Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production

scientific article published on 19 October 2016

Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00311.2016
P932PMC publication ID5283885
P698PubMed publication ID27760767

P2093author name stringKaren L Hile
Kirstan K Meldrum
Futoshi Matsui
Hongji Zhang
Audrey Rhee
Stephen A Babitz
P2860cites workThe role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal diseaseQ26825424
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Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanismsQ31147648
Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 releaseQ33283747
Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cellsQ33703700
IL-18 induces profibrotic renal tubular cell injury via STAT3 activationQ33816800
Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstructionQ34347818
Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repairQ34357753
Progression of chronic renal diseaseQ34614030
Arterially transplanted mesenchymal stem cells in a mouse reversible unilateral ureteral obstruction model: in vivo bioluminescence imaging and effects on renal fibrosisQ34722231
Conditioned mesenchymal stem cells attenuate progression of chronic kidney disease through inhibition of epithelial-to-mesenchymal transition and immune modulationQ35370283
Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiationQ35746896
Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR.Q35920540
Identification and characterization of a fibroblast marker: FSP1Q36382596
Mesenchymal stem cells and endothelial progenitor cells decrease renal injury in experimental swine renal artery stenosis through different mechanismsQ36484420
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.Q36986233
Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells.Q37278443
Therapeutic applications of mesenchymal stem cells to repair kidney injuryQ37755843
Kidney protection and regeneration following acute injury: progress through stem cell therapyQ38049450
The gap between the physiological and therapeutic roles of mesenchymal stem cellsQ38215374
Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trialQ38474282
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathyQ38494989
Clinical Trials With Mesenchymal Stem Cells: An Update.Q38596084
Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine actionQ39268273
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathyQ39697103
Arterially Delivered Mesenchymal Stem Cells Prevent Obstruction-Induced Renal FibrosisQ41418374
Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice.Q42495926
Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trialsQ42727596
Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury.Q45152925
Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failureQ47302183
In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemia.Q48924966
Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model.Q50597496
Bone Marrow-Derived Mesenchymal Stem Cells and Their Conditioned Medium Attenuate Fibrosis in an Irreversible Model of Unilateral Ureteral Obstruction.Q51053705
Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathyQ52603651
Human adipose tissue-derived mesenchymal stem cells protect kidneys from cisplatin nephrotoxicity in rats.Q53195886
Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis.Q53616452
Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury.Q54668933
Pathophysiology of Progressive NephropathiesQ57703963
Molecular insights into renal interstitial fibrosisQ57741419
Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injuryQ58831554
Transdifferentiation: a new angle on renal fibrosisQ71808756
Role of tubule epithelial cells in the pathogenesis of tubulointerstitial fibrosis induced by glomerular diseaseQ77565813
Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstructionQ81583826
Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-β signalling via secretion of bone morphogenetic protein 7Q87913674
P433issue1
P921main subjectmesenchymal stem cellQ1922379
renal fibrosisQ18553516
P304page(s)F25-F32
P577publication date2016-10-19
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleMesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production
P478volume312

Reverse relations

cites work (P2860)
Q64055054CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway
Q58799997Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
Q90725973Human Liver Stem Cell-Derived Extracellular Vesicles Prevent Aristolochic Acid-Induced Kidney Fibrosis
Q92376668Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial-mesenchymal transition via the TGF-β/Smad signaling pathway
Q89170116Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation
Q46307085Mammalian MSC from selected species: Features and applications
Q64935938Matrix metalloproteinases in ureteropelvic junction obstruction.
Q61818598Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy
Q90311616Mesoporous Silica Nanoparticles Trigger Liver and Kidney Injury and Fibrosis Via Altering TLR4/NF-κB, JAK2/STAT3 and Nrf2/HO-1 Signaling in Rats
Q58712256Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury
Q89105506Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation
Q52339863STAT3, stem cells, cancer stem cells and p63.
Q90540850Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Q94657347The effect of intravenous human adipose-derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1), collagen type 1, and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats
Q49890380The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma
Q58115668The mechanisms and potential of stem cell therapy for penile fibrosis
Q92043634Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy

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