MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway

scientific article published on 18 January 2018

MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-017-0038-Z
P932PMC publication ID5833436
P698PubMed publication ID29348414

P50authorLi ZhangQ71036670
P2093author name stringZhifeng Wu
Yuhan Chen
Baoying Yuan
Zhaochong Zeng
Yinying Dong
P2860cites workFlagellin or lipopolysaccharide treatment modified macrophage populations after colorectal radiation of rats.Q51062887
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Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expressionQ73567260
Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblastsQ84504327
TLR4-dependent immune response promotes radiation-induced liver disease by changing the liver tissue interstitial microenvironment during liver cancer radiotherapyQ85994275
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesQ24670080
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Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytesQ28576416
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
TLR4 enhances TGF-beta signaling and hepatic fibrosisQ29620016
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.Q33938566
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesisQ34321742
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignanciesQ35022054
MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteinsQ35048883
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling PathwaysQ36376464
TNF receptor-associated factor 6 (TRAF6) mediates the angiotensin-induced non-canonical TGF-β pathway activation of c-kit(+) cardiac stem cellsQ36420224
MicroRNA-146 inhibits pro-inflammatory cytokine secretion through IL-1 receptor-associated kinase 1 in human gingival fibroblastsQ36863209
MicroRNA-146a-5p Negatively Regulates Pro-Inflammatory Cytokine Secretion and Cell Activation in Lipopolysaccharide Stimulated Human Hepatic Stellate Cells through Inhibition of Toll-Like Receptor 4 Signaling PathwaysQ37134499
Physiological and pathological roles for microRNAs in the immune systemQ37680666
The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases.Q37834316
Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of actionQ38012626
Stereotactic body radiotherapy: an effective local treatment modality for hepatocellular carcinomaQ38282463
Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunologyQ38311151
Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injuryQ38585912
Stimulation of hepatoma cell invasiveness and metastatic potential by proteins secreted from irradiated nonparenchymal cellsQ39379163
MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2.Q41082375
MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5aQ41834977
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitisQ41853585
A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury.Q42015640
TLR4-dependant immune response, but not hepatitis B virus reactivation, is important in radiation-induced liver disease of liver cancer radiotherapyQ42249102
Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cellsQ44782684
Isolation and culture of hepatic stellate cellsQ46666110
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectmicroRNAQ310899
P304page(s)22
P577publication date2018-01-18
P1433published inCell Death and DiseaseQ2197222
P1476titleMicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway
P478volume9

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