Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber

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Acting on identity: Myoblast fusion and the formation of the syncytial muscle fiber is …
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scholarly articleQ13442814

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P356DOI10.1016/J.SEMCDB.2017.10.033
P932PMC publication ID5910025
P698PubMed publication ID29101004

P2093author name stringSu Deng
Mary Baylies
Mafalda Azevedo
P2860cites workSCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusionQ40887859
Live imaging of Drosophila myoblast fusionQ40963779
Satellite cell proliferation and the expression of myogenin and desmin in regenerating skeletal muscle: evidence for two different populations of satellite cells.Q40992064
Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusionQ22254011
Structure and control of the actin regulatory WAVE complexQ24308919
G-protein coupled receptor BAI3 promotes myoblast fusion in vertebratesQ24338272
The cell adhesion molecule M-cadherin is not essential for muscle development and regenerationQ24537537
D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesisQ24562839
Viral and developmental cell fusion mechanisms: conservation and divergenceQ24631787
The CDM superfamily protein MBC directs myoblast fusion through a mechanism that requires phosphatidylinositol 3,4,5-triphosphate binding but is independent of direct interaction with DCrkQ24672486
Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organizationQ24676790
A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in DrosophilaQ24678756
Specification of the somatic musculature in DrosophilaQ26849725
Morphogenesis of the somatic musculature in Drosophila melanogasterQ26853033
Tethering membrane fusion: common and different players in myoblasts and at the synapseQ27023254
Identification of a Drosophila homologue to vertebrate Crk by interaction with MBCQ27219697
Shaping leg muscles in Drosophila: role of ladybird, a conserved regulator of appendicular myogenesisQ27303134
Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles.Q27310000
The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 RegulationQ27310704
Live imaging provides new insights on dynamic F-actin filopodia and differential endocytosis during myoblast fusion in DrosophilaQ27322568
Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regenerationQ27325652
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and NckQ28218186
A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusionQ28239021
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteinsQ28272422
Developmental defects in mouse embryos lacking N-cadherinQ28302581
Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissueQ28307252
Normal myoblast fusion requires myoferlinQ41006330
Physiological properties of the dorsal longitudinal flight muscle and the tergal depressor of the trochanter muscle of Drosophila melanogasterQ41191483
Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Q41285280
The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesisQ41951128
Development of the indirect flight muscles of DrosophilaQ42171252
The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusionQ42563405
Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic musclesQ46007051
mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivoQ46055034
Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insectsQ47070040
rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion.Q47070577
A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesisQ47070890
The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signalingQ47070961
The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in DrosophilaQ47071045
Antisocial, an intracellular adaptor protein, is required for myoblast fusion in DrosophilaQ47071234
Drosophila dumbfounded: a myoblast attractant essential for fusionQ47071602
Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cuesQ47071764
Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant DumbfoundedQ47072203
Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryoQ47072261
Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia.Q47072337
Control of Myoblast Fusion by a Guanine Nucleotide Exchange Factor, Loner, and Its Effector ARF6Q47072371
rst and its paralogue kirre act redundantly during embryonic muscle development in DrosophilaQ47072376
The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like proteinQ47072423
A conserved molecular pathway mediates myoblast fusion in insects and vertebratesQ47073444
Myomaker mediates fusion of fast myocytes in zebrafish embryosQ47073524
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb.Q51099866
Rac function and regulation during Drosophila development.Q52122073
Myoblast diversification and ectodermal signaling in Drosophila.Q52126664
Multiple roles for notch in Drosophila myogenesis.Q52184657
Segregation of myogenic lineages in Drosophila requires numb.Q52191445
Segmentation and specification of the Drosophila mesoderm.Q52198053
dpp induces mesodermal gene expression in Drosophila.Q52212324
Myogenesis: a view from Drosophila.Q52564161
Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts.Q52744666
Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesisQ57223535
Myonuclear birthdates distinguish the origins of primary and secondary myotubes in embryonic mammalian skeletal musclesQ69573479
Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts. Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myotQ73066721
Beta1 integrins regulate myoblast fusion and sarcomere assemblyQ73370668
ladybird determines cell fate decisions during diversification of Drosophila somatic musclesQ77145536
IL-4 acts as a myoblast recruitment factor during mammalian muscle growthQ28505736
A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusionQ28507874
MyoD or Myf-5 is required for the formation of skeletal muscleQ28510042
CKIP-1 regulates mammalian and zebrafish myoblast fusionQ28511208
Myomaker is essential for muscle regenerationQ28585754
Myomaker is a membrane activator of myoblast fusion and muscle formationQ28586981
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin geneQ28592173
Pax7 is required for the specification of myogenic satellite cellsQ28593927
Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblastsQ30010006
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusionQ30416374
RhoA GTPase regulates M-cadherin activity and myoblast fusionQ30476701
3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusionQ30488786
Nap1-mediated actin remodeling is essential for mammalian myoblast fusionQ30489945
Dependence of myoblast fusion on a cortical actin wall and nonmuscle myosin IIA.Q30493190
Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in DrosophilaQ30498965
PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion siteQ30578901
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle developmentQ33112259
Control of muscle formation by the fusogenic micropeptide myomixer.Q33112265
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivoQ33372285
The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and LonerQ33534699
A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesisQ33549660
Muscle pattern diversification in Drosophila: the story of imaginal myogenesisQ33685706
Myoblast fusion: when it takes more to make one.Q33787549
A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.Q33891096
Preferential adhesion maintains separation of ommatidia in the Drosophila eye.Q34065561
Jamb and jamc are essential for vertebrate myocyte fusionQ34105131
Jamb and jamc muscle in on myoblast fusionQ34105135
The type I membrane protein EFF-1 is essential for developmental cell fusionQ34117126
Identification of a new stem cell population that generates Drosophila flight musclesQ34228155
Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesisQ34295219
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant miceQ34350930
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion.Q34368627
Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identityQ34391714
A Pax3/Pax7-dependent population of skeletal muscle progenitor cellsQ34412889
Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomesQ34718387
Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctionsQ35005808
Mechanical tension drives cell membrane fusionQ35171103
Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesisQ35189774
Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo.Q35229802
M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusionQ35757362
The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion.Q36014662
The actin regulator N-WASp is required for muscle-cell fusion in miceQ36094269
Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complexQ36254677
Fusion competence of myoblasts rendered genetically null for N-cadherin in cultureQ36268144
Membrane fusion in muscle development and repairQ36372961
The chicken embryo as an efficient model to test the function of muscle fusion genes in amniotesQ36375580
Dynamics of transcriptional (re)-programming of syncytial nuclei in developing muscles.Q36397186
Analysis of the cell adhesion molecule sticks-and-stones reveals multiple redundant functional domains, protein-interaction motifs and phosphorylated tyrosines that direct myoblast fusion in Drosophila melanogasterQ36515837
Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogasterQ37035007
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouseQ37193382
The immunoglobulin superfamily member Hbs functions redundantly with Sns in interactions between founder and fusion-competent myoblastsQ37201425
The genetics of vertebrate myogenesisQ37219522
Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organizationQ37230539
Diaphanous regulates SCAR complex localization during Drosophila myoblast fusionQ37284192
Recent advances in the biology of WASP and WIP.Q37329112
MOR23 promotes muscle regeneration and regulates cell adhesion and migrationQ37428310
Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturationQ37429777
FuRMAS: triggering myoblast fusion in DrosophilaQ37471641
Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in DrosophilaQ38358740
Myoblast fusion: Experimental systems and cellular mechanismsQ38899104
The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblastsQ39346606
The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion.Q40087925
A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusionQ40147673
WIP/WASp-based actin-polymerization machinery is essential for myoblast fusion in DrosophilaQ40147679
WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in DrosophilaQ40204093
Myomaker, Regulated by MYOD, MYOG and miR-140-3p, Promotes Chicken Myoblast FusionQ40352908
Inflammatory cell response to acute muscle injury.Q40415998
Identification of singles bar as a direct transcriptional target of Drosophila Myocyte enhancer factor-2 and a regulator of adult myoblast fusionQ40425109
Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion.Q40443633
Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesodermQ40446468
Molecular and cell biology of skeletal muscle regenerationQ40716611
P921main subjectmyoblastQ1956694
P304page(s)45-55
P577publication date2017-10-31
P1433published inSeminars in Cell & Developmental BiologyQ14330411
P1476titleActing on identity: Myoblast fusion and the formation of the syncytial muscle fiber
P478volume72

