Ku80 as a novel receptor for thymosin beta4 that mediates its intracellular activity different from G-actin sequestering

scientific article published on 4 November 2007

Ku80 as a novel receptor for thymosin beta4 that mediates its intracellular activity different from G-actin sequestering is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M707539200
P698PubMed publication ID17984099

P50authorCzesław CierniewskiQ16334746
Joanna BoncelaQ59694856
Radoslaw BednarekQ47333080
P2093author name stringElzbieta Wyroba
Katarzyna Smolarczyk
Aleksandra Cierniewska-Cieslak
P2860cites workBinding of PAI-1 to endothelial cells stimulated by thymosin beta4 and modulation of their fibrinolytic potentialQ24293732
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndromeQ24558767
HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometriumQ24564690
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repairQ27634006
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide GelsQ27860531
Genomic analysis of metastasis reveals an essential role for RhoCQ28144278
Interferon-alpha signaling promotes nucleus-to-cytoplasmic redistribution of p95Vav, and formation of a multisubunit complex involving Vav, Ku80, and Tyk2Q28144695
Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domainQ28204714
Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptorQ28289980
Differential expression of thymosin genes in human tumors and in the developing human kidneyQ28290524
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairQ28295270
MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancerQ29620125
Eukaryotic gene transcription with purified componentsQ29620213
Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoidsQ33882219
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Q34181022
Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic systemQ34248639
Antimicrobial peptides from human plateletsQ34258124
Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related researchQ34503665
Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes, GRP78 and GRP94Q35786222
Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cellsQ35788792
The double life of the Ku protein: facing the DNA breaks and the extracellular environment.Q36058274
Thymosin beta4: actin-sequestering protein moonlights to repair injured tissuesQ36228847
c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylaseQ36316558
Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomasQ36785156
Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.Q36899057
The membrane form of the DNA repair protein Ku interacts at the cell surface with metalloproteinase 9.Q38336225
Requirement for Ku80 in growth and immunoglobulin V(D)J recombinationQ38354221
Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinomaQ40538880
Role of thymosin beta4 in tumor metastasis and angiogenesisQ40615494
Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitroQ41665140
Co-ordinate regulation of the cytoskeleton in 3T3 cells overexpressing thymosin-beta4.Q42805180
Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis modelQ43814085
Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injuryQ43957139
Induction of PAI-1 expression by tumor necrosis factor alpha in endothelial cells is mediated by its responsive element located in the 4G/5G siteQ46798284
Thymosin beta 4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expressionQ47410864
Thymosin beta4 enhances endothelial cell differentiation and angiogenesisQ47596525
Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cellsQ47895581
The actin binding site on thymosin β4promotes angiogenesisQ52100134
Thymosin beta4 accelerates wound healing.Q52174788
Sequence-specific DNA binding by Ku autoantigen and its effects on transcriptionQ59079114
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1534-1544
P577publication date2007-11-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleKu80 as a novel receptor for thymosin beta4 that mediates its intracellular activity different from G-actin sequestering
P478volume283

Reverse relations

cites work (P2860)
Q37221061A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing.
Q42260483A thymosin beta15-like peptide promotes intersegmental myotome extension in the chicken embryo
Q34944464Cell and molecular biology of nuclear actin.
Q44837629Expression profiling of functional genes in prenatal skeletal muscle tissue in Duroc and Pietrain pigs
Q38694367Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Q30317274MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2.
Q93178356N-acetyl-seryl-aspartyl-lysyl-proline treatment protects heart against excessive myocardial injury and heart failure in mice
Q41832205Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats
Q85317865Plasminogen activator inhibitor-1 (PAI-1) expression in relation to hypoxia and oncoproteins in clinical cervical tumors
Q37465071The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family
Q39016676Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1.
Q28910436Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
Q36855028Thymosin β 4 mediates oligodendrocyte differentiation by upregulating p38 MAPK.
Q53215125Thymosin β4 induces proliferation, invasion, and epithelial-to-mesenchymal transition of oral squamous cell carcinoma.
Q43930449Thymosin β4 is rapidly internalized by cells and does not induce intracellular Ca2+ elevation.
Q47678660Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation
Q43290413Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis
Q42400368Treatment of traumatic brain injury with thymosin β₄ in rats

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