Exercise intolerance in type 2 diabetes: is there a cardiovascular contribution?

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Exercise intolerance in type 2 diabetes: is there a cardiovascular contribution? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/JAPPLPHYSIOL.00070.2017
P932PMC publication ID6008073
P698PubMed publication ID29420147

P50authorMichael E TschakovskyQ87729142
P2093author name stringVeronica J Poitras
Robert W Hudson
P2860cites workPeroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulatorQ24294798
Erythrocytes: oxygen sensors and modulators of vascular toneQ24653317
Relationship between myocardial perfusion and dysfunction in diabetic cardiomyopathy: a study of quantitative contrast echocardiography and strain rate imagingQ24676053
Oxygen transport and peripheral microcirculation in long-term diabetesQ68175571
Splanchnic and muscle metabolism during exercise in NIDDM patientsQ71776010
Muscle fiber composition and capillary density in women and men with NIDDMQ72133555
Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetesQ73095390
Lipid oxidation is reduced in obese human skeletal muscleQ73127280
Heightened norepinephrine-mediated vasoconstriction in type 2 diabetesQ73277050
Effects of systemic arterial blood pressure on the contractile force of a human hand muscleQ73630962
Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitusQ74761277
Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humansQ77520231
Oxygen deficit and repayment in exerciseQ78992809
Effects of Type II diabetes on muscle microvascular oxygen pressuresQ79172907
Effect of arterial oxygenation on quadriceps fatigability during isolated muscle exerciseQ79378102
Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP releaseQ79386804
Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003Q79678535
Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopyQ80012526
Diagnosis and classification of diabetes mellitusQ80423340
Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetesQ80736217
The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcersQ81053338
Control of microvascular oxygen pressures in rat muscles comprised of different fibre typesQ81239972
Effects of arterial oxygen content on peripheral locomotor muscle fatigueQ82646756
Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during submaximal cycling exerciseQ82995925
Women with type 2 diabetes perceive harder effort during exercise than nondiabetic womenQ84947236
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1Q24679555
BDNF mediates adaptive brain and body responses to energetic challengesQ27693260
Hemoglobin and the paracrine and endocrine functions of nitric oxideQ28190068
The prevalence of comorbid depression in adults with diabetes: a meta-analysisQ28190708
Blood lactate measurements and analysis during exercise: a guide for cliniciansQ28263445
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Psychophysical bases of perceived exertionQ29615667
Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise trainingQ30430704
Abnormal skeletal muscle capillary recruitment during exercise in patients with type 2 diabetes mellitus and microvascular complicationsQ30435895
Plasma nitrite response and arterial reactivity differentiate vascular health and performanceQ30436021
Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathyQ30980109
Exogenous NO administration and alpha-adrenergic vasoconstriction in human limbsQ33188181
Continuous, non-invasive measurement of the haemodynamic response to submaximal exercise in patients with diabetes mellitus: evidence of impaired cardiac reserve and peripheral vascular response.Q33511919
Attenuated purinergic receptor function in patients with type 2 diabetesQ33556510
Interaction of factors determining oxygen uptake at the onset of exercise.Q33588866
An enzymatic approach to lactate production in human skeletal muscle during exerciseQ33897316
Endothelial dysfunction in diabetes.Q33959485
Cardiac dysfunction during exercise in uncomplicated type 2 diabetes.Q33991343
Effects of Type II diabetes on exercising skeletal muscle blood flow in the ratQ34305268
Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexesQ34311069
Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in ratsQ34345115
Limits to sustainable muscle performance: interaction between glycolysis and oxidative phosphorylationQ34387948
Functional sympatholysis during exercise in patients with type 2 diabetes with intact response to acetylcholineQ35043742
Limits to the measurement of habitual physical activity by questionnairesQ35143423
Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific mannerQ35159853
Barriers to physical activity in patients with diabetesQ35519380
Peripheral microvascular response to muscle contraction is unaltered by early diabetes but decreases with age.Q35562053
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscleQ35676919
Cellular mechanisms of skeletal muscle fatigue.Q35751506
Tests of glycemia in diabetesQ35818970
Impaired cerebral blood flow and oxygenation during exercise in type 2 diabetic patientsQ35877567
Physical activity/exercise and type 2 diabetesQ35903410
Independent effect of type 2 diabetes beyond characteristic comorbidities and medications on immediate but not continued knee extensor exercise hyperemiaQ35921779
Lack of independent effect of type 2 diabetes beyond characteristic comorbidities and medications on small muscle mass exercising muscle blood flow and exercise toleranceQ36036454
Abnormal left ventricular longitudinal functional reserve in patients with diabetes mellitus: implication for detecting subclinical myocardial dysfunction using exercise tissue Doppler echocardiography.Q36172988
