Impact of oncogenic pathways on evasion of antitumour immune responses.

scientific article published on 12 January 2018

Impact of oncogenic pathways on evasion of antitumour immune responses. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NRC.2017.117
P932PMC publication ID6685071
P698PubMed publication ID29326431

P2093author name stringStefani Spranger
Thomas F Gajewski
P2860cites workSafety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosisQ24658222
Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccineQ26748727
MYC, Metabolism, and CancerQ26783555
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cellsQ28248489
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cellsQ28591976
NF-kappaB functions as a tumour promoter in inflammation-associated cancerQ29614598
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerQ29614599
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated MelanomaQ29615443
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in miceQ29615615
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
MYC on the path to cancerQ29619979
PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
LKB1 modulates lung cancer differentiation and metastasisQ30080027
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitmentQ30415355
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironmentQ33606150
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumorsQ33765767
CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene InactivationQ34346803
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced MelanomaQ34478015
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapyQ34522172
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.Q34557699
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunityQ34625640
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomasQ35008028
Cross-presentation of tumor associated antigens through tumor-derived autophagosomesQ35084414
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomasQ35621787
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and ImmunityQ35634752
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.Q35737352
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacyQ35833912
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiotaQ35833921
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationQ35928960
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.Q36134167
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpointsQ36160526
The consensus molecular subtypes of colorectal cancerQ36258187
Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.Q36553576
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progressionQ36637905
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapyQ36653748
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic MelanomaQ36730827
Molecular and genetic properties of tumors associated with local immune cytolytic activityQ36869059
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effectsQ37077185
NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cellsQ37191112
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cellsQ37194949
Mutations Associated with Acquired Resistance to PD-1 Blockade in MelanomaQ37222679
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinomaQ37428076
Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanomaQ37473978
Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumorsQ37474092
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.Q37502349
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomasQ37730613
Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancerQ37995693
STAT3 activation: A key factor in tumor immunoescapeQ38140901
Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell TherapyQ38704192
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.Q38709131
STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.Q38731119
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 TherapyQ38743794
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.Q38776860
Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironmentQ38779257
MYC regulates the antitumor immune response through CD47 and PD-L1Q38787131
Primary, Adaptive, and Acquired Resistance to Cancer ImmunotherapyQ39130451
Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.Q39338105
Clinical Response of a Patient to Anti-PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell TumorsQ39379480
Braf(V600E) cooperates with Pten loss to induce metastatic melanomaQ39873596
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.Q40050674
Baseline β-catenin, programmed death-ligand 1 expression and tumour-infiltrating lymphocytes predict response and poor prognosis in BRAF inhibitor-treated melanoma patientsQ40241105
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cellsQ40602668
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite InstabilityQ40850728
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunityQ40944056
Claudin-low bladder tumors are immune infiltrated and actively immune suppressedQ41160701
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.Q41571576
Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder CancerQ42176800
Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epitheliaQ42521880
Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder CancerQ47782346
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.Q47962756
PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 ResponsesQ48008350
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.Q48173597
The spectrum of T cell metabolism in health and diseaseQ49853005
An immune-active tumor microenvironment favors clinical response to ipilimumabQ56898024
Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision ImmunotherapyQ56965582
Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor ImmunityQ63884125
Sustained loss of a neoplastic phenotype by brief inactivation of MYCQ74413944
On the TRAIL toward death receptor-based cancer therapeuticsQ80117652
Characterization of melanocyte-specific inducible Cre recombinase transgenic miceQ83290390
Targeting neoantigens to augment antitumour immunityQ88839268
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)139-147
P577publication date2018-01-12
P1433published inNature Reviews CancerQ641657
P1476titleImpact of oncogenic pathways on evasion of antitumour immune responses
P478volume18

