Vitamin C Fosters the In Vivo Differentiation of Peripheral CD4+ Foxp3- T Cells into CD4+ Foxp3+ Regulatory T Cells but Impairs Their Ability to Prolong Skin Allograft Survival.

scientific article published on 9 February 2018

Vitamin C Fosters the In Vivo Differentiation of Peripheral CD4+ Foxp3- T Cells into CD4+ Foxp3+ Regulatory T Cells but Impairs Their Ability to Prolong Skin Allograft Survival. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2018.00112
P932PMC publication ID5811461
P698PubMed publication ID29479348

P50authorKarina Pino-LagosQ60326664
P2093author name stringMauricio Campos-Mora
Karina Oyarce
Tania Gajardo-Carrasco
P2860cites workMetabolic regulation of regulatory T cell development and functionQ26852681
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
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Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature.Q46210096
Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cellsQ46535411
Fluorimetric determination of ascorbic acid in vitamin C tablets using methylene blueQ46736062
High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice.Q50756977
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Q50968365
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
Dynamics of peripheral tolerance and immune regulation mediated by Treg.Q52595030
Vitamin C-treated murine bone marrow-derived dendritic cells preferentially drive naïve T cells into Th1 cells by increased IL-12 secretionsQ54633096
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsQ58234949
Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejectionQ85932260
Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent MannerQ87186886
Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantationQ34454926
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulationQ34580976
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.Q34655006
A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunityQ35208406
Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and ButyrateQ35926395
Tregs and transplantation toleranceQ35951541
Control of Foxp3 stability through modulation of TET activityQ36745015
Vitamin C is taken up by human T cells via sodium-dependent vitamin C transporter 2 (SVCT2) and exerts inhibitory effects on the activation of these cells in vitroQ37053078
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Macrophage differentiation increases expression of the ascorbate transporter (SVCT2)Q37067007
A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cellsQ37154121
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivoQ37312884
Vitamin C promotes maturation of T-cellsQ37406667
A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acidQ37490205
Vitamin C enhances the expression of IL17 in a Jmjd2-dependent mannerQ37656525
Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer TherapyQ37717910
Retinoic acid: A key player in immunityQ37783965
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An update on vitamin D and human immunityQ37945341
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Regulatory T-cell immunotherapy for allogeneic hematopoietic stem-cell transplantationQ38095964
Modulation of T cell and innate immune responses by retinoic AcidQ38198610
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Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activationQ38514707
Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative ColitisQ38657587
Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.Q38662974
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Clinical-grade regulatory T cells: Comparative analysis of large-scale expansion conditionsQ39331928
Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance.Q40137278
Levels of Foxp3 in regulatory T cells reflect their functional status in transplantationQ42042533
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cellsQ42793227
A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation.Q42830566
High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged miceQ43260877
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritisQ44688981
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectvitamin CQ199678
P304page(s)112
P577publication date2018-02-09
P1433published inFrontiers in ImmunologyQ27723748
P1476titleVitamin C Fosters the In Vivo Differentiation of Peripheral CD4+ Foxp3- T Cells into CD4+ Foxp3+ Regulatory T Cells but Impairs Their Ability to Prolong Skin Allograft Survival
P478volume9

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cites work (P2860)
Q57067461Autophagy is positively associated with the accumulation of myeloid‑derived suppressor cells in 4‑nitroquinoline‑1‑oxide‑induced oral cancer
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Q90176770The Impact of Dietary Components on Regulatory T Cells and Disease
Q92124664Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse

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