Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions.

scientific article published on 22 August 2012

Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions. is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1016/J.NPEP.2012.07.004
P698PubMed publication ID22921965
P5875ResearchGate publication ID230740918

P2093author name stringJ Whitton
G Giordano
R Lever
P S Whitton
N Rampersaud
A Harkavyi
P2860cites workBrain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleusQ61643489
Acute and chronic effects of 4-chloroamphetamine on monoamine metabolism in the rat brainQ67441060
Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in miceQ71583548
Early diagnosis of Parkinson's diseaseQ80194831
Depression research: where are we now?Q21198902
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's diseaseQ24647189
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synucleinQ26269955
Emotion circuits in the brainQ27860733
Staging of brain pathology related to sporadic Parkinson's diseaseQ28131702
Tyrosine hydroxylase phosphorylation: regulation and consequencesQ28295531
Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosisQ28481242
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosisQ28570314
Parkinson's disease: mechanisms and modelsQ29547424
Parkinson's diseaseQ29616302
Peripheral BDNF produces antidepressant-like effects in cellular and behavioral modelsQ30497021
Cortical networks of procedural learning: evidence from cerebellar damageQ30542121
Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitryQ30975753
Etiology and pathogenesis of Parkinson's diseaseQ33593402
Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacityQ33617472
Post mortem studies in Parkinson's disease--is it possible to detect brain areas for specific symptoms?Q33660662
Role of norepinephrine in the pathophysiology and treatment of mood disordersQ33772708
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's diseaseQ33952130
Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cellsQ34028497
Increased risk of Parkinson's disease after depression: a retrospective cohort studyQ34130645
Learning and memory functions of the Basal GangliaQ34132332
Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic systemQ34395267
Depression in Parkinson's disease -- a reviewQ34478301
A systematic review of depression and mental illness preceding Parkinson's diseaseQ34502729
Brain serotonin transporter binding in non-depressed patients with Parkinson's diseaseQ34619565
Procedural learning and neostriatal dysfunction in man.Q34684107
Spared caudal brainstem SERT binding in early Parkinson's diseaseQ34724279
Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson's diseaseQ34733143
The neuropathological basis for depression in Parkinson's diseaseQ34764454
Noradrenaline and Parkinson's diseaseQ35013240
Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease.Q46346508
Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterationsQ46531059
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation.Q46619925
Nonmotor symptoms in Parkinson's disease: investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat modelQ46706492
Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemesQ46742923
Influence of noradrenaline denervation on MPTP-induced deficits in miceQ46857343
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.Q48170542
The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats.Q48263467
Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system.Q48306367
Pre-training to find a hidden platform in the Morris water maze can compensate for a deficit to find a cued platform in a rat model of Parkinson's disease.Q48309761
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.Q48617135
Cognitive deficits in the early stages of Parkinson's disease.Q48800336
Differential age-related loss of pigmented locus coeruleus neurons in suicides, alcoholics, and alcoholic suicides.Q48903836
Mesolimbic and mesocortical dopaminergic neurons are necessary for normal exploratory behavior in rats.Q49160355
The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.Q50662877
Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats.Q51978130
Does the behavioral "despair" test measure "despair"?Q52263149
Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson's disease with and without dementia and depression.Q53187673
Serotonergic dysfunction in Parkinson's disease and its relevance to disability.Q53188615
Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease.Q55044523
PET imaging of neocortical monoaminergic terminals in Parkinson's diseaseQ59858909
Increased risk of developing Parkinson's disease for patients with major affective disorder: a register studyQ60643572
Disease model: Parkinson's disease.Q35203031
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.Q35209949
Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neuronsQ35320973
A new Alzheimer's disease interventive strategy: GLP-1.Q35843402
Non-motor symptoms of Parkinson's disease: diagnosis and managementQ36400926
Non-motor dysfunction in Parkinson's diseaseQ36756269
Norepinephrine: The redheaded stepchild of Parkinson's diseaseQ36784705
The premotor phase of Parkinson's diseaseQ36903390
Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memoryQ36948136
Non-motor symptoms in Parkinson's diseaseQ37587798
Glucagon-like peptide 1 receptor stimulation as a means of neuroprotectionQ37686556
Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's diseaseQ38493912
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's diseaseQ39124093
Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestorationQ39634067
Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heartQ40026474
Behavioural despair in rats: A new model sensitive to antidepressant treatmentsQ40134604
Glucagon-like peptide-1 prevents beta cell glucolipotoxicityQ40565084
Frontal lobe dysfunction in secondary depressionQ40582885
Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.Q40657491
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cellsQ40748616
Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A.Q40872180
Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: a possible role for the locus coeruleus in the progression of Parkinson's diseaQ41158228
6-hydroxydopamine induces the loss of the dopaminergic phenotype in substantia nigra neurons of the rat. A possible mechanism for restoration of the nigrostriatal circuit mediated by glial cell line-derived neurotrophic factorQ41170164
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's diseaseQ41346993
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neuronsQ42007296
Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis studyQ42455719
Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cellsQ42490271
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.Q42524942
Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat.Q42624819
Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET studyQ42994792
Caffeine prevents disruption of memory consolidation in the inhibitory avoidance and novel object recognition tasks by scopolamine in adult miceQ43018157
Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamineQ43024089
Desipramine attenuates forced swim test-induced behavioral and neurochemical alterations in mice: an in vivo(1)H-MRS study at 9.4T.Q43028260
Rasagiline improves learning and memory in young healthy ratsQ43045852
Molecular profiling of a 6-hydroxydopamine model of Parkinson's diseaseQ43156838
Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficitsQ43167027
MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampusQ43197575
Tryptophan depletion impairs object-recognition memory in the rat: reversal by risperidoneQ43204033
Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's diseaseQ43246435
Is immobility of rats in the forced swim test "behavioral despair"?Q43315896
Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesiaQ43651582
SSRIs in the treatment of depression in Parkinson's diseaseQ44467578
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in ratsQ44489178
Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysisQ44535170
Positron emission tomography of striatal serotonin transporters in Parkinson diseaseQ44585433
P433issue5
P921main subjectParkinson's diseaseQ11085
P304page(s)183-193
P577publication date2012-08-22
P1433published inNeuropeptidesQ15751202
P1476titleExendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions.
P478volume46

