Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice.

scientific article published on 21 February 2018

Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0193012
P932PMC publication ID5821371
P698PubMed publication ID29466436

P50authorJonathan E KurzQ60710651
Daniel W FisherQ87838928
P2093author name stringDane M Chetkovich
Neha Agarwal
Phillip Luu
P2860cites workRegulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides.Q51144787
Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.Q52148370
Molecular and functional analysis of hyperpolarisation-activated nucleotide-gated (HCN) channels in the enteric nervous system.Q54693495
HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic PainQ58791990
A hyperpolarization-activated, cyclic nucleotide-gated, (Ih-like) cationic current and HCN gene expression in renal inner medullary collecting duct cellsQ80502728
A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouseQ83954259
Role of calcium in activation of hyperpolarization-activated cyclic nucleotide-gated channels caused by cholecystokinin octapeptide in interstitial cells of cajalQ84004984
Gastrointestinal dysfunction in Parkinson's DiseaseQ84489324
The distribution of HCN2-positive cells in the gastrointestinal tract of miceQ84579941
Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neuronsQ37608503
Altered GI motility in critically Ill patients: current understanding of pathophysiology, clinical impact, and diagnostic approachQ37686923
Determinants of GH resistance in malnutritionQ37715013
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidenceQ38616098
HCN2 ion channels: basic science opens up possibilities for therapeutic intervention in neuropathic pain.Q38821912
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Q39696685
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissuesQ40067390
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cellsQ40760593
Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cellsQ43265007
Postnatal growth in the intestineQ45828710
Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.Q48251409
The effect of dietary protein on thyrotropin-releasing hormone and thyrotropin gene expressionQ48319095
Characterization of myenteric sensory neurons in the mouse small intestineQ48450853
Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesisQ21128678
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2Q28507182
Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid bodyQ28576246
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulationQ28576494
A mouse model demonstrates a multigenic origin of congenital hypothyroidismQ28592837
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in miceQ30429700
Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsyQ30485454
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2Q30486037
Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsyQ30691989
Association between hyperpolarization-activated channel in interstitial cells of Cajal and gastrointestinal dysmotility induced by malignant ascitesQ33597650
The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of CajalQ33722384
Interstitial cells of Cajal, the Maestro in health and diseaseQ33978116
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.Q34680409
HCN channels in behavior and neurological disease: too hyper or not active enough?Q34777401
The fast and slow ups and downs of HCN channel regulation.Q35147010
Gut chemosensing mechanismsQ35183915
Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's diseaseQ35594271
The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cellsQ35640687
Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclaseQ35778348
Twists and turns in the development and maintenance of the mammalian small intestine epitheliumQ36101938
Nutrition aspects of gastroparesis and therapies for drug-refractory patientsQ36378737
From the bench to the 'crib'-side: implications of scientific advances to paediatric neurogastroenterology and motilityQ36428527
Mechanisms of disease: the pathological basis of gastroparesis--a review of experimental and clinical studiesQ36836634
The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron.Q37118173
Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.Q37315111
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)e0193012
P577publication date2018-02-21
P1433published inPLOS OneQ564954
P1476titleLoss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice
P478volume13

Reverse relations

Q64990227Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases.cites workP2860

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