Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer.

scientific article published on 6 February 2018

Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00018-018-2755-6
P698PubMed publication ID29411041

P50authorXiaohua JiangQ79346056
P2093author name stringYan Wang
Hsiao Chang Chan
Jieting Zhang
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Down-regulated CFTR During Aging Contributes to Benign Prostatic HyperplasiaQ28575323
Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2Q28578305
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TGF-beta 1 downregulates CFTR expression and function in nasal polyps of non-CF patientsQ80551100
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Amplification of FSH signaling by CFTR and nuclear soluble adenylyl cyclase in the ovaryQ39201838
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CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancerQ39314424
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Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosisQ39390028
CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammationQ39474714
Promoter hypermethylation of the CFTR gene and clinical/pathological features associated with non-small cell lung cancer.Q39541029
Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signallingQ39678214
CFTR and tight junctions in cultured bronchial epithelial cells.Q39789180
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosisQ40006173
Frequency of carriers of cystic fibrosis gene among patients with myeloid malignancy and melanomaQ40096774
Lower Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Promotes the Proliferation and Migration of Endometrial Carcinoma.Q37677195
TGF-β1 promotes colorectal cancer immune escape by elevating B7-H3 and B7-H4 via the miR-155/miR-143 axisQ37687142
CFTR is a potential marker for nasopharyngeal carcinoma prognosis and metastasisQ37718318
Regulation and roles of bicarbonate transporters in cancerQ37719006
MicroRNAs and their target gene networks in renal cell carcinomaQ37828237
MicroRNAs and cystic fibrosis--an epigenetic perspective.Q37863190
Estrogen dependent signaling in reproductive tissues - a role for estrogen receptors and estrogen related receptorsQ37941428
Cell polarity proteins and cancer.Q37998815
MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanismsQ40262856
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Functional and molecular characterization of a volume-activated chloride channel in rabbit corneal epithelial cells.Q40474037
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosisQ40488178
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Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cellsQ40598336
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATPQ40794305
CFTR deltaF508 carrier status, risk of breast cancer before the age of 40 and histological grading in a population-based case-control studyQ41004860
CFTR is a mechanosensitive anion channel: a real stretch?Q41118255
Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smokeQ41178546
CFTR as a cAMP-dependent regulator of sodium channelsQ41312779
Estrogen-dependent expression of the cystic fibrosis transmembrane regulator gene in a novel uterine epithelial cell line.Q41446679
Molecular Structure of the Human CFTR Ion Channel.Q41598483
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance RegulatorQ41599873
Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migrationQ42130797
Defective CFTR-regulated granulosa cell proliferation in polycystic ovarian syndromeQ42472394
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationshipQ42809539
Cystic fibrosis transmembrane regulator gene carrier status is a risk factor for young onset pancreatic adenocarcinomaQ43004128
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Effect of phenol red and steroid hormones on cystic fibrosis transmembrane conductance regulator in mouse endometrial epithelial cellsQ43758615
Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayersQ43906839
Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of spermQ44600125
Cancer risk and PCOS.Q44771365
Bicarbonate secretion: it takes two to tangoQ44824846
Constitutive activation of nuclear factor κB contributes to cystic fibrosis transmembrane conductance regulator expression and promotes human cervical cancer progression and poor prognosisQ45239383
Elevated levels of miR-145 correlate with SMAD3 down-regulation in cystic fibrosis patients.Q45803588
A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancerQ45873847
The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity.Q45923491
Physiological basis of cystic fibrosis: a historical perspectiveQ46380953
miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-β signaling pathwayQ48177139
CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic developmentQ48232238
Bacterial overgrowth, dysbiosis, inflammation, and dysmotility in the Cystic Fibrosis intestineQ49551226
Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancerQ50171485
Clinical and morphological characteristics of sporadic genetically determined pancreatitis as compared to idiopathic pancreatitis: higher risk of pancreatic cancer in CFTR variants.Q50921436
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Exaggerated apoptosis and NF-kappaB activation in pancreatic and tracheal cystic fibrosis cells.Q51022821
Mouse microRNA-23b regulates expression of Hes1 gene in P19 cells.Q51097380
Early colon screening of adult patients with cystic fibrosis reveals high incidence of adenomatous colon polyps.Q51182247
[Whole Genome Expression Profiling Analysis of Metastasis and Drug-resistance-related Genes in Epithelial Ovarian Cancer Cells].Q51472916
The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer.Q51650974
CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents.Q52227548
Weighted gene co-expression network analysis of pneumocytes under exposure to a carcinogenic dose of chloroprene.Q52883103
Cystic fibrosis of the pancreas. A generalised disturbance of water and electrolyte movement in exocrine tissues.Q54377227
Methylation of multiple genes as molecular markers for diagnosis of a small, well-differentiated hepatocellular carcinoma.Q54485840
Cancer Risk in Nontransplanted and Transplanted Cystic Fibrosis Patients: A 10-Year StudyQ56779668
The Risk of Cancer among Patients with Cystic FibrosisQ56779992
Cancer risk among patients with cystic fibrosis and their first-degree relativesQ57697731
