A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey

scientific article published in August 1997

A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-8993(97)00531-3
P698PubMed publication ID9359593

P50authorErwan BezardQ38544252
P2093author name stringBioulac B
Gross CE
Imbert C
Deloire X
P2860cites workChronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
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Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkeyQ28270776
Core assessment program for intracerebral transplantations (CAPIT)Q28295664
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivoQ28306009
Chronic parkinsonism secondary to intravenous injection of meperidine analoguesQ28323857
Oral levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys: assessment with a new rating scale for monkey parkinsonismQ28328337
Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal systemQ34248307
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MPTP mechanisms of neurotoxicity and their implications for Parkinson's diseaseQ37045190
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ37343442
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Neuronal basis of the parkinsonian resting tremor: a hypothesis and its implications for treatmentQ37945591
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Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonistsQ41154685
Striatal dopamine deficiency in Parkinson's disease: role of agingQ41993839
Parkinson's disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesionsQ42436109
Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP.Q43624609
Tremor in MPTP-induced parkinsonismQ46130176
Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeysQ48316612
Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q48321963
Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosetsQ48347120
MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primatesQ48446938
Deficits in behavioral initiation and execution processes in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonismQ48460759
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemiaQ48468018
MPTP primate model of Parkinson's disease: a mechanographic and electromyographic studyQ48486914
MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studiesQ48593461
Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonismQ48626940
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboonsQ48937244
Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeysQ48951590
Differential recovery of volitional motor function, lateralized cognitive function, dopamine agonist-induced rotation and dopaminergic parameters in monkeys made hemi-parkinsonian by intracarotid MPTP infusion.Q52210070
The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine to monkeysQ57809499
Distribution of Catecholamines in the Ventral Mesencephalon of Human Brain, with Special Reference to Parkinson's DiseaseQ64785695
Presymptomatic revelation of experimental parkinsonism.Q67217591
Increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin MPTPQ69227608
Further treatment with MPTP does not produce parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxinQ69246322
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ70951248
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot studyQ71149834
Pretreatment with nimodipine prevents MPTP-induced neurotoxicity at the nigral, but not at the striatal level in miceQ71860224
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)107-112
P577publication date1997-08-01
P1433published inBrain ResearchQ4955782
P1476titleA chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkey
P478volume766