Forskolin modulates acetylcholine receptor gating by interacting with the small extracellular loop between the M2 and M3 transmembrane domains

scientific article published in October 2000

Forskolin modulates acetylcholine receptor gating by interacting with the small extracellular loop between the M2 and M3 transmembrane domains is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1053511827
P356DOI10.1023/A:1007011911611
P698PubMed publication ID10930133

P2093author name stringZ Chen
M M White
P2860cites workIdentification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channelQ28379427
The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptorQ30424904
The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channelQ33638576
Control of Torpedo acetylcholine receptor biosynthesis in Xenopus oocytesQ33672766
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cellsQ35372931
Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currentsQ36410283
A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.Q37574995
The multiple phenotypes of allosteric receptor mutantsQ37703420
d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptorQ37734944
Mutagenesis of the GABA rho 1 receptor alters agonist affinity and channel gatingQ38307359
Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channelsQ40386612
Voltage jump analysis of procaine action at frog end-plateQ40650028
Local anaesthetics transiently block currents through single acetylcholine-receptor channelsQ40676934
Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo.Q41138563
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.Q41142209
Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.Q42279580
An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptorQ42615025
Mapping the alpha-subunit site photolabeled by the noncompetitive inhibitor [3H]quinacrine azide in the active state of the nicotinic acetylcholine receptorQ42636959
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptorsQ42680472
Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptorQ43866558
Forskolin alters acetylcholine receptor gating by a mechanism independent of adenylate cyclase activation.Q44218783
An analog of lophotoxin reacts covalently with Tyr190 in the alpha-subunit of the nicotinic acetylcholine receptorQ44899939
A residue in the middle of the M2-M3 loop of the beta4 subunit specifically affects gating of neuronal nicotinic receptors.Q48932719
The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gatingQ49041704
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptorsQ50792913
Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells.Q51811998
Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.Q51860256
Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonistQ68225987
Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kineticsQ68981303
Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMPQ69029580
Stimulation of adenylate cyclase by water-soluble analogues of forskolinQ69077980
Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding siteQ70620848
Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptorQ71634386
Selective enhancement of the interaction of curare with the nicotinic acetylcholine receptorQ72890087
Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptorQ73959929
P433issue5
P921main subjecttransmembrane proteinQ424204
P304page(s)569-577
P577publication date2000-10-01
P1433published inCellular and Molecular NeurobiologyQ2333197
P1476titleForskolin modulates acetylcholine receptor gating by interacting with the small extracellular loop between the M2 and M3 transmembrane domains
P478volume20

Reverse relations

cites work (P2860)
Q44082378Direct noncompetitive inhibition of 5-HT(3) receptor-mediated responses by forskolin and steroids
Q35342444Isoflurane alters the structure and dynamics of GLIC.
Q43772584Photoaffinity labeling of adenylyl cyclase

Search more.