| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1996Sci...271.1592V |
| P356 | DOI | 10.1126/SCIENCE.271.5255.1592 |
| P698 | PubMed publication ID | 8599117 |
| P5875 | ResearchGate publication ID | 14601668 |
| P2093 | author name string | Mizuuchi K | |
| Gellert M | |||
| van Gent DC | |||
| P433 | issue | 5255 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1592-1594 | |
| P577 | publication date | 1996-03-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Similarities between initiation of V(D)J recombination and retroviral integration | |
| P478 | volume | 271 |
| Q34303871 | A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals |
| Q33958478 | A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination |
| Q39719591 | A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences |
| Q77195640 | A preferred target DNA structure for retroviral integrase in vitro |
| Q34547234 | A recombinase diversified: new functions of the RAG proteins |
| Q34295816 | A role for secondary V(D)J recombination in oncogenic chromosomal translocations? |
| Q38349361 | A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage |
| Q38329553 | Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. |
| Q51803328 | Amino acid residues in Rag1 crucial for DNA hairpin formation. |
| Q33889534 | An ATP-ADP switch in MuB controls progression of the Mu transposition pathway |
| Q27648444 | An Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telomeres |
| Q46107069 | Antigen receptor gene rearrangement |
| Q28275539 | Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination |
| Q34290414 | Assembly of the RAG1/RAG2 synaptic complex |
| Q96607405 | Biochemical activity of RAGs is impeded by Dolutegravir, an HIV integrase inhibitor |
| Q40402552 | Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro |
| Q28081315 | Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates |
| Q41101441 | Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. |
| Q33966887 | Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination |
| Q77734518 | Contributions of CD4+, CD8+, and CD4+CD8+ T cells to skewing within the peripheral T cell receptor beta chain repertoire of healthy macaques |
| Q41429654 | Control of immunoglobulin gene rearrangements in developing B cells |
| Q35970972 | Control of transposase activity within a transpososome by the configuration of the flanking DNA segment of the transposon |
| Q36684764 | Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA. |
| Q41044013 | Cutting apart V(D)J recombination |
| Q24791637 | Cyclic changes in the affinity of protein-DNA interactions drive the progression and regulate the outcome of the Tn10 transposition reaction |
| Q40907770 | Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair |
| Q33652023 | DNA hairpin opening mediated by the RAG1 and RAG2 proteins |
| Q36562940 | DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences |
| Q47750695 | DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations |
| Q30479923 | DNA transposition target immunity and the determinants of the MuB distribution patterns on DNA |
| Q28751993 | DNA transposons: nature and applications in genomics |
| Q28140723 | Degradation of HIV-1 integrase by the N-end rule pathway |
| Q33958242 | Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking |
| Q28366147 | Determinants for hairpin formation in Tn10 transposition |
| Q34552628 | Developmentally programmed excision of internal DNA sequences in Paramecium aurelia |
| Q44017740 | Direct observation of single MuB polymers: evidence for a DNA-dependent conformational change for generating an active target complex |
| Q39728013 | Directional binding of HMG-I(Y) on four-way junction DNA and the molecular basis for competitive binding with HMG-1 and histone H1. |
| Q35852678 | Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage |
| Q33775546 | Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences |
| Q40668121 | Do retroviruses preferentially integrate within highly plastic regions of the human genome? |
| Q35188701 | Drosophila P-element transposase is a novel site-specific endonuclease |
| Q64286620 | Early life exposures, neurodevelopmental disorders, and transposable elements |
| Q33896796 | Effect of HIV integrase inhibitors on the RAG1/2 recombinase |
| Q77990761 | Epigenetic interactions among three dTph1 transposons in two homologous chromosomes activate a new excision-repair mechanism in petunia |
| Q33775068 | Extensive, nonrandom diversity of excision footprints generated by Ds-like transposon Ascot-1 suggests new parallels with V(D)J recombination |
| Q34296487 | Factors and forces controlling V(D)J recombination |
| Q39677703 | Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals |
| Q48717960 | Focal contributions to molecular biophysics and structural biology: a personal view. Part III. |
| Q38348176 | Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration |
| Q33775583 | Functional analysis of coordinated cleavage in V(D)J recombination |
| Q74473323 | Functional characterization of the Tn5 transposase by limited proteolysis |
| Q37783743 | Genome duplication and T cell immunity |
| Q34693905 | Genomic instability due to V(D)J recombination-associated transposition. |
| Q34050694 | HIV-1 integrase inhibitors: past, present, and future |
| Q33644040 | HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro |
| Q38329558 | Hairpin coding end opening is mediated by RAG1 and RAG2 proteins |
| Q24294409 | Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination |
| Q33205906 | Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. |
| Q32067274 | How to make ends meet in V(D)J recombination |
| Q33995584 | Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells |
| Q34718124 | Identification and characterization of a gain-of-function RAG-1 mutant |
| Q52081212 | Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. |
| Q74293115 | Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination |
| Q24798897 | Identifying related L1 retrotransposons by analyzing 3' transduced sequences |
| Q33821742 | Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing |
| Q28235295 | Immunology in the spotlight at the Dover 'Intelligent Design' trial |
| Q40567174 | In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining |
| Q34794778 | In vivo transposition mediated by V(D)J recombinase in human T lymphocytes |
| Q29617579 | Insertion sequences |
| Q35023166 | Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. |
| Q37884414 | Interactions of host proteins with the murine leukemia virus integrase |
| Q33948953 | Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends. |
