Targeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine

scientific article published on 27 September 2017

Targeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.21349
P932PMC publication ID5739621
P698PubMed publication ID29285234

P2093author name stringHongmei Zhu
Xiaoping Zhang
Dong Liu
Na Zhou
Yanxia Jiang
Xiaochun Zhang
Xiaonan Yang
Guifang Lu
Chuantao Zhang
Helei Hou
Zhaoyang Qian
Zhuokun Li
P2860cites workActivation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximabQ24600031
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Management of colorectal cancerQ26823550
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodiesQ27851465
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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancerQ27851787
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 studyQ27851971
Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivoQ27852093
The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysisQ27852988
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trialQ27853380
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Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencingQ34735416
Clinical Validation of Targeted Next Generation Sequencing for Colon and Lung CancersQ35772123
Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.Q36201032
Validation of targeted next-generation sequencing for RAS mutation detection in FFPE colorectal cancer tissues: comparison with Sanger sequencing and ARMS-Scorpion real-time PCR.Q36472281
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patientsQ36611365
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Profiling cancer gene mutations in clinical formalin-fixed, paraffin-embedded colorectal tumor specimens using targeted next-generation sequencingQ37698190
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On the Road to Precision Cancer Medicine: Analysis of Genomic Biomarker Actionability in 439 PatientsQ41102898
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.Q46034442
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Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients.Q48255185
K-ras mutations and cetuximab in colorectal cancerQ94852396
P433issue62
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
P304page(s)105072-105080
P577publication date2017-09-27
P1433published inOncotargetQ1573155
P1476titleTargeted next generation sequencing in Chinese colorectal cancer patients guided anti-EGFR treatment and facilitated precision cancer medicine
P478volume8

Reverse relations

Q92648935Concurrent TP53 mutations predict poor outcomes of EGFR-TKI treatments in Chinese patients with advanced NSCLCcites workP2860

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