Phase II study of MEDI-575, an anti-platelet-derived growth factor-α antibody, in patients with recurrent glioblastoma

scientific article published on 14 November 2016

Phase II study of MEDI-575, an anti-platelet-derived growth factor-α antibody, in patients with recurrent glioblastoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11060-016-2287-6
P8608Fatcat IDrelease_eefqy2yizzewlitzmqylu5ua5m
P698PubMed publication ID27844311

P2093author name stringJeffrey Raizer
Marc Chamberlain
Shengyan Hong
Surasak Phuphanich
Rajesh Narwal
Robert Miday
Kevin Laubscher
Minal Nade
Paola Canelos
P2860cites workEffects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
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Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterationsQ30885944
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PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomasQ34164924
A phase I dose-escalation study of MEDI-575, a PDGFRα monoclonal antibody, in adults with advanced solid tumorsQ34403375
Rituximab monotherapy for patients with recurrent primary CNS lymphomaQ34686155
Therapeutic approaches for HER2-positive brain metastases: circumventing the blood-brain barrier.Q35608531
Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.Q37345320
Immune heterogeneity of glioblastoma subtypes: extrapolation from the cancer genome atlasQ37435455
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrierQ37819809
Platelet-derived growth factor in glioblastoma-driver or biomarker?Q38262433
Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancerQ39171073
Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trialsQ40789890
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomideQ43290402
Salvage therapy with single agent bevacizumab for recurrent glioblastoma.Q45931836
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working groupQ48271471
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumorsQ48445033
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loopsQ48478557
P433issue1
P304page(s)185-191
P577publication date2016-11-14
P1433published inJournal of Neuro-OncologyQ15752119
P1476titlePhase II study of MEDI-575, an anti-platelet-derived growth factor-α antibody, in patients with recurrent glioblastoma
P478volume131

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cites work (P2860)
Q57111067Glioblastoma Treatments: An Account of Recent Industrial Developments
Q100959515Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation
Q57291853Targeted Theranostic Nanoparticles for Brain Tumor Treatment

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