MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile

scientific article published in December 2000

MSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/LABINVEST.3780201
P698PubMed publication ID11140703
P5875ResearchGate publication ID12187947

P50authorManuel Sobrinho SimõesQ10324505
José C. MachadoQ37829240
Carla OliveiraQ37831347
Fatima CarneiroQ40479058
P2093author name stringR Hamelin
R Seruca
M Pinto
R Hofstra
L Cirnes
J Tavares
P2860cites workDistinct methylation pattern and microsatellite instability in sporadic gastric cancerQ73014737
Mutational analysis of MLH1 and MSH2 in 25 prospectively-acquired RER+ endometrial cancersQ73157872
MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancersQ74595724
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.Q24539206
hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesisQ24670424
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomasQ28288475
Origin of microsatellite instability in gastric cancerQ30444930
The DNA methylation paradoxQ33543982
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.Q33888431
The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genesQ35753518
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.Q36213486
Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical featuresQ41668427
Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumoursQ42112990
Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellitesQ48517465
MSH2 andMLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresisQ57200626
Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosisQ61627303
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomasQ70972741
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancerQ71689243
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instabilityQ72127255
P433issue12
P304page(s)1915-1923
P577publication date2000-12-01
P1433published inLaboratory InvestigationQ6467260
P1476titleMSI-L gastric carcinomas share the hMLH1 methylation status of MSI-H carcinomas but not their clinicopathological profile
P478volume80

Reverse relations

cites work (P2860)
Q35566861A study of molecular signals deregulating mismatch repair genes in prostate cancer compared to benign prostatic hyperplasia
Q40557856Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines
Q54961446Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis.
Q38184380Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?
Q57176090Biomarkers of gastric cancer: Current topics and future perspective
Q34589660Causes and consequences of microsatellite instability in gastric carcinogenesis.
Q37991971Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers
Q54771817Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas.
Q44028985Distinct clinical features and outcomes of gastric cancers with microsatellite instability
Q26741859Gastric biomarkers: a global review
Q57200538MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer
Q36178601Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability
Q39104058Pathogenesis of Gastric Cancer: Genetics and Molecular Classification.
Q30361259Silencing-specific methylation and single nucleotide polymorphism of hMLH1 promoter in gastric carcinomas.
Q58762545The Thomsen-Friedenreich Antigen: A Highly Sensitive and Specific Predictor of Microsatellite Instability in Gastric Cancer
Q64957083The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents.

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