Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats

scientific article

Intrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YHBEH.2006.03.003
P698PubMed publication ID16631174

P2093author name stringCheryl A Frye
Kassandra L Edinger
P2860cites workSpecific binding sites for [3H]Ro 5-4864 in rat prostate and seminal vesicleQ67503068
Behavioral effects of 3 alpha-androstanediol. I: Modulation of sexual receptivity and promotion of GABA-stimulated chloride fluxQ71710864
Behavioral effects of 3 alpha-androstanediol. II: Hypothalamic and preoptic area actions via a GABAergic mechanismQ71710868
[Maximal androgen blockade]Q73420301
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the ratQ29619517
Testosterone and andropause: the feasibility of testosterone replacement therapy in elderly men.Q33715924
Direct effects of the anabolic/androgenic steroids, stanozolol and 17α-methyltestosterone, on benzodiazepine binding to the γ-aminobutyric acidA receptorQ34299309
Treatment with an anabolic-androgenic steroid affects anxiety-related behavior and alters the sensitivity of cortical GABAA receptors in the rat.Q34348670
Anxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptorsQ34421784
The neurobiology of conditioned and unconditioned fear: a neurobehavioral system analysis of the amygdalaQ35801808
Andropause (or symptomatic late-onset hypogonadism): facts, fiction and controversiesQ36084039
Epidemiology of women and depressionQ40599444
The inhibitory effect of diazepam on defensive burying: anxiolytic vs. analgesic effectsQ41339351
Time-course and steroid specificity of aromatase induction in rat hypothalamus-preoptic areaQ41465462
Mood disorders and menopauseQ41507863
Anxiety, defence and the elevated plus-mazeQ41672220
Developmental regulation of the distribution of aromatase- and estrogen-receptor- mRNA-expressing cells in the zebra finch brainQ41715034
Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male ratsQ42631365
Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP.Q42641575
Testosterone increases analgesia, anxiolysis, and cognitive performance of male ratsQ42689717
Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviorsQ42689728
The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water mazeQ43562312
Testosterone rapidly reduces anxiety in male house mice (Mus musculus).Q44253217
Anticonvulsant Effect of Flutamide on Seizures Induced by Pentylenetetrazole: Involvement of Benzodiazepine ReceptorsQ44444513
Orchidectomy sensitizes male rats to the action of diazepam on burying behavior latency: role of testosterone.Q44520737
Andropause and psychopathology: minor symptoms rather than pathological onesQ44533510
5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male ratsQ44953297
One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men.Q44953310
Mnemonic effects of testosterone and its 5alpha-reduced metabolites in the conditioned fear and inhibitory avoidance tasksQ44976332
Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugsQ45011857
Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formationQ45160926
Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampusQ45186575
Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampusQ45274016
Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brainQ46442478
Immunocytochemical localization of androgen receptors in brains of developing and adult male rhesus monkeysQ47835167
Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brainQ48376538
Evidence that estradiol-2/4-hydroxylase activities in rat hypothalamus and hippocampus differ qualitatively and involve multiple forms of P-450: ontogenetic and inhibition studiesQ48428814
Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat.Q48658403
High doses of testosterone increase anticonflict behaviour in rat.Q48705525
Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brainQ48770888
Age-associated testosterone decline in men: clinical issues for psychiatryQ48787028
Elective ovarian removal and estrogen replacement therapy--effects on sexual life, psychological well-being and androgen status.Q51138830
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.Q51139011
Gonadectomy enhances shock-induced behavioral inhibition in adult male rats: implications for impulsive behavior.Q51406922
Conditioned defensive burying: A new paradigm for the study of anxiolytic agentsQ51865752
Ontogenetic expression and sex differences of aromatase and estrogen receptor-alpha/beta mRNA in the mouse hippocampus.Q52167376
Rejuvenation in the early 20th centuryQ62111696
Testosterone replacement therapy for anxiety.Q64895798
P433issue2
P304page(s)216-222
P577publication date2006-04-24
P1433published inHormones and BehaviourQ15760887
P1476titleIntrahippocampal administration of an androgen receptor antagonist, flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats
P478volume50

Reverse relations

cites work (P2860)
Q211310733alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats
Q36948697Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance
Q36326556Androgen receptors, sex behavior, and aggression
Q34822652Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
Q36652472Anxiolytic-like Effect of Testosterone in Male Rats: GABAC Receptors Are Not Involved
Q39638691Aromatized testosterone attenuates contextual generalization of fear in male rats
Q88736639Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice
Q37220801Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats
Q37324578Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats
Q34136074Differences between trait fear and trait anxiety: Implications for psychopathology
Q33569784Down, But Not Out: Partial Elimination of Androgen Receptors in the Male Mouse Brain Does Not Affect Androgenic Regulation of Anxiety or HPA Activity
Q37276053Examining the intersection of sex and stress in modelling neuropsychiatric disorders
Q61807707Female-biased sexual dimorphism of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis
Q47985347Flutamide treatment induces anxiolytic-like behavior in adult castrated rats
Q48496232Gonadectomy differentially regulates steroid receptor coactivator-1 and synaptic proteins in the hippocampus of adult female and male C57BL/6 mice
Q36036762Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring
Q55388869Intrinsic links among sex, emotion, and reproduction.
Q37194196Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?
Q30464114Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress
Q37733065Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens
Q46650018Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors
Q38869219Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis
Q34972115New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice.
Q58799071On the Role of Testosterone in Anxiety-Like Behavior Across Life in Experimental Rodents
Q37034882Organizational and activational effects of testosterone on masculinization of female physiological and behavioral stress responses
Q36868218Ovariectomy and chronic stress lead toward leptin resistance in the satiety centers and insulin resistance in the hippocampus of Sprague-Dawley rats.
Q36391526Sex differences and sex hormones in anxiety-like behavior of aging rats
Q37625151Sex differences in anxiety and depression: role of testosterone
Q44544429Sex steroid hormones modulate responses to social challenge and opportunity in males of the monogamous convict cichlid, Amatitliana nigrofasciata
Q48066217Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress
Q42691159Testosterone promotes anxiolytic-like behavior in gonadectomized male rats via blockade of the 5-HT1A receptors
Q35850540The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats
Q26824098The dominance behavioral system and psychopathology: evidence from self-report, observational, and biological studies
Q28087544The impact of nandrolone decanoate on the central nervous system
Q30468950The organizational role of testicular hormones and the androgen receptor in anxiety-related behaviors and sensorimotor gating in rats

Search more.