Design of cyclic and d-amino acids containing peptidomimetics for inhibition of protein-protein interactions of HER2-HER3.

scientific article published in February 2018

Design of cyclic and d-amino acids containing peptidomimetics for inhibition of protein-protein interactions of HER2-HER3. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PSC.3066
P932PMC publication ID6284401
P698PubMed publication ID29436155

P50authorSitanshu SinghQ87770080
Seetharama D JoisQ87770082
P2093author name stringRushikesh Sable
Ted Gauthier
Sandeep Pallerla
Himgauri Naik
P2860cites workHumanization of an anti-p185HER2 antibody for human cancer therapyQ24561842
Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor ReceptorQ27664452
Cancer statistics, 2013Q27860762
Untangling the ErbB signalling networkQ27860884
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptorsQ28207289
Anatomy of hot spots in protein interfacesQ29616238
The third dimension bridges the gap between cell culture and live tissueQ29616642
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
ERBB receptors and cancer: the complexity of targeted inhibitorsQ29619520
Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signallingQ33539281
Design, synthesis, and docking studies of peptidomimetics based on HER2-herceptin binding site with potential antiproliferative activity against breast cancer cell linesQ33835904
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingQ33886341
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironmentQ34111958
Development of Herceptin resistance in breast cancer cellsQ34293506
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancerQ35177848
Structure-activity relationship of conformationally constrained peptidomimetics for antiproliferative activity in HER2-overexpressing breast cancer cell linesQ35185574
Drug resistance and the microenvironment: nature and nurtureQ35214616
Methotrexate (MTX)-cIBR conjugate for targeting MTX to leukocytes: conjugate stability and in vivo efficacy in suppressing rheumatoid arthritisQ35759924
Herceptin: mechanisms of action and resistanceQ36386680
Inhibition of protein-protein interaction of HER2-EGFR and HER2-HER3 by a rationally designed peptidomimeticQ36610755
Combining mTOR Inhibitors with Chemotherapy and Other Targeted Therapies in Advanced Breast Cancer: Rationale, Clinical Experience, and Future DirectionsQ36629854
Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer.Q36710542
Hot spots--a review of the protein-protein interface determinant amino-acid residuesQ36839286
The effect of HER2 expression on cisplatin-based chemotherapy in advanced non-small cell lung cancer patients.Q37278752
Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancerQ37579647
Synthetic therapeutic peptides: science and marketQ37625355
The safety and side effects of monoclonal antibodiesQ37715703
Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.Q37721805
EGFR-directed monoclonal antibodies in non-small cell lung cancerQ38072670
Plasma protein binding: from discovery to developmentQ38116840
Early engineering approaches to improve peptide developability and manufacturabilityQ38262021
Protein detection using proximity-dependent DNA ligation assays.Q38289736
Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitorsQ39004424
Activity of anticancer agents in a three-dimensional cell culture modelQ39675257
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyQ39960692
Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.Q40294145
Distinctive alterations of invasiveness, drug resistance and cell-cell organization in 3D-cultures of MCF-7, a human breast cancer cell line, and its multidrug resistant variantQ40737038
The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicityQ41566049
Specificity within the EGF family/ErbB receptor family signaling networkQ41721612
Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.Q42489992
Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants: optimization and in vitro characterizationQ42565516
A peptidomimetic with a chiral switch is an inhibitor of epidermal growth factor receptor heterodimerization.Q44114723
Update on in vitro cytotoxicity assays for drug developmentQ44748416
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.Q46004116
Designed peptides with homochiral and heterochiral diproline templates as conformational constraintsQ46586571
Crystal structures of peptide enantiomers and racemates: probing conformational diversity in heterochiral Pro-Pro sequences.Q46706616
Comprehensive determination of the cyclic FEE peptide chemical stability in solution.Q54570477
Tech.Sight. Analyzing biomolecular interactionsQ77768954
Serum stability of peptidesQ81826448
P433issue2
P921main subjectprotein designQ410814
protein-protein interactionQ896177
P577publication date2018-02-01
P1433published inJournal of Peptide ScienceQ3186932
P1476titleDesign of cyclic and d-amino acids containing peptidomimetics for inhibition of protein-protein interactions of HER2-HER3
P478volume24

Reverse relations

Q90231367d-amino Acids in Health and Disease: A Focus on Cancercites workP2860

Search more.