Introduction of a fluorescent probe to amyloid-β to reveal kinetic insights into its interactions with copper(II).

scientific article published on 21 December 2014

Introduction of a fluorescent probe to amyloid-β to reveal kinetic insights into its interactions with copper(II). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201408810
P698PubMed publication ID25529008
P5875ResearchGate publication ID269820300

P50authorPaul GirvanQ86366540
Liming YingQ38318472
Mauricio BarahonaQ40862215
P2093author name stringThomas Branch
P2860cites workpH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.Q42726192
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.Q43236403
Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.Q43244535
Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.Q45982880
Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principlesQ46887798
Copper modulation of NMDA responses in mouse and rat cultured hippocampal neuronsQ48873258
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.Q53274559
Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.Q53291427
Cu(II) affinity for the Alzheimer's peptide: tyrosine fluorescence studies revisited.Q53335554
Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β PeptidesQ58045283
Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β PeptidesQ58045285
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeuticsQ29614972
Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.Q30331574
Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptideQ33397015
Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Q34438376
Alzheimer's disease & metals: therapeutic opportunitiesQ34919551
The metallobiology of Alzheimer's diseaseQ35104793
The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's diseaseQ35216515
Neuroenergetics and the kinetic design of excitatory synapses.Q36302344
Rate theories for biologistsQ36520904
Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled AβQ36653725
The redox chemistry of the Alzheimer's disease amyloid beta peptide.Q36791163
Therapeutics for Alzheimer's disease based on the metal hypothesisQ37215856
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptideQ37423906
Amyloidogenic protein-membrane interactions: mechanistic insight from model systemsQ37771927
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothesQ37979641
The missing link in the amyloid cascade of Alzheimer's disease - metal ionsQ38080353
Chemical kinetics for drug discovery to combat protein aggregation diseasesQ38190285
The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activityQ39499173
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1227-1230
P577publication date2014-12-21
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleIntroduction of a fluorescent probe to amyloid-β to reveal kinetic insights into its interactions with copper(II)
P478volume54

Reverse relations

cites work (P2860)
Q48723756A Single Biosensor for Evaluating the Levels of Copper Ion and L-Cysteine in a Live Rat Brain with Alzheimer's Disease.
Q46726802Aggregation-Prone Amyloid-β⋅Cu(II) Species Formed on the Millisecond Timescale under Mildly Acidic Conditions.
Q48048483Copper binding and redox chemistry of the Aβ16 peptide and its variants: insights into determinants of copper-dependent reactivity.
Q90189518Cu2+ Effects on Beta-Amyloid Oligomerisation Monitored by the Fluorescence of Intrinsic Tyrosine
Q46261288Identifying Cu(ii)-amyloid peptide binding intermediates in the early stages of aggregation by resonance Raman spectroscopy: a simulation study.
Q55330860Ionic liquids in protein amyloidogenesis: a brief screenshot of the state-of-the-art.
Q41690668Kinetic Analysis Reveals the Identity of Aβ-Metal Complex Responsible for the Initial Aggregation of Aβ in the Synapse
Q41673954Kinetics of the Interactions between Copper and Amyloid-β with FAD Mutations and Phosphorylation at the N terminus.
Q91667311Monitoring metal-amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening
Q45327210Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level.
Q50036711N-terminal Cu Binding Motifs Xxx-Zzz-His (ATCUN) and Xxx-His and their derivatives: Chemistry, Biology and Medicinal Applications.
Q28818161Numerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic Synapses

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