Reverse relations

cites work (P2860)
Q64230662A Large Scale Systemic RNAi Screen in the Red Flour Beetle Identifies Novel Genes Involved in Insect Muscle Development
Q54982478Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy.
Q89565304Blastulation of a zygote to a hatched blastocyst without any clear cell division: an observational finding in a time-lapse system after in vitro fertilization
Q91900409Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme
Q100532924Cytoplasmic sharing through apical membrane remodeling
Q50420077Drosophila globin1 is required for maintenance of the integrity of F-actin based cytoskeleton during development
Q90980349Expression of Hbs, Kirre, and Rst during Drosophila ovarian development
Q89489166Getting into Position: Nuclear Movement in Muscle Cells
Q89944311Identification of the Differentially Expressed Genes of Muscle Growth and Intramuscular Fat Metabolism in the Development Stage of Yellow Broilers
Q97685270Intrinsic control of muscle attachment sites matching
Q57471964Myogenin promotes myocyte fusion to balance fibre number and size
Q64096743Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle
Q92580618Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers
Q64230628RNAi Screen in Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects
Q90028654Reverse engineering forces responsible for dynamic clustering and spreading of multiple nuclei in developing muscle cells
Q92090019Selective Targeting of Myoblast Fusogenic Signaling and Differentiation-Arrest Antagonizes Rhabdomyosarcoma Cells
Q59132981Specialized Positioning of Myonuclei Near Cell-Cell Junctions
Q64947750Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion.
Q91985737The Crk adapter protein is essential for Drosophila embryogenesis, where it regulates multiple actin-dependent morphogenic events
Q59806119The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
Q90131696The fusogenic synapse at a glance

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