Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells

scientific article published on 11 January 2018

Downregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-18541-1
P932PMC publication ID5765044
P698PubMed publication ID29323151

P2093author name stringChenghai Li
Sihong Wang
Steven B Nicoll
Kristifor Sunderic
P2860cites workEffects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee jointQ80974239
Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritisQ81420634
Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritisQ46152792
OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitroQ46292130
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.Q48420309
Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling.Q50974876
Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells.Q50995238
Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cellsQ52232519
Elevated levels of 70,000 dalton heat shock protein in transiently thermotolerant Chinese hamster fibroblasts and in their stable heat resistant variants.Q54457919
Synthesis and degradation of heat shock proteins during development and decay of thermotolerance.Q54516614
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperonesQ59060241
Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cellsQ70332714
Expression and functional activity of heat shock proteins in human glioblastoma multiformeQ73621830
Osteogenic protein-1 promotes the synthesis and retention of extracellular matrix within bovine articular cartilage and chondrocyte culturesQ73691887
The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cellsQ77755017
The stimulation of bone growth by internal heatingQ78716896
Muscle temperature and sprint performance during soccer matches--beneficial effect of re-warm-up at half-timeQ80090612
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Chaperone machines for protein folding, unfolding and disaggregationQ27026110
Effectiveness of manual physical therapy and exercise in osteoarthritis of the knee. A randomized, controlled trialQ28143539
Periodic heat shock accelerated the chondrogenic differentiation of human mesenchymal stem cells in pellet cultureQ28540919
Constitutive expression of heat shock proteins Hsp90, Hsc70, Hsp70 and Hsp60 in neural and non-neural tissues of the rat during postnatal developmentQ28566038
Glutamine protects articular chondrocytes from heat stress and NO-induced apoptosis with HSP70 expressionQ33234033
Protein expression profiles during osteogenic differentiation of mesenchymal stem cells derived from human umbilical cord bloodQ33585097
Structure and function of aggrecanQ34122868
Regulation of osteoblast formation and functionQ34435661
Hsp and chaperone distribution during endochondral bone development in mouse embryoQ35086419
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.Q35170422
Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvariaQ36383313
The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.Q36838138
Genetic and molecular control of osterix in skeletal formationQ37051825
Human thermoregulation and measurement of body temperature in exercise and clinical settings.Q37156493
Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches.Q37830404
Death by chaperone: HSP90, HSP70 or both?Q39886887
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosisQ39943208
Human osteoblast-derived factors induce early osteogenic markers in human mesenchymal stem cells.Q39994432
Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesisQ40191875
BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathwaysQ40401314
Kinetics study of endogenous heat shock protein 70 expressionQ40585302
Differential effects of hyperthermia on macrophage interleukin-6 and tumor necrosis factor-alpha expressionQ40702135
Heat shock protein 70 is required for the survival of cancer cells.Q40825889
Adenovirus vector-mediated gene transduction to chondrocytes: in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction.Q41091309
Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiationQ42834807
Enhanced osteogenesis of human mesenchymal stem cells by periodic heat shock in self-assembling peptide hydrogelQ43201158
Expression of transduced HSP70 gene protects chondrocytes from stress.Q43541175
Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,.Q44560666
Core temperature responses and match running performance during intermittent-sprint exercise competition in warm conditions.Q45945355
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)553
P577publication date2018-01-11
P1433published inScientific ReportsQ2261792
P1476titleDownregulation of Heat Shock Protein 70 Impairs Osteogenic and Chondrogenic Differentiation in Human Mesenchymal Stem Cells
P478volume8

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cites work (P2860)
Q83225257Diversification of the heat shock response by Helitron transposable elements
Q92341194Identification of proteins that mediate the role of androgens in antler regeneration using label free proteomics in sika deer (Cervus nippon)
Q93367047Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy
Q91580809Proteomic characterization of early lung response to breast cancer metastasis in mice
Q64921821Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.

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