MicroRNAs and cancer: Key paradigms in molecular therapy

scientific article published on 19 December 2017

MicroRNAs and cancer: Key paradigms in molecular therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2017.7638
P932PMC publication ID5778870
P698PubMed publication ID29434998

P2093author name stringWei Luo
Chang Gong
Shaohua Qu
Bodu Liu
Weige Tan
Gehao Liang
P2860cites workFrequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaQ24539231
Accumulation of miR-155 and BIC RNA in human B cell lymphomasQ24556523
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphomaQ24595213
Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem CellsQ24610880
Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221Q24631381
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Q24646996
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionQ24647373
Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cellsQ24649127
miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130Q24652820
Most mammalian mRNAs are conserved targets of microRNAsQ24655061
MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT)Q26853284
Origins and Mechanisms of miRNAs and siRNAsQ27860822
Serum miR-18a: a potential marker for hepatitis B virus-related hepatocellular carcinoma screeningQ45355708
Generation of miRNA sponge constructs.Q45800478
Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27.Q46876808
Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter.Q53289184
[miR-221 mediates epithelial-mesenchymal transition-related gene expressions via regulation of PTEN/Akt signaling in drug-resistant glioma cells].Q54373589
[Role of let-7 in maintaining characteristics of breast cancer stem cells].Q54492842
Angiogenesis is controlled by miR-27b associated with endothelial tip cellsQ58214716
Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjectsQ60191808
Construction of let-7a expression plasmid and its inhibitory effect on k-Ras protein in A549 lung cancer cellsQ82552350
Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting EzrinQ83961794
[Construction of miRNA sponge targeting miR-20a and stable expression in Jurkat leukemia cell line]Q85325542
MicroRNAs in cancerQ86065522
[Anti-leukemia mechanism of miR-17 and miR-20a silencing mediated by miRNA sponge]Q87598470
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Q27860849
Role of microRNAs in plant and animal developmentQ28188025
The role of let-7 in cell differentiation and cancerQ28259549
The roles of miR-17-92 cluster in mammal development and tumorigenesisQ28265498
miR-17-92 angiogenesis micromanagementQ28284891
Concomitant MYC and microRNA cluster miR-17-92 (C13orf25) amplification in human mantle cell lymphomaQ28290391
let-7 and miR-17-92: small-sized major players in lung cancer developmentQ28291431
microRNAs as oncogenes and tumor suppressorsQ29619907
Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancerQ31022382
Using expression profiling data to identify human microRNA targetsQ31137117
MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cellsQ33497932
Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancerQ33654179
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.Q33751351
SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast cancer cellsQ33891236
The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organismsQ34086807
Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.Q34159409
Chemical modification and design of anti-miRNA oligonucleotides.Q34200255
Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles.Q34205314
Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.Q34209735
Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?Q34455538
EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cellsQ34803710
Targeting miR-205 in breast cancerQ35008487
Placenta-specific miRNA (miR-512-3p) targets PPP3R1 encoding the calcineurin B regulatory subunit in BeWo cellsQ35045834
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.Q35606800
LNA-based oligonucleotide electrotransfer for miRNA inhibitionQ36142470
Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status iQ36250545
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progressionQ36498054
Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTENQ36656142
MicroRNA miR-30 family regulates non-attachment growth of breast cancer cellsQ36697933
MicroRNAs in metabolic diseaseQ37088373
Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancerQ37112360
Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27(kip1), p57(kip2), and PUMA.Q37278413
IL-6 upregulation contributes to the reduction of miR-26a expression in hepatocellular carcinoma cellsQ37371336
miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancerQ37375623
miR-21 as a key regulator of oncogenic processesQ37554678
miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1.Q39415867
P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells.Q39588893
Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cellsQ39601112
L-tyrosine-loaded nanoparticles increase the antitumoral activity of direct electric current in a metastatic melanoma cell modelQ39615037
Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells.Q39738230
miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2.Q39770962
MicroRNAs get to the heart of developmentQ42008926
Bifunctional oligodeoxynucleotide/antagomiR constructs: evaluation of a new tool for microRNA silencingQ42240544
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancerQ42263029
Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferationQ42705645
Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancerQ42928789
Reply: Comment on 'Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma'--β-blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugsQ42957826
PNA-based artificial nucleases as antisense and anti-miRNA oligonucleotide agentsQ43642144
miR-145 suppresses cell invasion in hepatocellular carcinoma cells: miR-145 targets ADAM17.Q44055579
miR-148b-nanoparticle conjugates for light mediated osteogenesis of human adipose stromal/stem cellsQ44309182
Functional microRNAs and target sites are created by lineage-specific transpositionQ37619287
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.Q37631219
Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinomaQ37650460
Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patientsQ37676792
miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartmentQ37706146
The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.Q37706322
Regulation of Myc by miR-34c: A mechanism to prevent genomic instability?Q37770207
Stem cell microRNAs in senescence and immortalization: novel players in cancer therapyQ37906461
MicroRNAs in learning, memory, and neurological diseasesQ38035830
High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancerQ38055600
Stem cell plasticity in development and cancer: epigenetic origin of cancer stem cellsQ38059676
A brief primer on microRNAs and their roles in angiogenesisQ38074494
Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAsQ38129926
Targeting angiogenesis and the tumor microenvironmentQ38135123
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implicationsQ38174308
MicroRNAs: master regulators of drug resistance, stemness, and metastasis.Q38186568
MicroRNAs in vascular aging and atherosclerosis.Q38200421
Strategies to antagonize miRNA functions in vitro and in vivoQ38285749
Design of a miRNA sponge for the miR-17 miRNA family as a therapeutic strategy against vulvar carcinoma.Q38841725
Downregulation of miR-101-3p by hepatitis B virus promotes proliferation and migration of hepatocellular carcinoma cells by targeting Rab5aQ38999469
MiR-324-5p inhibits proliferation of glioma by target regulation of GLI1.Q39007182
c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2.Q39007411
MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer.Q39010477
Effect of CDH1 gene methylation on transforming growth factor (TGF-β)-induced epithelial-mesenchymal transition in alveolar epithelial cell line A549.Q39016736
β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.Q39024860
The role of viral and host microRNAs in the Aujeszky's disease virus during the infection processQ39029366
Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanomaQ39039581
MiR-25 promotes gastric cancer cells growth and motility by targeting RECK.Q39090032
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like stateQ39176448
MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemiaQ39187984
MicroRNA let-7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K-Ras and HMGA2 gene expressionQ39248357
MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2.Q39298516
MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinomaQ39376558
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanismsQ39389208
miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancerQ39403567
P433issue3
P921main subjectmicroRNAQ310899
P304page(s)2735-2742
P577publication date2017-12-19
P1433published inOncology LettersQ20640514
P1476titleMicroRNAs and cancer: Key paradigms in molecular therapy
P478volume15

