Altered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease.

scientific article published on 10 May 2012

Altered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000338181
P698PubMed publication ID22572791

P50authorKaj BlennowQ28321550
P2093author name stringN Bogdanovic
J-E Månsson
M Blomqvist
Z Pernber
P2860cites workAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranesQ24532064
Amyloid plaque core protein in Alzheimer disease and Down syndromeQ24568384
Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotypeQ24642852
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tauQ24648590
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid raftsQ24675729
Functional rafts in cell membranesQ27860768
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
Neuropathological stageing of Alzheimer-related changesQ27860862
Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteriaQ29614410
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's diseaseQ29614948
Lipid rafts as a membrane-organizing principleQ29615727
Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.Q48770929
Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous gangliosideQ48934855
Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.Q48951456
Structure and origin of ordered lipid domains in biological membranes.Q52186070
Human brain gangliosides: developmental changes from early fetal stage to advanced age.Q52244920
Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.Q52539745
GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.Q53199612
Tau protein and neurodegeneration.Q53298110
Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.Q53389202
Structural transitions associated with the interaction of Alzheimer beta-amyloid peptides with gangliosides.Q54144813
Frontotemporal dementiaQ56388056
Alzheimer's diseaseQ29616743
Abeta polymerization through interaction with membrane gangliosides.Q33527686
Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).Q33694188
Lipid rafts and membrane dynamicsQ33985713
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid raftsQ34088442
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor proteinQ34649008
The effects of normal aging on myelin and nerve fibers: a reviewQ35539049
Plasma membrane microdomains: organization, function and traffickingQ35809659
Consequences of NPC1 and NPC2 loss of function in mammalian neuronsQ35909562
GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloidQ36136370
Age-related neuropathology, cognitive decline, and Alzheimer's diseaseQ36220917
The involvement of lipid rafts in Alzheimer's diseaseQ36447798
Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysisQ36472868
The molecular pathology of Alzheimer's diseaseQ36490940
Lipid rafts in health and diseaseQ36634331
Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a reviewQ36662671
Lipid rafts and membrane trafficQ36768730
Frontotemporal lobar degeneration: clinical and pathological relationshipsQ36849424
Membrane rafts in Alzheimer's disease beta-amyloid productionQ37715176
Characterization of high-affinity binding between gangliosides and amyloid beta-proteinQ38300563
The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranesQ38348598
Association of active gamma-secretase complex with lipid rafts.Q40457156
GM1 ganglioside regulates the proteolysis of amyloid precursor proteinQ40571948
Normal and abnormal biology of the beta-amyloid precursor proteinQ40766055
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloidQ40807391
Gangliosides in cerebrospinal fluid in 'probable Alzheimer's disease'.Q42018527
Characterization of the binding epitope of a monoclonal antibody to sulphatideQ42164330
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomainsQ43889089
Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloidQ44014100
Expression of the myelin and oligodendrocyte progenitor marker sulfatide in neurons and astrocytes of adult rat brainQ44059825
Up-and-down topological mode of amyloid beta-peptide lying on hydrophilic/hydrophobic interface of ganglioside clustersQ44522032
Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domainsQ45192504
Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's diseaseQ46076619
Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortexQ46839219
CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survivalQ46878198
Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brainQ47268422
A detergent-insoluble membrane compartment contains A beta in vivoQ47982783
Atypical glial cells in demyelinated and hypomyelinated mouse brainsQ48144630
GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neuronsQ48270632
Differential distribution of major gangliosides in rat central nervous system detected by specific monoclonal antibodiesQ48308074
Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons.Q48657258
P433issue2-3
P921main subjectAlzheimer's diseaseQ11081
P1104number of pages15
P304page(s)174-188
P577publication date2012-05-10
P1433published inDementia and Geriatric Cognitive DisordersQ15749436
P1476titleAltered distribution of the gangliosides GM1 and GM2 in Alzheimer's disease.
P478volume33

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cites work (P2860)
Q92651158Amyloid Oligomers, Protofibrils and Fibrils
Q37243920Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier
Q41074727Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
Q34555955Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
Q55438475Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer's Disease.
Q36226843Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.
Q28391606Hippocampal lipid differences in Alzheimer's disease: a human brain study using matrix-assisted laser desorption/ionization-imaging mass spectrometry
Q28278644Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease
Q35576628Myelin basic protein associates with AβPP, Aβ1-42, and amyloid plaques in cortex of Alzheimer's disease brain
Q35915842Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease
Q35192627Neurological analyses: focus on gangliosides and mass spectrometry
Q39176826Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates.
Q38218040Pathogenic role of ganglioside metabolism in neurodegenerative diseases
Q38125769Progress towards a consensus on biomarkers for Alzheimer's disease: a review of peripheral analytes.
Q34031193Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes
Q47785630Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload
Q38691207The Pathogenic Role of Ganglioside Metabolism in Alzheimer's Disease-Cholinergic Neuron-Specific Gangliosides and Neurogenesis
Q43988916The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease
Q92193049Trends in Glycolipid Biomarker Discovery in Neurodegenerative Disorders by Mass Spectrometry

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