation and properties of platelet-derived growth factor-independent rat smooth muscle cells
Q34349538Detection of c-sis proto-oncogene transcripts by direct enzyme-labeled cDNA probes and in situ hybridization
Q70315600Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas
Q43524686Differential expression of PDGF A- and B-chain genes and production of AA and AB dimers by activated human blood monocytes
Q73532160Differential glomerular response to continuous infusion of vasopressin in spontaneously hypertensive rats and Wistar-Kyoto rats
Q41431319Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis
Q47871745Effect of continuous infusion of vasopressin on glomerular growth response in spontaneously hypertensive rats
Q47885784Effects of OPC-21268, a vasopressin V1-receptor antagonist, on expression of growth factors from glomeruli in spontaneously hypertensive rats
Q77844920Elevated platelet-derived growth factor-B in congenital cystic adenomatoid malformations requiring fetal resection
Q39653396Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrier
Q30470375Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression
Q41826183Endothelial stimulation of intimal cell proliferation in a porcine aortic organ culture
Q39641757Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with pulmonary sarcoidosis
Q40983551Excessive activation of tyrosine kinases leads to inhibition of proliferation in a thyroid carcinoma cell line
Q40818075Expression and secretion of gro/MGSA by stimulated human endothelial cells
Q41330817Expression of a 2.8-kb PDGF-B/c-sis Transcript and Synthesis of PDGF-Like Protein by Human Lung Fibroblasts
Q44471371Expression of acidic and basic fibroblast growth factors in human and bovine vascular smooth muscle cells
Q35982942Expression of growth factor receptors in human brain tumours
Q35590941Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines
Q72705394Expression of platelet-derived growth factor and c-myc in atherosclerotic lesions in cholesterol-fed chickens: immunohistochemical and in situ hybridization study
Q28264297Galanin and its receptors in neurological disorders
Q40564964Genetic organization of the c-sis transcription unit
Q39505099Growth factor-mediated proliferative pathways and the neoplastic process
Q38532954Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury
Q72385877Heparin and dibutyryl cAMP modulate gene expression in stimulated human saphenous vein smooth muscle cells
Q42833313Heparin-binding growth factor-1 stimulation of human endothelial cells induces platelet-derived growth factor A-chain gene expression
Q40968459Human malignant fibrous histiocytomas in vitro: growth characteristics and their association with expression of mRNA for platelet-derived growth factor, transforming growth factor-alpha and their receptors
Q37400696Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor
Q41152763Human osteoblasts synthesize and respond to platelet-derived growth factor
Q24634292Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor)
Q36477937Identification and characterization of an essential, activating regulatory element of the human SIS/PDGFB promoter in human megakaryocytes
Q36922350Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules
Q67491650Immunoreactivity for the β chain of the platelet‐derived growth factor receptor in malignant mesothelioma and non‐neoplastic mesothelium
Q42049615In situ detection of platelet-derived growth factor-A and -B chain mRNA in human coronary arteries after percutaneous transluminal coronary angioplasty
Q24558741Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy
Q41362063Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines
Q37376431Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts
Q36425982Isolation and sequencing of a cDNA clone homologous to the v-sis oncogene from human endothelial cells
Q40005235Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling
Q34128848Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells
Q37599429Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products
Q35614606Modified low density lipoproteins suppress production of a platelet-derived growth factor-like protein by cultured endothelial cells
Q34119398Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis
Q41715190Molecular biology of atherosclerosis
Q36397797Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia
Q42738346Monocyte adherence to endothelial cells in vitro is increased by beta-VLDL
Q38746581Oncogenes, protooncogenes, and signal transduction: toward a unified theory?
Q36883640Organization of the thymidylate synthase gene of herpesvirus saimiri
Q70847479PDGF and TGF-beta contribute to the natural course of human IgA glomerulonephritis
Q36223935PDGF ligand and receptor gene expression during repair of arterial injury
Q39212450PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice
Q36234340PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors
Q42558745Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes
Q36914754Phorbol ester induces c-sis gene transcription in stem cell line K-562.
Q24654274Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing
Q72596235Platelet-derived growth factor B-chain gene expression in mesangial cells: effect of phorbol ester on gene transcription and mRNA stability
Q34165679Platelet-derived growth factor BB induces functional vascular anastomoses in vivo
Q39755281Platelet-derived growth factor as a mediator of normal and neoplastic cell proliferation.
Q48515146Platelet-derived growth factor expression in a transgenic model
Q53474392Platelet-derived growth factor expression in accelerated and blastic phase of chronic myelogenous leukaemia with myelofibrosis.
Q34261287Platelet-derived growth factor in idiopathic pulmonary fibrosis
Q35798196Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo.
Q35814834Pressure-induced connective tissue synthesis in pulmonary artery segments is dependent on intact endothelium
Q68352602Production of Platelet-Derived Growth Factor–like Mitogen by Smooth-Muscle Cells from Human Atheroma
Q47349254Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat.
Q28584987Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor
Q34324828Quantitation of mRNA by the polymerase chain reaction
Q73022730Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas
Q40450020Regulation of expression of the c-sis proto-oncogene
Q38319874Role of platelet-derived growth factor in obliterative bronchiolitis (chronic rejection) in the rat.
Q34697186Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences
Q35807682Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages
Q77135834Stimulatory effects of lipoprotein(a) and low-density lipoprotein on human umbilical vein endothelial cell migration and proliferation are partially mediated by fibroblast growth factor-2
Q28645857Structural and functional aspects of platelet-derived growth factor
Q24632602Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins
Q40559828Structure and nucleotide sequence of the 5' region of the human and feline c-sis proto-oncogenes
Q35599098Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit
Q33950287Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
Q38337041Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes
Q72428698Synthesis of platelet-derived growth factor by cells of splenic red pulp in normal rats
Q36780591The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor
Q48367043The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain
Q42571055The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation
Q41740363Therapeutic angiogenesis: a new frontier for vascular therapy
Q35796418Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency
Q67793092Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells
Q58980859Translational activation of the lck proto-oncogene
Q34254204Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis
Q69334509Variability in messenger RNA levels in human umbilical vein endothelial cells of different lineage and time in culture
Q34551601cDNA cloning of human plasminogen activator-inhibitor from endothelial cells
Q24299707cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
Q34146568p53 expression during normal tissue regeneration in response to acute cutaneous injury in swine

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