Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis.

scientific article

Statins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GLIA.21245
P698PubMed publication ID21964955

P50authorPeter J Van den ElsenQ40683739
Jeffrey BajramovicQ56794153
P2093author name stringIvanela Kondova
Hedwich F Kuipers
Ella A Zuiderwijk-Sick
Céline Van Der Putten
Linda Van Straalen
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Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRsQ24303416
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophagesQ24561388
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A new mathematical model for relative quantification in real-time RT-PCRQ27860781
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Differential effects of statins on relevant functions of human monocyte-derived dendritic cellsQ33230637
Statins as potential therapeutic agents in neuroinflammatory disordersQ34213875
Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosisQ34784810
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How Toll-like receptors signal: what we know and what we don't knowQ36339101
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Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitisQ37084467
Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosisQ37139712
Statin therapy inhibits remyelination in the central nervous system.Q37164252
Regulation of innate immune responses in the central nervous system.Q37818408
Effects of statins on microgliaQ40381858
Statins affect cell-surface expression of major histocompatibility complex class II molecules by disrupting cholesterol-containing microdomainsQ40402794
Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trialQ43057997
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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune diseaseQ43934617
Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factorsQ43963606
Statins as immunomodulators: comparison with interferon-beta 1b in MS.Q44172256
Broad expression of Toll-like receptors in the human central nervous systemQ44492400
Oral simvastatin treatment in relapsing-remitting multiple sclerosisQ44897670
Statins enhance toll-like receptor 4-mediated cytokine gene expression in astrocytes: implication of Rho proteins in negative feedback regulationQ44932595
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microgliaQ45057128
Lovastatin modulation of microglial activation via suppression of functional CD40 expressionQ45066194
Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC.Q45178138
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses.Q45221796
Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.Q45983873
Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expressionQ46433219
Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytesQ46463155
Simvastatin affects cell motility and actin cytoskeleton distribution of microgliaQ46736945
Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo.Q46916581
Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo.Q48743494
TLR signaling tailors innate immune responses in human microglia and astrocytesQ57041985
Statins as a newly recognized type of immunomodulatorQ73252634
Pravastatin down-regulates inflammatory mediators in human monocytes in vitroQ73337591
Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatinQ78076743
[Toll-like receptor]Q81455322
P433issue1
P921main subjecttoll-like receptorQ408004
microgliaQ1622829
microglial inhibitorQ63100844
P304page(s)43-52
P577publication date2011-09-30
P1433published inGliaQ15716658
P1476titleStatins amplify TLR-induced responses in microglia via inhibition of cholesterol biosynthesis
P478volume60

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cites work (P2860)
Q38396167Alternative methods for the use of non-human primates in biomedical research
Q58799132An Overview of Methods to Study Microglia
Q64914715Pretreatment with simvastatin upregulates expression of BK-2R and CD11b in the ischemic penumbra of rats.
Q41848796Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms
Q36058919Toll-like receptor (TLR) and inflammasome actions in the central nervous system

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