Reverse relations

cites work (P2860)
Q93059595Assessment of Circulating miRNA-17 and miRNA-222 Expression Profiles as Non-Invasive Biomarkers in Egyptian Patients with Non-Small-Cell Lung Cancer
Q96303080Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis
Q94552561Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor
Q64992388Functional Effects of let-7g Expression in Colon Cancer Metastasis.
Q90163228Gene Therapy in Cancer Treatment: Why Go Nano?
Q92861817Helicobacter pylori Dampens HLA-II Expression on Macrophages via the Up-Regulation of miRNAs Targeting CIITA
Q64997598High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer.
Q93108873Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer
Q64099500Involvement of miR-770-5p in trastuzumab response in HER2 positive breast cancer cells
Q92187262MiR-566 mediates cell migration and invasion in colon cancer cells by direct targeting of PSKH1
Q92798978MicroRNA 145 enhances chemosensitivity of glioblastoma stem cells to demethoxycurcumin
Q90079974MicroRNA Networks Modulate Oxidative Stress in Cancer
Q90706208MicroRNA-155-3p promotes glioma progression and temozolomide resistance by targeting Six1
Q90613540MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer
Q93005381Mining Featured Biomarkers Linked with Epithelial Ovarian CancerBased on Bioinformatics
Q91652631Overexpression of microRNA-145 inhibits tumorigenesis through autophagy in chemotherapy and radiation resistant neuroblastoma cells
Q64269751Prognostic significance of deregulated microRNAs in uveal melanomas
Q59133908Relevance of MicroRNAs as Potential Diagnostic and Prognostic Markers in Colorectal Cancer
Q59136865Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals
Q90568606The Regulatory Role of MicroRNAs in Breast Cancer
Q58797073Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1
Q92738337Upregulated microRNA‑671‑3p promotes tumor progression by suppressing forkhead box P2 expression in non‑small‑cell lung cancer
Q95261601miR-30a-3p inhibits renal cancer cell invasion and metastasis through targeting ATG12
Q93046978microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney

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