Reverse relations

cites work (P2860)
Q36538782Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma.
Q89563105Assessment of serotonergic system in formation of memory and learning
Q93094007Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat
Q49096857Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats.
Q37473323Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.
Q38188177Exenatide as a potential treatment for patients with Parkinson's disease: first steps into the clinic
Q48164658Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
Q50560411Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats.
Q48254506GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats
Q91448321Glucagon-like peptide 1 (GLP-1)
Q61449892Glucose Homeostasis Is Not Affected in a Murine Model of Parkinson's Disease Induced by 6-OHDA
Q33603384Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
Q91143521Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4
Q38149622Incretin actions beyond the pancreas: lessons from knockout mice
Q51713596Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases.
Q38807899Insulin resistance and Parkinson's disease: A new target for disease modification?
Q38105048Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?
Q38668948Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases
Q90769540Protective Effects of Incretin Against Age-Related Diseases
Q90358913Recent Advances in Drug Repurposing for Parkinson's Disease
Q90264679Reduced Sensory-Evoked Locus Coeruleus-Norepinephrine Neural Activity in Female Rats With a History of Dietary-Induced Binge Eating
Q38708302Tactile learning in rodents: Neurobiology and neuropharmacology
Q50891658Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats.
Q26768527The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
Q38275171The ongoing pursuit of neuroprotective therapies in Parkinson disease
Q98774928Therapeutic strategies for Parkinson's disease: promising agents in early clinical development

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