Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment.

scientific article

Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/978-3-319-67577-0_2
P932PMC publication ID6693322
P698PubMed publication ID29275462

P50authorJason L. WilliamsQ27955522
Thomas F. GajewskiQ88137719
P2093author name stringStefani Spranger
Brendan Horton
Leticia Corrales
Ayelet Sivan
P2860cites workLAG-3, a novel lymphocyte activation gene closely related to CD4Q24300309
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
Prevention of allogeneic fetal rejection by tryptophan catabolismQ24336018
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Type I interferon response and innate immune sensing of cancerQ27023235
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STINGQ27678540
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAAQ27679344
Type, density, and location of immune cells within human colorectal tumors predict clinical outcomeQ28131662
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cellsQ28248489
Type I interferon is selectively required by dendritic cells for immune rejection of tumorsQ28248500
The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunityQ28304923
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.Q40031362
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunityQ40944056
Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cellsQ42581359
Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapyQ44319954
Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanomaQ44443233
Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanomaQ44477273
Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancerQ44915586
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional toleranceQ47755230
Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy.Q50954469
Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.Q51023201
Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascitesQ56901877
Immunomodulatory actions of xanthenone anticancer agentsQ79895771
Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanomaQ84906858
Toll-like receptor control of the adaptive immune responsesQ29547305
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Nivolumab and ipilimumab versus ipilimumab in untreated melanomaQ29620657
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitmentQ30415355
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumorsQ30505678
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamideQ31144277
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironmentQ33606150
Effector memory T cells, early metastasis, and survival in colorectal cancerQ33992461
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.Q34153062
Activated STING in a vascular and pulmonary syndromeQ34241214
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acidQ34339243
Intrinsic self-DNA triggers inflammatory disease dependent on STING.Q34440680
FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancerQ34755205
Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammationQ35019491
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.Q35050169
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and ImmunityQ35634752
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpointsQ36160526
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responsesQ36380273
IRF5 gene polymorphisms in melanomaQ36380375
Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivoQ36409007
STING manifests self DNA-dependent inflammatory diseaseQ36436812
Molecular regulation of T-cell anergyQ36466372
Immune resistance orchestrated by the tumor microenvironmentQ36593747
Egr2-dependent gene expression profiling and ChIP-Seq reveal novel biologic targets in T cell anergyQ36823855
Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironmentQ36944380
Inflammation-driven carcinogenesis is mediated through STINGQ37207341
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.Q37502349
Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytesQ37570109
Gene signature in melanoma associated with clinical activity: a potential clue to unlock cancer immunotherapyQ37778702
Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanismsQ38058493
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironmentQ38949322
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alphaQ39635625
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)19-31
P577publication date2017-01-01
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleCancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment
P478volume1036

Reverse relations

cites work (P2860)
Q94526301A review of cancer immunotherapy: from the past, to the present, to the future
Q90677024Adaptive Immunity and the Tumor Microenvironment
Q90893993Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Q91736550Brain immunology and immunotherapy in brain tumours
Q97516973Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice
Q60917194EnanDIM - a novel family of L-nucleotide-protected TLR9 agonists for cancer immunotherapy
Q64227790HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles
Q60931630High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors
Q98665205Immunotherapy for advanced thyroid cancers - rationale, current advances and future strategies
Q91212056Interferons α and β in cancer: therapeutic opportunities from new insights
Q100416706Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer
Q90638466Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
Q92334561Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer
Q92586096Making cold malignant pleural effusions hot: driving novel immunotherapies
Q90212537Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes
Q92880920Procedural Requirements and Recommendations for Multiplex Immunofluorescence Tyramide Signal Amplification Assays to Support Translational Oncology Studies
Q64093111Proteoglycans and Immunobiology of Cancer-Therapeutic Implications
Q58087985Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again
Q91422883Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma
Q58119177Role of noninvasive molecular imaging in determining response
Q64971044STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models.
Q90677051Translational Biomarkers and Rationale Strategies to Overcome Resistance to Immune Checkpoint Inhibitors in Solid Tumors
Q57138281Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy
Q99552010Trial watch: STING agonists in cancer therapy
Q90733181WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
Q92136364Wnt Antagonists in Hematopoietic and Immune Cell Fate: Implications for Osteoporosis Therapies

Search more.