Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection

scientific article published on 27 February 2018

Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1101148953
P356DOI10.1038/S41598-018-22139-6
P932PMC publication ID5829072
P698PubMed publication ID29487367

P50authorOlivier TerrierQ56240973
Manuel Rosa-CalatravaQ56432987
Jean-Christophe BourdonQ56809446
Andrés PizzornoQ56812313
Bruno LinaQ61117468
Aurélien TraversierQ84076450
Julia DuboisQ86983008
P2093author name stringThomas Julien
Gaëlle Cartet
Daniela Machado
P2860cites workInfluenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IQ24312113
Human host factors required for influenza virus replicationQ24629972
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
p53-independent roles of MDM2 in NF-κB signaling: implications for cancer therapy, wound healing, and autoimmune diseasesQ28611425
Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.Q30159525
Influenza.Q30235246
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.Q30384547
The first influenza pandemic of the new millenniumQ30401658
The pathogenesis of influenza virus infections: the contributions of virus and host factorsQ30405941
Influenza virus infection increases p53 activity: role of p53 in cell death and viral replicationQ33883836
Hantaan virus nucleocapsid protein stimulates MDM2-dependent p53 degradationQ33887364
Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathwayQ33926096
Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replicationQ34047120
p53 Research: the past thirty years and the next thirty years.Q34313764
MDM2 is a target of simian virus 40 in cellular transformation and during lytic infectionQ35895678
Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53.Q36003013
Influenza A viruses control expression of proviral human p53 isoforms p53β and Delta133p53α.Q36172140
Influenza viruses and the NF-kappaB signaling pathway - towards a novel concept of antiviral therapyQ37247082
A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathwayQ37416250
Emerging roles of p53 and other tumour-suppressor genes in immune regulationQ37666015
Uncovering the global host cell requirements for influenza virus replication via RNAi screening.Q37833240
Old friends in new guise: repositioning of known drugs with structural bioinformaticsQ37858324
Interference with p53 functions in human viral infections, a target for novel antiviral strategies?Q37897197
Scission of the p53-MDM2 Loop by Ribosomal ProteinsQ38059701
Drugging the p53 pathway: understanding the route to clinical efficacyQ38191796
Unravelling mechanisms of p53-mediated tumour suppressionQ38205099
p53-independent effects of Mdm2.Q38247164
The NS1 Protein from Influenza Virus Stimulates Translation Initiation by Enhancing Ribosome Recruitment to mRNAs.Q38824998
TRIM25 has a dual function in the p53/Mdm2 circuitQ38904816
Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner.Q39109027
The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses.Q39318453
Importance of viral genomic composition in modulating glycoprotein content on the surface of influenza virus particles.Q39563269
In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?Q39680790
Caspase 3 activation is essential for efficient influenza virus propagationQ39764205
Influenza A virus induces p53 accumulation in a biphasic patternQ39874897
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.Q40264689
The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanismQ40508316
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.Q40783221
Concepts in MDM2 Signaling: Allosteric Regulation and Feedback LoopsQ41287167
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.Q41511192
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signalingQ45404540
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)3746
P577publication date2018-02-27
P1433published inScientific ReportsQ2261792
P1476titleInfluenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection
P478volume8

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cites work (P2860)
Q52315669Cell culture-derived flu vaccine: Present and future.
Q90697417Innate Immune Evasion by Human Respiratory RNA Viruses

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