| Q38321453 | Involvement of DNA end-binding protein Ku in Ty element retrotransposition |
| Q41821763 | Ku80 is required for immunoglobulin isotype switching |
| Q36567784 | Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products |
| Q38354165 | Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates |
| Q36037736 | Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences |
| Q33960582 | Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination |
| Q33938490 | Mobile elements and the human genome |
| Q52565366 | Molecular architecture of a eukaryotic DNA transposase. |
| Q35210006 | Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination |
| Q33964869 | Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies |
| Q28510756 | Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase |
| Q39038472 | New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination |
| Q34641788 | Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage |
| Q37790458 | Nucleases: diversity of structure, function and mechanism. |
| Q34090070 | Ordered assembly of the V(D)J synaptic complex ensures accurate recombination |
| Q33459180 | Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity |
| Q77355835 | Phylogenetic emergence and molecular evolution of the immunoglobulin family |
| Q47108181 | Physiological Roles of DNA Double-Strand Breaks |
| Q33934189 | Playing second fiddle: second-strand processing and liberation of transposable elements from donor DNA. |
| Q37352542 | Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases |
| Q40976980 | Quality control in Mu DNA transposition |
| Q53616216 | RAG and HMGB1 proteins: purification and biochemical analysis of recombination signal complexes. |
| Q36573841 | RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution |
| Q33958065 | RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex |
| Q40033943 | RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule |
| Q28307236 | RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination |
| Q34288648 | RAG1 and RAG2 in V(D)J recombination and transposition |
| Q21092810 | RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons |
| Q41157754 | RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination |
| Q73989887 | RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences |
| Q33968434 | Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination |
| Q41430421 | Recent advances in understanding V(D)J recombination. |
| Q34985886 | Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2 |
| Q42111003 | Regulation of activator/dissociation transposition by replication and DNA methylation |
| Q33702230 | Resident aliens: the Tc1/mariner superfamily of transposable elements |
| Q36949688 | Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors |
| Q35219034 | Restraining the V(D)J recombinase |
| Q34668065 | Retroviral Integrase Structure and DNA Recombination Mechanism |
| Q41029973 | Retroviral integrase, putting the pieces together |
| Q42642005 | Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination |
| Q64388530 | Single active site catalysis of the successive phosphoryl transfer steps by DNA transposases: insights from phosphorothioate stereoselectivity |
| Q35616738 | Site-specific DNA transesterification catalyzed by a restriction enzyme |
| Q34389437 | Site-specific recombination by the DDE family member mobile element IS30 transposase |
| Q41353188 | Specificity in V(D)J recombination: new lessons from biochemistry and genetics |
| Q41701981 | Stereospecificity of reactions catalyzed by HIV-1 integrase |
| Q33886633 | Stimulation of V(D)J cleavage by high mobility group proteins |
| Q39631050 | Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination |
| Q27655283 | Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis |
| Q33263575 | Target DNA structure plays a critical role in RAG transposition |
| Q31164008 | Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors |
| Q33966875 | The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination |
| Q54676348 | The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. |
| Q38332454 | The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step |
| Q28277487 | The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination |
| Q73353796 | The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination |
| Q41078625 | The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products. |
| Q38924256 | The application of fluorescence-conjugated pyrrole/imidazole polyamides in the characterization of protein-DNA complex formation |
| Q36177454 | The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination |
| Q41032621 | The effect of Me2+ cofactors at the initial stages of V(D)J recombination |
| Q56903271 | The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination |
| Q39016663 | The impact of transposable elements on mammalian development |
| Q34619795 | The mechanism and regulation of chromosomal V(D)J recombination |
| Q33919197 | The old and the restless |
| Q41329165 | The origins of V(D)J recombination |
| Q36369521 | The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo |
| Q22122375 | The role of selfish genetic elements in eukaryotic evolution |
| Q27617962 | The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution |
| Q28756514 | Transposable elements and the dynamic somatic genome |
| Q41011364 | Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system |
| Q33736014 | Transposition mediated by RAG1 and RAG2 and the evolution of the adaptive immune system |
| Q52654190 | Transposition of hAT elements links transposable elements and V(D)J recombination. |
| Q48664281 | Uncovering the V(D)J recombinase |
| Q34292616 | Unraveling V(D)J recombination; insights into gene regulation |
| Q38535955 | V(D)J Recombination: Mechanism, Errors, and Fidelity |
| Q54749851 | V(D)J recombination and RAG-mediated transposition in yeast. |
| Q34630089 | V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element |
| Q73574910 | V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation |
| Q38334568 | V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2. |
| Q37769914 | V(D)J recombination: Born to be wild |
| Q36573432 | V(D)J recombination: in vitro coding joint formation |
| Q24324082 | V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins |
| Q77198189 | VDJ recombination: a transposase goes to work |
| Q42850240 | Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system |
| Q36570713 | piggyBac can bypass DNA synthesis during cut and paste transposition |
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