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes.Q48345277
Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exerciseQ50439062
Hemodynamic responses during graded and constant-load plantar flexion exercise in middle-aged men and women with type 2 diabetesQ50451228
Similar level of impairment in exercise performance and oxygen uptake kinetics in middle-aged men and women with type 2 diabetes.Q50498283
Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise.Q50528010
Effects of Type II diabetes on capillary hemodynamics in skeletal muscle.Q50728365
Effects of non-insulin-dependent diabetes on oxygen consumption during treadmill exercise.Q51588171
Reduced exercise arteriovenous O2 difference in Type 2 diabetesQ51687699
Extracellular adenosine initiates rapid arteriolar vasodilation induced by a single skeletal muscle contraction in hamster cremaster muscle.Q51755331
Development of microvascular rarefaction in the spontaneously hypertensive rat.Q51859998
Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity.Q54013893
Red blood cell regulation of microvascular tone through adenosine triphosphate.Q54056545
Carotid baroreflex control of leg vasculature in exercising and non-exercising skeletal muscle in humans.Q54228741
Reduced Leg Blood Flow during Submaximal Exercise in Type 2 DiabetesQ60616972
Muscle blood flow in diabetes mellitus. Evidence of abnormality after exerciseQ68032825
Type 2 diabetes mellitus and exercise impairmentQ36673620
Mitochondrial oxidative function and type 2 diabetesQ36703611
Left ventricular function in diabetes mellitus. II: Relation between clinical features and left ventricular functionQ36778779
Diabetic cardiomyopathy revisitedQ36860318
Exercise hyperaemia: is anything obligatory but the hyperaemia?Q36886654
Red not dead: signaling in and from erythrocytesQ36981005
A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic reviewQ36987077
Mechanisms of rapid vasodilation after a brief contraction in human skeletal muscleQ37054924
Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitusQ37780592
Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysisQ38122327
Arterial function in cardio-metabolic diseases: from the microcirculation to the large conduitsQ38249072
Clinical depression versus distress among patients with type 2 diabetes: not just a question of semanticsQ38399002
The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise InterventionsQ38815425
Insidious incrementalism: The silent failure of the microcirculation with increasing peripheral vascular disease riskQ38942823
Fatiguability and Fibre Composition of Human Skeletal MuscleQ39794330
Factors affecting the rate and energetics of mitochondrial oxidative phosphorylationQ40727993
Perceived exertion. Antecedents and applicationsQ40890612
A delivery-independent blood flow effect on skeletal muscle fatigueQ41474223
Nitrite directly vasodilates hypoxic vasculature via nitric oxide-dependent and -independent pathwaysQ42589045
Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetesQ42804939
Noninvasive estimation of microvascular O2 provision during exercise on-transients in healthy young males.Q43473630
GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?Q43618919
Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP releaseQ43730250
Effect of altered arterial O2 tensions on muscle metabolism in dog skeletal muscle during fatiguing workQ43814911
Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitusQ43857108
Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle?Q44013303
Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjectsQ44081019
Dynamics of microvascular oxygen pressure during rest-contraction transition in skeletal muscle of diabetic ratsQ44103904
Abnormal metabolic fate of nitric oxide in Type I diabetes mellitusQ44219619
Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilationQ44333635
Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetesQ44480693
Activation of ATP/UTP-selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscleQ44585114
Heterotrimeric G protein Giis involved in a signal transduction pathway for ATP release from erythrocytesQ44654252
Exercise capacity and body composition as predictors of mortality among men with diabetesQ44705135
Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobinQ44764243
Cardiac output is not related to the slowed O2 uptake kinetics in type 2 diabetes.Q44948565
Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscleQ44991344
Impaired Tissue Oxygenation in Metabolic Syndrome Requires Increased Microvascular Perfusion Heterogeneity.Q45052284
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetesQ45199109
Compliance with physical activity recommendations in US adults with diabetesQ45243180
Determinants of exercise capacity in patients with type 2 diabetesQ46570708
Normalization of diastolic dysfunction in type 2 diabetics after exercise trainingQ46911725
A conceptual framework for predicting and addressing the consequences of disease-related microvascular dysfunction.Q47982355
Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetesQ48162668
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)1117-1139
P577publication date2018-02-08
P1433published inJournal of Applied PhysiologyQ1091719
P1476titleExercise intolerance in Type 2 diabetes: is there a cardiovascular contribution?
P478volume124

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cites work (P2860)
Q90701757Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial
Q89963511Increased Cardiovascular Response to a 6-Minute Walk Test in People With Type 2 Diabetes

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