Blockers of volume-activated Cl? currents inhibit endothelial cell proliferationQ62661291
Cystic fibrosis hetero- and homozygosity is associated with inhibition of breast cancer growthQ71046595
Stimulation of the cystic fibrosis transmembrane regulator expression by estrogen in vivoQ72089887
The cystic fibrosis delta F508 gene mutation and cancerQ73509772
F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patientsQ73806208
Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxiaQ73847876
Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tractQ77759146
Glibenclamide induces apoptosis through inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and intracellular Ca(2+) release in HepG2 human hepatoblastoma cellsQ78109574
The phenotypic consequences of CFTR mutationsQ35206694
Analysis of CFTR interactome in the macromolecular complexesQ35228705
Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTRQ35434553
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulatorQ35438966
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility.Q35834494
Association of CFTR gene polymorphisms with papillary thyroid cancerQ35995455
Mechanisms of bicarbonate secretion in the pancreatic ductQ36041035
Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinomaQ36076351
Overexpression of Plasminogen Activator Inhibitor-1 in Advanced Gastric Cancer with Aggressive Lymph Node MetastasisQ36186928
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.Q36263013
The Enigmatic Gut in Cystic Fibrosis: Linking Inflammation, Dysbiosis, and the Increased Risk of MalignancyQ36268539
CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo developmentQ36294566
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.Q36312671
CFTR-France, a national relational patient database for sharing genetic and phenotypic data associated with rare CFTR variants.Q36398902
Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epitheliumQ36480411
The CFTR ion channel: gating, regulation, and anion permeationQ36488258
The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartmentQ36594740
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposureQ36673189
Testicular cancer and cryptorchidismQ36700205
Genomic landscape of non-small cell lung cancer in smokers and never-smokersQ36851245
Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalitiesQ36865792
Role of oxygen availability in CFTR expression and functionQ36951832
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epitheliumQ37061658
Cigarette smoke and CFTR: implications in the pathogenesis of COPDQ37234904
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretionQ37328491
Transcriptional regulation of cell polarity in EMT and cancerQ37333606
Polarity proteins in migration and invasionQ37333610
MARCH2 regulates autophagy by promoting CFTR ubiquitination and degradation and PIK3CA-AKT-MTOR signalingQ37371610
EMT, the cytoskeleton, and cancer cell invasionQ37377630
Role of CFTR in epithelial physiology.Q37553595
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator functionQ37572359
Weighted gene co-expression network analysis in identification of metastasis-related genes of lung squamous cell carcinoma based on the Cancer Genome Atlas databaseQ37636947
Defective CFTR- β-catenin interaction promotes NF-κB nuclear translocation and intestinal inflammation in cystic fibrosisQ37665560
Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in TumorsQ30985593
Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese populationQ31058055
Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cellsQ31948359
Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammationQ33208286
Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretionQ33348947
Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D MutationQ33551857
Tissue and cellular expression patterns of porcine CFTR: similarities to and differences from human CFTRQ33586056
Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinomaQ33596314
Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8Q33808094
Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines.Q33818738
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancerQ33844906
Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patientsQ33869132
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.Q33899411
A PDZ-interacting domain in CFTR is an apical membrane polarization signalQ33902133
Hypoxia regulates gene expression of alveolar epithelial transport proteinsQ33910362
Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer riskQ33952622
Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosisQ34023921
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.Q34162541
A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosisQ34206913
Factors associated with Type I and Type II endometrial cancerQ34233057
Regulation of male fertility by CFTR and implications in male infertility.Q34282487
Use of kinase inhibitors to correct ΔF508-CFTR functionQ34304720
CFTR: interacting with everything?Q34322998
CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway.Q34339107
Epithelial ovarian cancer risk among women with polycystic ovary syndromeQ34400660
Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysisQ34537405
Differential Gene Expression Landscape of Co-Existing Cervical Pre-Cancer Lesions Using RNA-seqQ34574451
A cytokine-mediated link between innate immunity, inflammation, and cancerQ34625152
Tight Junction–Associated Signaling Pathways Modulate Cell Proliferation in Uveal MelanomaQ34646857
Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motifQ34811102
The NF-kappaB signaling in cystic fibrosis lung disease: pathophysiology and therapeutic potentialQ35043484
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammationQ35073075
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosisQ35121200
Regulation of TGF-beta signaling and its roles in progression of tumorsQ35161752
P433issue10
P921main subjectcystic fibrosisQ178194
transmembrane proteinQ424204
P304page(s)1737-1756
P577publication date2018-02-06
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleCystic fibrosis transmembrane conductance regulator-emerging regulator of cancer
P478volume75

Reverse relations

cites work (P2860)
Q90394856Epigenetic Modification of CFTR in Head and Neck Cancer
Q90387464The future of cystic fibrosis care: a global perspective

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