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cites work (P2860)
Q92072042Allies or Enemies-The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment
Q90142120Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma
Q58104267Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects
Q91658442BCG Therapy of Bladder Cancer Stimulates a Prolonged Release of the Chemoattractant CXCL10 (IP10) in Patient Urine
Q89206309Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition
Q60919588Bioactive Nanoparticles for Cancer Immunotherapy
Q92310063Cancer Vaccines: Steering T Cells Down the Right Path to Eradicate Tumors
Q93162228Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Q90690121Characterization of human cancer xenografts in humanized mice
Q89793689Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
Q99551100Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer
Q59798138Clinical utility of tumor mutational burden in patients with non-small cell lung cancer treated with immunotherapy
Q92578527Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Q101226463De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors
Q89944648Determinants of Resistance to Checkpoint Inhibitors
Q60947640Dissecting the Immune Landscape of Acute Myeloid Leukemia
Q92723030Distinct signatures of lung cancer types: aberrant mucin O-glycosylation and compromised immune response
Q91942447Dual Pro- and Anti-Inflammatory Features of Monocyte-Derived Dendritic Cells
Q90669058Epigenetic Mechanisms Dictating Eradication of Cancer by Natural Killer Cells
Q90482442Exercise Training in Cancer Control and Treatment
Q93043610Firing Up Cold Tumors
Q92014001Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models
Q98183420Genetic and epigenetic regulation of cancer coagulome - lessons from heterogeneity of cancer cell populations
Q98906809Genome-wide identification of differentially methylated promoters and enhancers associated with response to anti-PD-1 therapy in non-small cell lung cancer
Q92179996Genomic correlates of response to immune checkpoint blockade
Q64086837Harnessing immunotherapy for liver recipients with hepatocellular carcinoma: a review from a transplant oncology perspective
Q92341987Host tissue determinants of tumour immunity
Q90569691Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade
Q90628298Identification of Antigenic Targets
Q57791813Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations
Q97528619Immune checkpoint inhibitors in women with gynecologic cancers: Practical considerations
Q52804400Immunobiology of Solid Cancers: Cellular and Molecular Pathways as Potential Diagnostic and Therapeutic Targets.
Q94452370Immunomodulation by anticancer cell cycle inhibitors
Q58550797Immunotherapy failure in adrenocortical cancer: where next?
Q93162619Improving cancer immunotherapy through nanotechnology
Q104135062Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
Q64883630Integrating the DNA damage and protein stress responses during cancer development and treatment.
Q100992474Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells
Q89620002Leukobiopsy - A Possible New Liquid Biopsy Platform for Detecting Oncogenic Mutations
Q104745191Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
Q92586096Making cold malignant pleural effusions hot: driving novel immunotherapies
Q56886821Mechanisms of Resistance to Immune Checkpoint Blockade
Q100737293Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state
Q64095218Molecular Drivers of Potential Immunotherapy Failure in Adrenocortical Carcinoma
Q57818011Multi-Omics Profiling of the Tumor Microenvironment: Paving the Way to Precision Immuno-Oncology
Q57395724Natural killer cells and other innate lymphoid cells in cancer
Q90349565Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis
Q98776115Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy
Q92334728Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy
Q92094127Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells
Q92541764Ping-Pong-Tumor and Host in Pancreatic Cancer Progression
Q63246478Potential Therapies for Infectious Diseases Based on Targeting Immune Evasion Mechanisms That Pathogens Have in Common With Cancer Cells
Q58769285Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification
Q90568070Prognostic Factors and Biomarkers of Responses to Immune Checkpoint Inhibitors in Lung Cancer
Q56888903RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade
Q91297827Regulatory T cells in cancer immunosuppression - implications for anticancer therapy
Q91422883Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma
Q97520423Resistance to immune checkpoint inhibitors in non-small cell lung cancer: biomarkers and therapeutic strategies
Q57296955Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity
Q64946390Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression.
Q54213148Sequential immunotherapy in a patient with primary refractory Hodgkin lymphoma and novel mutations.
Q92245345T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance
Q92350765Tankyrase inhibition sensitizes cells to CDK4 blockade
Q93216930Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Q91974682Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment
Q98166041Targeting regulatory T cells for improving cancer therapy: Challenges and prospects
Q90677037The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier
Q54122937The Role of mTOR in Neuroendocrine Tumors: Future Cornerstone of a Winning Strategy?
Q92083224The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System
Q90242165The emerging role of epigenetic therapeutics in immuno-oncology
Q90372098The lung microenvironment: an important regulator of tumour growth and metastasis
Q97525228Toward Systems Biomarkers of Response to Immune Checkpoint Blockers
Q90265999Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology
Q92511116Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2)
Q89454298Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells
Q92173942Tumour microenvironment of pancreatic cancer: immune landscape is dictated by molecular and histopathological features
Q90391286Tumour-intrinsic resistance to immune checkpoint blockade
Q96945876Turning Cold into Hot: Firing up the Tumor Microenvironment
Q62766311Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
Q56888915WNT Signaling in Cancer Immunosurveillance
Q92538517WNT Signaling in Tumors: The Way to Evade Drugs and Immunity
Q90733181WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment
Q64104154Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
Q98281070Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer
Q64893136m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Q99558042β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancer

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