GPCRS IN CONTEXT: SEXUAL DIMORPHISM IN THE CARDIOVASCULAR SYSTEM.

scientific article published on 16 February 2018

GPCRS IN CONTEXT: SEXUAL DIMORPHISM IN THE CARDIOVASCULAR SYSTEM. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.14160
P932PMC publication ID6177612
P698PubMed publication ID29451687

P50authorNicola J SmithQ57199403
P2093author name stringJames L J Coleman
Margaret A Mouat
P2860cites workCost-effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular riskQ45757541
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Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activationQ28579205
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Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGFQ29615227
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G protein-coupled prostanoid receptors and the kidneyQ31963761
Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanismQ32072303
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Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adultsQ33686561
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Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertensionQ33943987
Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axisQ34107645
Isolated human and rat cerebral arteries constrict to increases in flow: role of 20-HETE and TP receptorsQ34187177
The role of 20-HETE in androgen-mediated hypertensionQ34196923
Trends in the exploitation of novel drug targetsQ34205159
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstrictionQ34243343
Antidiuretic action of vasopressin: quantitative aspects and interaction between V1a and V2 receptor-mediated effectsQ34321476
2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor.Q37624176
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signalingQ37627060
Sex and gender differences in cardiovascular drug therapyQ38048668
Regulated expression of the prostacyclin receptor (IP) gene by androgens within the vasculature: Combined role for androgens and serum cholesterolQ38760544
The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells.Q38816699
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male MiceQ38833622
Anti-fibrotic actions of relaxin.Q38850557
Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke.Q39265589
Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysisQ39304495
Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapyQ39396429
Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB.Q39900531
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Altered pain perception and inflammatory response in mice lacking prostacyclin receptorQ40646776
Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differencesQ40730973
GPER is required for the age-dependent upregulation of the myocardial endothelin systemQ42359693
17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthaseQ42516727
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptorsQ42660449
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Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteriesQ43198450
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acidsQ43560259
Gender differences in the attenuation of salt-induced hypertension by angiotensin (1-7).Q43628577
Gender differences in vascular expression of endothelin and ET(A)/ET(B) receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertensionQ44130182
Sex differences in the antithrombotic effects of aspirinQ44208803
Gender differences in ET and NOS systems in ETB receptor-deficient rats: effect of a high salt dietQ44353803
Mechanisms of 17beta-estradiol on the production of ET-1 in ovariectomized ratsQ44588472
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COX-2-derived prostacyclin confers atheroprotection on female miceQ45154810
The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxationQ45216542
Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone.Q34385562
Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography–tandem mass spectrometryQ34419912
20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.Q34553783
A comprehensive view of sex-specific issues related to cardiovascular diseaseQ34577461
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptorsQ34581803
A common hypofunctional genetic variant of GPER is associated with increased blood pressure in womenQ34635603
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiolQ34787653
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female miceQ34849712
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat.Q34984856
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptorQ34999553
17 Beta-estradiol regulates the expression of endothelin receptor type B in the heartQ35045657
Sex differences in renal medullary endothelin receptor function in angiotensin II hypertensive ratsQ35120386
Androgens and cardiovascular diseaseQ35146318
Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis ratQ35216117
High salt diet increases the pressor response to stress in female, but not male ETB-receptor-deficient ratsQ35363150
Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.Q35447240
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivityQ35563456
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic ModulatorsQ35795751
Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis ratsQ35839121
Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skövde CohortQ35843056
GPER regulates endothelin-dependent vascular tone and intracellular calciumQ35968858
Gender differences in prostaglandin receptors of rat aortaQ36127980
ET-1 actions in the kidney: evidence for sex differencesQ36610325
G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity.Q36663052
The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and DiseaseQ36807388
Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertensionQ36877109
Endothelin, sex, and pregnancy: unique considerations for blood pressure control in femalesQ36902613
Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibitionQ37089449
Sex differences in angiotensin II- and aldosterone-induced hypertension: the central protective effects of estrogenQ37147084
Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD.Q37234714
Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats.Q37281123
Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER.Q37339848
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesityQ37435268
Physiology of endothelin and the kidneyQ37613679
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectsexual dimorphismQ181497
P304page(s)4047-4059
P577publication date2018-03-25
P1433published inBritish Journal of PharmacologyQ919631
P1476titleGPCRs in context: sexual dimorphism in the cardiovascular system
P478volume175

Reverse relations

cites work (P2860)
Q57279876Molecular pharmacology of GPCRs
Q52602004Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.
Q64954468Sex-Gender Variable: Methodological Recommendations for Increasing Scientific Value of Clinical Studies.

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