Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification.

scientific article published on 8 February 2018

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-20917-W
P932PMC publication ID5805758
P698PubMed publication ID29422515

P50authorLianjie MiaoQ87734093
Xueying TianQ87734095
Mingfu WuQ87734098
Bin ZhouQ59708703
A B FirulliQ68144966
P2093author name stringJun Li
Jingjing Li
Jiandong Liu
James F Martin
Hongbo Xin
Yangyang Lu
Saiyang Hu
David Shieh
Ryan Kanai
Bo-Yang Zhou
Harold Singer
P2860cites workHesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2Q24294772
Notch signaling is essential for ventricular chamber developmentQ24299001
Mutations in NOTCH1 cause aortic valve diseaseQ24307999
Tetralogy of fallot and other congenital heart defects in Hey2 mutant miceQ24310111
gridlock, an HLH gene required for assembly of the aorta in zebrafishQ28138188
Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene familyQ28138746
Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesisQ28140345
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decisionQ74211426
The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturationQ81387718
HEY2 mutations in malformed heartsQ81576274
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heartQ84735277
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populationsQ42114294
Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signalingQ42361373
Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardiumQ43081889
ErbB2 is essential in the prevention of dilated cardiomyopathy.Q43976647
Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system.Q44552654
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouseQ45005925
Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 geneQ48119789
Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart DevelopmentQ48318063
Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart.Q52099714
Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.Q52125445
Duplication of HEY2 in cardiac and neurologic development.Q53558945
HES and HERP families: multiple effectors of the Notch signaling pathwayQ28205103
Hesr, a mediator of the Notch signaling, functions in heart and vessel developmentQ28272434
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac deathQ28294931
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular systemQ28304868
CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expressionQ28505208
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of CortiQ28507372
p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardiumQ28507727
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunctionQ28507892
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptorQ28509287
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factorsQ28510928
HERP1 is a cell type-specific primary target of NotchQ28512071
BMP10 is essential for maintaining cardiac growth during murine cardiogenesisQ28586844
HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segmentsQ28587806
Multiple essential functions of neuregulin in developmentQ28587914
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationQ28589469
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivoQ28590848
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathwayQ28592687
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivoQ29620373
Asymmetric cell divisions promote stratification and differentiation of mammalian skinQ29620393
Epicardial spindle orientation controls cell entry into the myocardiumQ30495669
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiationQ30561780
CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membraneQ33745199
Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.Q33775170
Developmental patterning of the myocardiumQ33875810
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac functionQ34623997
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophyQ35787211
Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6.Q35993918
Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiationQ36108192
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart sizeQ36231054
Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional SpecificationQ36784413
Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow TractQ36831801
Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC)Q37051387
Sequential Notch activation regulates ventricular chamber developmentQ39752995
Identification of a hybrid myocardial zone in the mammalian heart after birth.Q41074479
Requirement for neuregulin receptor erbB2 in neural and cardiac developmentQ41269625
Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac developmentQ41639935
Helix-loop-helix factors in growth and differentiation of the vertebrate nervous systemQ41655734
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
P304page(s)2678
P577publication date2018-02-08
P1433published inScientific ReportsQ2261792
P1476titleNotch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification
P478volume8

Reverse relations

cites work (P2860)
Q89978033Brugada Syndrome: Oligogenic or Mendelian Disease?
Q91840194Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis
Q89606489Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors
Q52623886Mechanisms of Trabecular Formation and Specification During Cardiogenesis.
Q64117723Prediction of seed gene function in progressive diabetic neuropathy by a network-based inference method
Q60927424The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

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