Apolipoprotein E genotype regulates amyloid-beta cytotoxicity.

scientific article published in April 2005

Apolipoprotein E genotype regulates amyloid-beta cytotoxicity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.4213-04.2005
P932PMC publication ID6725371
P698PubMed publication ID15814793

P2093author name stringMarcel M Verbeek
Irene Otte-Höller
Judianne Davis
William E Van Nostrand
Micha M M Wilhelmus
Robert M W de Waal
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Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's diseaseQ24682442
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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's diseaseQ29614948
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.Q31949934
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell lineQ33848287
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrierQ33928434
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3Q34229659
Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous systemQ34559847
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer diseaseQ34662682
Specific regional transcription of apolipoprotein E in human brain neuronsQ35745315
Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's diseaseQ35774045
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitroQ35834037
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer diseaseQ36604545
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloidQ36707976
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's diseaseQ36784564
Enhanced pathologic properties of Dutch-type mutant amyloid beta-proteinQ37683153
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.Q40528558
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's diseaseQ40849918
A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.Q40965861
A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteinsQ41056322
Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursorQ41442753
Accumulation of the amyloid-beta precursor protein in multivesicular body-like organelles.Q41917662
Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: implications for cerebral amyloid angiopathyQ41927992
Induction of alpha-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-beta 1.Q42754593
Inhibition of amyloid-beta-induced cell death in human brain pericytes in vitroQ44167757
Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytesQ44693513
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathyQ44822600
Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cellsQ46096613
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptidesQ47349499
Apolipoprotein E in cerebrospinal fluid: relation to phenotype and plasma apolipoprotein E concentrationsQ48248632
Human brain pericytes as a model system to study the pathogenesis of cerebrovascular amyloidosis in Alzheimer's disease.Q48250504
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.Q48477194
Nascent astrocyte particles differ from lipoproteins in CSF.Q48478094
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's diseaseQ48633197
Rapid degeneration of cultured human brain pericytes by amyloid beta protein.Q48793512
Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's diseaseQ49171338
Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.Q53224959
Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample.Q53310511
Heparan sulfate proteoglycan expression in cerebrovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains.Q53350049
Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filamentsQ59053832
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
P304page(s)3621-3627
P577publication date2005-04-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleApolipoprotein E genotype regulates amyloid-beta cytotoxicity
P478volume25

Reverse relations

cites work (P2860)
Q35662397Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway
Q35474565Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis
Q39257249Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease
Q52606699Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury.
Q57023036Blood-Brain Barrier: From Physiology to Disease and Back
Q57810850Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
Q36961152Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease
Q37133530Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice
Q42044152Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease
Q36202900Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
Q36448521Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models
Q36330352Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress
Q26740342Role of ROS and RNS Sources in Physiological and Pathological Conditions
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Q40822165Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity
Q43243545apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

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