Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.

scientific article published on 7 February 2018

Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1700420
P932PMC publication ID5840022
P698PubMed publication ID29436413

P50authorDmitri I KotovQ57496207
Marc K. JenkinsQ38326121
P2093author name stringMichael F Goldberg
Jessica A Kotov
P2860cites workA novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Molecular and biological characterization of a murine ligand for CD40Q28186605
Control of Effector CD8 + T Cell Function by the Transcription Factor EomesoderminQ28589387
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteinsQ29547534
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cellsQ29622847
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humansQ30412301
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infectionQ30413410
T follicular helper cell dynamics in germinal centersQ30573316
Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cellsQ33566339
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hostsQ33730171
Fast on-rates allow short dwell time ligands to activate T cellsQ33928549
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza InfectionQ39056737
Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathwaysQ39378312
M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cellsQ39516970
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cellsQ40757721
Elevated temperature regulates tumor necrosis factor-mediated immune killingQ40771367
HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcomeQ41937295
Antigen-specific activation of effector macrophages by IFN-gamma producing (TH1) T cell clones. Failure of IL-4-producing (TH2) T cell clones to activate effector function in macrophages.Q45111834
CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.Q45756742
Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis.Q46496395
Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signalsQ46854587
Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.Q46863693
Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infectionQ49021488
Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.Q54177718
How the T Cell Repertoire Becomes Peptide and MHC SpecificQ56922033
BAFF and LPS cooperate to induce B cells to become susceptible to CD95/Fas-mediated cell deathQ56964164
Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicityQ71608561
Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levelsQ72231618
Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicityQ74595850
Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritisQ78505434
CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punchQ80142432
Cutting edge: MHC class II-restricted killing in vivo during viral infectionQ81235500
Identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosisQ34004633
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cellsQ34170759
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patternsQ34507271
High efficiency of antiviral CD4(+) killer T cellsQ34658438
Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68Q35164112
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cellsQ35197906
Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.Q35525803
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunityQ35701686
STAT5 is a potent negative regulator of TFH cell differentiationQ35761809
Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific mannerQ36007588
Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infectionQ36056478
Vaccination Produces CD4 T Cells with a Novel CD154-CD40-Dependent Cytolytic MechanismQ36075279
Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium.Q36126324
Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infectionQ36239323
TCR/CD3 coupling to Fas-based cytotoxicityQ36364437
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.Q36383089
An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitroQ36433369
Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine ProtectionQ36434178
Tracking epitope-specific T cells.Q36454999
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.Q36455294
Vaccination against persistent viral infection exacerbates CD4+ T-cell-mediated immunopathological diseaseQ36549146
Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytesQ36635015
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infectionQ36637922
Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of EomesoderminQ36750028
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunityQ36955782
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responsesQ37029283
Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Q37155667
Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection.Q37179446
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunityQ37245044
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvantQ37273249
Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virusQ37412380
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)2004-2012
P577publication date2018-02-07
P1433published inJournal of ImmunologyQ3521441
P1476titleMany Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential
P478volume200

Reverse relations

cites work (P2860)
Q59358622Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection
Q90467644IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy
Q91606299Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells
Q99237747Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity

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