N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease

scientific article published on 10 January 2018

N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-18567-5
P932PMC publication ID5762728
P698PubMed publication ID29321566

P50authorSergey KozinQ57418276
Maria ZharkovaQ61130823
Igor A. PopovQ64545153
P2093author name stringAlexey B Mantsyzov
Eugene N Nikolaev
Elena V Kugaevskaya
Nina I Solovyeva
Alexander A Makarov
Alexander V Veselovsky
Maria I Indeykina
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The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser [...]Q33310715
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Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer diseaseQ57278129
Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's diseaseQ57721654
ESI-MS identification of the minimal zinc-binding center in natural isoforms of β-amyloid domain 1–16Q57721717
Capabilities of MS for Analytical Quantitative Determination of the Ratio of α- and βAsp7 Isoforms of the Amyloid-β Peptide in Binary MixturesQ57721733
Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble ComplexQ57721764
Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathyQ58477361
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)298
P577publication date2018-01-10
P1433published inScientific ReportsQ2261792
P1476titleN-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease
P478volume8

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cites work (P2860)
Q64091575Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease
Q57721642Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's Disease
Q89876372Using human genetics to guide the repurposing of medicines

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