Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models.

scientific article published in January 2018

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3233/JAD-170617
P932PMC publication ID5988365
P698PubMed publication ID29439332

P50authorFabio Di DomenicoQ38804465
Shelby MeierQ59693208
Frederick A. SchmittQ64778804
Chiara LanzillottaQ87777117
P2093author name stringJose F Abisambra
Marzia Perluigi
Eugenio Barone
Antonella Tramutola
P2860cites workFunctional and morphological impact of ER stress on mitochondriaQ38102949
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Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's SyndromeQ38816807
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.Q41885676
Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degenerationQ44220290
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology.Q48513955
Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome.Q48731504
The unfolded protein response is activated in Alzheimer's disease.Q48839954
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Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivoQ83323941
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
ER stress-induced cell death mechanismsQ27027638
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumQ28509611
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.Q30367032
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Mongolism; a chromosomal disease (trisomy).Q33970057
Expression of heat shock proteins in Alzheimer's diseaseQ34091725
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Autophagy failure in Alzheimer's disease--locating the primary defectQ34987827
The neurology of Alzheimer disease in Down syndromeQ35417016
Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's diseaseQ36367840
Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanismQ36418920
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.Q36422268
Beta-amyloid, oxidative stress and down syndromeQ36683240
Activating transcription factor 4.Q36805075
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradationQ37069517
Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologyQ37102001
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic PhenotypeQ37141585
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampusQ37164517
Modelling Down syndromeQ37332055
Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapyQ37387412
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's diseaseQ37485744
Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.Q37613081
Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.Q37981067
P433issue1
P921main subjectDown syndromeQ47715
P304page(s)347-359
P577publication date2018-01-01
P1433published inJournal of Alzheimer's DiseaseQ6294755
P1476titleEarly and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models
P478volume62

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cites work (P2860)
Q92861486Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice
Q98177367Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
Q58609012Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

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