The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8.

scientific article published on 18 January 2018

The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1100461504
P356DOI10.1038/APS.2017.181
P932PMC publication ID6289376
P698PubMed publication ID29345254

P2093author name stringJian Ding
Yi-Xue Li
Ling-Hua Meng
Chen-Liang Guo
Jia-Jie Shi
Si-Meng Chen
P2860cites workInhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR.Q39401629
WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutantQ39696876
Mammalian Hsp22 is a heat-inducible small heat-shock protein with chaperone-like activityQ42214286
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activityQ43211411
Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO studyQ43503861
HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylationQ45292128
Prognosis of metastatic breast cancer subtypes: the hormone receptor/HER2-positive subtype is associated with the most favorable outcomeQ46782051
Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer.Q47184289
Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer.Q54354560
Phosphorylation of human small heat shock protein HspB8 (Hsp22) by ERK1 protein kinase.Q54593816
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Ras, PI(3)K and mTOR signalling controls tumour cell growthQ29614734
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CellMiner: a relational database and query tool for the NCI-60 cancer cell linesQ33472990
Mechanisms of tamoxifen resistanceQ34378877
High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.Q34549892
Overcoming endocrine resistance in metastatic breast cancer: Current evidence and future directions.Q34657786
Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphomaQ36287995
Endocrine resistance in breast cancer--An overview and updateQ36386322
Mechanisms of Endocrine Resistance in Breast CancerQ36851417
Tamoxifen resistance in breast cancerQ37224555
Understanding breast cancer - The long and winding roadQ37634220
Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitroQ37690245
Inhibiting 4EBP1 in glioblastoma.Q38659417
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LMTK3 is implicated in endocrine resistance via multiple signaling pathways.Q39301431
P433issue8
P921main subjecttamoxifenQ412178
P304page(s)1338-1346
P577publication date2018-01-18
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleThe mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8
P478volume39

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cites work (P2860)
Q90620381A low dose of AZD8055 enhances radiosensitivity of nasopharyngeal carcinoma cells by activating autophagy and apoptosis
Q91969134Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
Q64272437Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer