Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation.

scientific article published on 18 May 2017

Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-17-0171
P932PMC publication ID5587368
P698PubMed publication ID28522584

P50authorAdriana ZingoneQ23498559
Ola LandgrenQ66432182
Wendy DuboisQ67472636
P2093author name stringJing Huang
W Michael Kuehl
Joy Gary
Ke Zhang
Maxwell P Lee
Aleksandra M Michalowski
Beverly A Mock
Elena Leon
John K Simmons
Shuling Zhang
Jin-Qiu Chen
Peter Ordentlich
Jyoti Patel
Nicholas Watson
Daniel Connors
Snehal Gaikwad
Benjamin J Gamache
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Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.Q36204839
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PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy.Q39120295
AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expressionQ40623520
Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2Q42152675
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A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1.Q53246749
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P433issue9
P304page(s)2008-2021
P577publication date2017-05-18
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleCooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation.
P478volume16

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cites work (P2860)
Q50532101A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment.
Q91494245CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression
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Q64928553HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action.
Q64061318Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy
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Q48530866mTOR Cross-Talk in Cancer and Potential for Combination Therapy.