SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1225957)

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) is …
instance of (P31):
biological processQ2996394

External links are
P2888exact matchhttps://identifiers.org/reactome:R-HSA-1225957
P3937Reactome IDR-HSA-1225957

P2860cites workEGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycinsQ40396742
P703found in taxonHomo sapiensQ15978631
P527has part(s)GTP(4−)Q27117191
GDP(3−)Q27125487
p21 RAS:GDP [plasma membrane]Q50254136
p21 RAS:GTP [plasma membrane]Q50254141
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]Q50255480
P361part ofConstitutive Signaling by Ligand-Responsive EGFR Cancer VariantsQ45314351

Reverse relations

part of (P361)
Q50255480Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
Q50254136p21 RAS:GDP [plasma membrane]
Q50254141p21 RAS:GTP [plasma membrane]

Q45314351Constitutive Signaling by Ligand-Responsive EGFR Cancer Variantshas part(s)P527

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