Epigenetics and Developmental Origins of Diabetes: Correlation or Causation?

scientific article

Epigenetics and Developmental Origins of Diabetes: Correlation or Causation? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00424.2017
P932PMC publication ID6334998
P698PubMed publication ID29406781

P50authorAmita BansalQ85644716
P2093author name stringRebecca A Simmons
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Maternal diabetes causes abnormal dynamic changes of endoplasmic reticulum during mouse oocyte maturation and early embryo development.Q30539215
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An upstream repressor element plays a role in Igf2 imprintingQ30684867
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetesQ33636415
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Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility lociQ34518460
Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspringQ34734668
Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAsQ34738450
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.Q34750222
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.Q34777247
Epigenetic gene promoter methylation at birth is associated with child's later adiposityQ35046716
Fetal and infant growth and impaired glucose tolerance at age 64.Q35181794
Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protectionQ35206511
Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse.Q35603382
Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.Q35704499
Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderlyQ36047172
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Urinary phthalate metabolite concentrations and diabetes among women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008.Q36229185
Perinatal programming and functional teratogenesis: impact on body weight regulation and obesityQ36310153
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A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primatesQ36430795
Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspringQ36646369
Metabolic programming of MEST DNA methylation by intrauterine exposure to gestational diabetes mellitus.Q36720609
Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgeryQ37010709
Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cellQ37237997
Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placentaQ37274079
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participantsQ37368135
Responses of the embryonic epigenome to maternal diabetesQ37438598
Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseasesQ37445227
Animal models of in utero exposure to a high fat diet: a reviewQ37492276
Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in miceQ37497530
DNA methylation in oocytes and liver of female mice and their offspring: effects of high-fat-diet-induced obesityQ37559528
Phthalate exposure associated with self-reported diabetes among Mexican womenQ37589499
Imprinting and epigenetic changes in the early embryoQ37598628
Cell signaling and transcriptional regulation via histone phosphorylationQ37861959
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cellsQ37965513
Do phthalates act as obesogens in humans? A systematic review of the epidemiological literatureQ38177864
DNA methylation profiles in placenta and its association with gestational diabetes mellitusQ38299107
Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR ratsQ38462433
The potential of DNA modifications as biomarkers and therapeutic targets in oncologyQ38591064
Diagnostic and prognostic epigenetic biomarkers in cancerQ38610743
Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspringQ39045506
Endocrine-disrupting chemicals and the regulation of energy balanceQ39317709
Weight in infancy and death from ischaemic heart diseaseQ41277168
Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling.Q41683791
Minireview: Epigenomic Plasticity and Vulnerability to EDC ExposuresQ42395101
Gestational exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pancreatic β-cell function in F1 rat offspringQ42703997
F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.Q42705778
Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthoodQ42710778
Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation.Q42952018
Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 modulate beta-cell chromatin structureQ43136823
The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.Q43248455
Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.Q43748928
Increased hepatic peroxisome proliferator-activated receptor-gamma coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistanceQ44033418
Congenital Susceptibility to NIDDM: Role of Intrauterine EnvironmentQ44047223
Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.Q44328972
Migration of phthalates from plastic products to model solutions.Q44573666
Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver.Q45115117
GLUT4 expression and subcellular localization in the intrauterine growth-restricted adult rat female offspringQ45206215
Low birthweight is associated with specific changes in muscle insulin-signalling protein expressionQ45281578
Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspringQ45323719
Phthalate levels and low birth weight: a nested case-control study of Chinese newborns.Q45952779
Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspringQ46522809
Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring.Q47574498
Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes PathogenesisQ48095510
Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity.Q50436603
Phthalate exposure in utero causes epigenetic changes and impairs insulin signalling.Q50633963
Paternal BPA exposure in early life alters Igf2 epigenetic status in sperm and induces pancreatic impairment in rat offspring.Q50995108
Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism.Q51038774
Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat.Q51372050
Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.Q51435787
Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle.Q51538592
Cohort Profile: The Dutch Hunger Winter Families StudyQ57586723
Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetusesQ73924462
P433issue1
P921main subjectepigeneticsQ26939
P304page(s)E15-E28
P577publication date2018-02-06
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleEpigenetics and developmental origins of diabetes: correlation or causation?
P478volume315

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cites work (P2860)
Q57786921Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?
Q64121823Epigenome-wide association study in peripheral white blood cells involving insulin resistance
Q90177464In utero Bisphenol A Exposure Is Linked with Sex Specific Changes in the Transcriptome and Methylome of Human Amniocytes
Q89964377Maternal Inulin Supplementation Alters Hepatic DNA Methylation Profile and Improves Glucose Metabolism in Offspring Mice
Q92982386Metabolic programming in early life in humans
Q64260349Mother or Father: Who Is in the Front Line? Mechanisms Underlying the Non-Genomic Transmission of Obesity/Diabetes via the Maternal or the Paternal Line
Q64088446Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes

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