α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

scientific article published in March 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2018.02.032
P932PMC publication ID6368357
P698PubMed publication ID29514095

P50authorDiane C. SaundersQ87032967
Matthias G von HerrathQ88828481
P2093author name stringMark Atkinson
Roland Stein
Dale L Greiner
Leonard D Shultz
Louis H Philipson
Martha Campbell-Thompson
Alvin C Powers
Rita Bottino
David M Harlan
Gregory Poffenberger
Nripesh Prasad
Shawn E Levy
Chunhua Dai
Marcela Brissova
Jill Lindner
Fong Cheng Pan
Radhika Aramandla
May Sanyoura
Shristi Shrestha
Rachana Haliyur
David M Blodgett
P2860cites workRfx6 directs islet formation and insulin production in mice and humansQ24298978
RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cellsQ24309248
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cellsQ27319807
In vivo reprogramming of adult pancreatic exocrine cells to beta-cellsQ28292190
Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regenerationQ33577410
Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosisQ33646636
Nkx6.1 is essential for maintaining the functional state of pancreatic beta cellsQ33756959
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell lossQ33881638
Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.Q34237680
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.Q34403048
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreasQ34744604
Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles.Q35273899
Rfx6 maintains the functional identity of adult pancreatic β cells.Q35973399
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell SubsetsQ35973858
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.Q36867289
Inactivation of specific β cell transcription factors in type 2 diabetesQ37052883
Human islets contain four distinct subtypes of β cellsQ37089019
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.Q37348520
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cellsQ37374229
A Single-Cell Transcriptome Atlas of the Human PancreasQ37389071
Pdx1 maintains β cell identity and function by repressing an α cell programQ37632375
Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1.Q39896293
Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro: Results From the DiViD StudyQ42166138
Recovery from diabetes in mice by beta cell regenerationQ42408079
Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic NervesQ42409235
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signalingQ44899742
Regulated beta-cell regeneration in the adult mouse pancreas.Q46579133
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.Q49921967
Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.Q50455092
Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.Q54340182
Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine SecretionQ70241309
Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreataQ73810376
Function of pancreatic islets isolated from a type 1 diabetic patientQ73840644
Improved molecular diagnosis of patients with neonatal diabetes using a combined next-generation sequencing and MS-MLPA approachQ87324995
P433issue10
P921main subjecttype-1 diabetesQ124407
P304page(s)2667-2676
P577publication date2018-03-01
P1433published inCell ReportsQ5058165
P1476titleα Cell Function and Gene Expression Are Compromised in Type 1 Diabetes
P478volume22