Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia

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Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2015.06.016
P698PubMed publication ID26162854
P5875ResearchGate publication ID279988087

P50authorKirsi RillaQ38804560
P2093author name stringArto Koistinen
Markku Tammi
Riikka Kärnä
Ville Koistinen
Antti Arjonen
P2860cites workHyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogelsQ21090839
Myosin-X is a molecular motor that functions in filopodia formationQ24299253
Filopodia and adhesion in cancer cell motilityQ26823315
Tissue distribution and subcellular localization of hyaluronan synthase isoenzymesQ28590024
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush bordersQ28593765
The many faces of actin: matching assembly factors with cellular structuresQ29620433
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.Q30572690
Parallel actin bundles and their multiple actin-bundling proteins.Q33786549
ERM proteins at a glanceQ33980498
Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.Q34003991
Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixinQ34421034
Role of microvillar cell surfaces in the regulation of glucose uptake and organization of energy metabolismQ34462651
Shaping the intestinal brush borderQ34566715
Cellular control of actin nucleationQ34762557
Ultrastructural analysis of nanogold-labeled cell surface microvilli in liquid by atmospheric scanning electron microscopy and their relevance in cell adhesionQ35019976
The mesothelial cellQ35573234
Myosin-X: a MyTH-FERM myosin at the tips of filopodiaQ35576442
Fascin protrusions in cell interactionsQ35903278
Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophilaQ36095728
Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo.Q36324725
Oocyte-follicle cell interactions during ovarian follicle development, as seen by high resolution scanning and transmission electron microscopy in humansQ36485706
Hyaluronan synthases: a decade-plus of novel glycosyltransferasesQ36992644
Organization of hyaluronan and versican in the extracellular matrix of human fibroblasts treated with the viral mimetic poly I:C.Q37389406
Filopodia as sensorsQ38123322
Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancerQ38235796
Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulationQ38345893
Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagenQ38383300
Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophyQ39230067
Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activityQ39364616
HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.Q39429868
Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusionsQ39968916
Hyaluronan synthesis induces microvillus-like cell surface protrusionsQ40295784
Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3Q40631967
Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane RufflesQ41833126
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Hyaluronan production enhances shedding of plasma membrane-derived microvesiclesQ42439454
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.Q43240565
Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survivalQ44168152
Src-dependent tyrosine phosphorylation at the tips of growth cone filopodia promotes extension.Q46656549
Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding.Q51070229
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.Q52604153
Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3Q57957367
Increased HAS2-driven hyaluronic acid synthesis in shar-pei dogs with hereditary cutaneous hyaluronosis (mucinosis)Q60639817
Histologic, morphometric study of the human synovial membraneQ67900541
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)179-191
P577publication date2015-07-07
P1433published inExperimental Cell ResearchQ1524289
P1476titleCell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia
P478volume337

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cites work (P2860)
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Q46425720Hyaluronan synthase assembles hyaluronan on a [GlcNAc(β1,4)]n-GlcNAc(α1→)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end.
Q53192237Hyaluronan-positive plasma membrane protrusions exist on mesothelial cells in vivo.
Q88409472Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa
Q91630402Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy
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Q26747455The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases?

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