A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats.

scientific article published on 19 September 2006

A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/TOXSCI/KFL113
P698PubMed publication ID16984958
P5875ResearchGate publication ID6809393

P50authorHelen HåkanssonQ71007440
P2093author name stringAldert H Piersma
Leo T M van der Ven
Theo J Visser
Aart Verhoef
Wout Slob
Pim E G Leonards
Maria Herlin
Timo Hamers
Josephus G Vos
Hanna Olausson
Ton van de Kuil
P2860cites workRegulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidismQ28584995
Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitroQ31399638
The thyroxine-binding proteinsQ33863834
An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of releaseQ34212627
The retinoid signaling system--a target in dioxin toxicityQ34692833
Risk assessment of thyroid follicular cell tumorsQ34939457
Toxic effects of brominated flame retardants in man and in wildlifeQ35172736
Are brominated flame retardants endocrine disruptors?Q35172744
The molecular actions of thyroid hormone in boneQ35546577
Functional protein-protein interaction of drug metabolizing enzymesQ35966417
Peripheral metabolism of thyroid hormone and glucose homeostasisQ36244519
Mechanistic data and risk assessment of selected toxic end points of the thyroid glandQ36849669
The analysis of organ weight dataQ36882432
Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD).Q42729728
Distribution and fate of HBCD and TBBPA brominated flame retardants in North Sea estuaries and aquatic food webs.Q43317384
Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antQ43609150
Temporal trend studies on tetra- and pentabrominated diphenyl ethers and hexabromocyclododecane in guillemot egg from the Baltic Sea.Q44724026
Modulation at a cellular level of the thyroid hormone receptor-mediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4'-diiodobiphenyl (DIB), and nitrofen (NIP).Q45178172
Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450.Q46472118
Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in ratsQ46834319
Relationships between organ weight and body/brain weight in the rat: what is the best analytical endpoint?Q47416285
Dose-response modeling of continuous endpoints.Q52044652
A simulation study of the influence of study design on the estimation of benchmark doses for developmental toxicity.Q52201383
In vitro profiling of the endocrine-disrupting potency of brominated flame retardants.Q52569861
Allometric analysis of organ weights. I. RatsQ52857152
The state-of-the-science and trends of brominated flame retardants in the environment: present knowledge and future directions.Q53782989
Polybrominated dibenzo-p-dioxins and dibenzofurans: the flame retardant issueQ56431835
P433issue2
P304page(s)281-292
P577publication date2006-09-19
P1433published inToxicological SciencesQ2446966
P1476titleA 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats
P478volume94

Reverse relations

cites work (P2860)
Q428504291,2,5,6,9,10-αHexabromocyclododecane (HBCD) impairs thyroid hormone-induced dendrite arborization of Purkinje cells and suppresses thyroid hormone receptor-mediated transcription.
Q36640291Acute effects of hexabromocyclododecane on Leydig cell cyclic nucleotide signaling and steroidogenesis in vitro
Q28390549Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates
Q36873509Bone mineral density changes in relation to environmental PCB exposure
Q52585517Brominated flame retardants as possible endocrine disrupters.
Q34580183Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells
Q89376636Complete genome sequence of Bacillus sp. HBCD-sjtu, an efficient HBCD-degrading bacterium
Q30514104Effects of chronic exposure to an environmentally relevant mixture of brominated flame retardants on the reproductive and thyroid system in adult male rats.
Q42710047Effects of low-level hexabromocyclododecane (HBCD) exposure on cardiac development in zebrafish embryos
Q38590683Endocrine disruptors and obesity
Q35448074Evaluation of arecoline hydrobromide toxicity after a 14-day repeated oral administration in Wistar rats
Q33569487Exposure to hexabromocyclododecanes (HBCDs) via dust ingestion, but not diet, correlates with concentrations in human serum: preliminary results
Q48194766Flame retardants, hexabromocyclododecane (HCBD) and tetrabromobisphenol a (TBBPA), alter secretion of tumor necrosis factor alpha (TNFα) from human immune cells.
Q56968360Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD)
Q34160878Halogenated flame retardants: do the fire safety benefits justify the risks?
Q36619978Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells
Q37456902Hexabromocyclododecane decreases the lytic function and ATP levels of human natural killer cells
Q33876048Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells
Q42709187Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells
Q42445985Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells
Q58094813Hexabromocyclododecane: concentrations and isomer profiles from sources to environmental sinks
Q37627583Impaired lipid and glucose homeostasis in hexabromocyclododecane-exposed mice fed a high-fat diet
Q48302719Impairment in the mesohippocampal dopamine circuit following exposure to the brominated flame retardant, HBCDD.
Q57653743Kinetic study of γ-hexabromocyclododecane orally given to laying hens (Gallus domesticus)
Q87115241NMR- and LC-MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice
Q47890353Neuroprotection by Taurine on HBCD-Induced Apoptosis in PC12 Cells
Q55893642POPs and Human Health Risk Assessment
Q47572573Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity
Q51858088Perinatal exposure to environmental contaminants detected in Canadian Arctic human populations changes bone geometry and biomechanical properties in rat offspring.
Q36072551Policy relevant results from an expert elicitation on the human health risks of decabromodiphenyl ether (decaBDE) and hexabromocyclododecane (HBCD).
Q47150396Scientific Opinion on Hexabromocyclododecanes (HBCDDs) in Food
Q36366275Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD
Q37738907Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture
Q39147874The cytological effects of HBCDs on human hepatocyte L02 and the potential molecular mechanism
Q37000039The fate of β-hexabromocyclododecane in female C57BL/6 mice
Q38992221The inadequacies of pre-market chemical risk assessment's toxicity studies-the implications.
Q57653661Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-HBCDD) in Laying Hens (Gallus domesticus)
Q28307982Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism
Q28285713Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, route, repeated exposure, and metabolism
Q48616126Transient aberration of neuronal development in the hippocampal dentate gyrus after developmental exposure to brominated flame retardants in rats.
Q46769407Uptake, distribution, depletion, and in ovo transfer of isomers of hexabromocyclododecane flame retardant in diet-exposed American kestrels (Falco sparverius).
Q42708207Use of an avian hepatocyte assay and the avian Toxchip Polymerse chain reaction array for testing prioritization of 16 organic flame retardants

Search more.