Production and characterization of fusion proteins containing transferrin and nerve growth factor

scientific article published in January 1998

Production and characterization of fusion proteins containing transferrin and nerve growth factor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3109/10611869808997881
P698PubMed publication ID9769021

P2093author name stringGeorge J
Lee T
Park E
Putney SD
Starzyk RM
McGrath JP
Lynch P
Schutz AJ
P2860cites workAtrophy of cholinergic basal forebrain neurons following excitotoxic cortical lesions is reversed by intravenous administration of an NGF conjugateQ42525170
Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrierQ44785157
Transferrin and iron uptake by the brain: effects of altered iron statusQ45562653
Bifunctional fusion between nerve growth factor and a transferrin receptor antibodyQ48055027
Transferrin receptor on endothelium of brain capillariesQ48602638
Transport of [125I]transferrin through the rat blood-brain barrierQ57677412
Human transferrin: cDNA characterization and chromosomal localizationQ24596395
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factorQ27656280
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomesQ27860600
Receptor-mediated transcytosis of transferrin across the blood-brain barrierQ28303216
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
NGF in CNS: experimental data and clinical implicationsQ30886123
Expression and characterization of an antibody binding specificity joined to insulin-like growth factor 1: potential applications for cellular targetingQ33685694
Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complexQ33827984
Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primateQ34058435
Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug deliveryQ34060172
Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.Q34061528
Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivoQ34239620
Transferrin-antibody fusion proteins are effective in brain targetingQ34506062
Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington diseaseQ35761924
The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factorQ35884401
Recombinant Toxins for Cancer TreatmentQ36533609
Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connectionsQ36936476
Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genesQ37093959
Transcytotic pathway for blood-borne protein through the blood-brain barrierQ37484109
Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrierQ37521936
Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseasesQ38715616
Trophic factors and neuronal survivalQ38772889
The nerve growth factor 35 years laterQ39667849
Folding and association of proteinsQ39696106
Human beta-nerve growth factor gene sequence highly homologous to that of mouseQ40236820
Structural determinants of neurotrophin action.Q40468353
Receptor blockade with monoclonal antibodies as anti-cancer therapyQ40585866
Gene therapy in the central nervous system: direct versus indirect gene deliveryQ40959820
Transport and elimination of recombinant human NGF during long-term delivery to the brainQ41184267
Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowthQ41316837
Nerve growth factor in Alzheimer's disease: to treat or not to treat?Q41330754
High-level expression of various apolipoprotein(a) isoforms by "transferrinfection": the role of kringle IV sequences in the extracellular association with low-density lipoprotein.Q41436201
Rapid endocytosis of the transferrin receptor in the absence of bound transferrinQ41467499
Blood-brain barrier penetration and in vivo activity of an NGF conjugateQ41578400
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiationQ41596156
Nerve growth factor: structure/function relationshipsQ41956129
Sustained Release of Nerve Growth Factor from Biodegradable Polymer MicrospheresQ42461657
Effects of intraventricular encapsulated hNGF-secreting fibroblasts in aged rats.Q42519480
P433issue1
P304page(s)53-64
P577publication date1998-01-01
P1433published inJournal of Drug TargetingQ6295099
P1476titleProduction and characterization of fusion proteins containing transferrin and nerve growth factor
P478volume6

Reverse relations

cites work (P2860)
Q38088357Advances and challenges in developing cytokine fusion proteins as improved therapeutics
Q34019876Endogenous carriers and ligands in non-immunogenic site-specific drug delivery
Q38798702Expression and Purification of Neurotrophin-Elastin-Like Peptide Fusion Proteins for Neural Regeneration
Q43093968In vitro characterization of an acetylcholine receptor-transferrin fusion protein for the treatment of myasthenia gravis
Q39918619Insertion of the designed helical linker led to increased expression of tf-based fusion proteins
Q91801425Microwave Assisted Sol-Gel Synthesis of Silica-Spider Silk Composites
Q35172436New systems for delivery of drugs to the brain in neurological disease
Q24548071Novel nanocomposites from spider silk-silica fusion (chimeric) proteins
Q33713530Recombinant proteins for genetic disease.

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